pyrB
mL0532
Probable aspartate carbamoyltransferase PyrB (Aspartate transcarbamylase) (ATCase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 645582 – 646547
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0532_pyrB_dna
TGATGCGCAGACATCTGCTGAACGCCGGTGATTTGAGCCGCGACGATGCCATCGCCATCTTCGACGATGCCGACCGGTTCGCGCATGCTCTGGTGGGTCGCGAGATCAAGAAGCTGCCGACGCTACGAGGTCGCACGGTAATCACGATGTTCTACGAAAATTCGACTCGCACCCGCGTGTCGTTCGAGGTGGCCGGCAAGTGGATGAGCGCCAATGTGATCAACGTCAGCCCGGCTGGATCGTCGGTGGGTAAGGGCGAATCGTTGCGTGACACCGCGCTGACACTGCGTGCGGCCGGTGCTGACGCGTTGATTATCCGGCACCCGGCTTCCGGTGCTGCCCATCTGCTTGCCGATTGGACTGCTGCTGAGACCGGCGAGGATGGTCCGGCGGTGATCAACGCCGGCGACGGCACTCATGAGCACCCGACCCAGGCGCTGCTGGACGCGCTCACCATCCGTCAGCGGCTCGGTAGCATTGAAGGCCGGCGCATCTTGATCGTCGGCGACATCTTGCACAGCCGGGTTGCGCGGTCCAACGTCGTGCTGCTAGACACCCTGGGTGCTGAGGTGGTGCTGGTGGCGCCGCGGACTTTGTTGCCGATTGGGGTTGACGGCTGGCCAGCCACCGTCTCATGCGACTTTGACGCTGAACTGCCTGCCGCCGATGCGGTGCTGATGCTGCGAGTACAGGCCGAACGGATGAATGGCGGGTTTTTCCCGTCGGTACGCGAGTATTCTTGTCTCTACGGGCTAACCGAGCGGCGCCAGGCACTGTTGCCCGGCCATGCAGTGGTGCTGCACCCAGGGCCGATGCTACGTGGCATGGAGATCGCCTCTTCTGTTGCTGACTCGTCGCAATCAGCTGTTTTGCAACAGGTTTCCAACGGTGTGCATGTGCGGATGGCAGTGCTTTTCCATGTTCTGGTTGGGACCCAGTCGGCCGAAGAAGAGGGTGCGGCATGAG

Protein Sequence 

>ML0532_PyrB_protein
CADIC_TPVI_AATMPSPSSTMPTGSRMLWWVARSRSCRRYEVAR_SRCSTKIRLAPACRSRWPASG_APM_STSARLDRRWVRANRCVTPR_HCVRPVLTR_LSGTRLPVLPICLPIGLLLRPARMVRR_STPATALMSTRPRRCWTRSPSVSGSVALKAGAS_SSATSCTAGLRGPTSCC_TPWVLRWCWWRRGLCCRLGLTAGQPPSHATLTLNCLPPMRC_CCEYRPNG_MAGFSRRYASILVSTG_PSGARHCCPAMQWCCTQGRCYVAWRSPLLLLTRRNQLFCNRFPTVCMCGWQCFSMFWLGPSRPKKRVRHE

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PyrB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

33 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PyrB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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