pyrC
mL0533
Probable dihydroorotase PyrC (DHOase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 646544 – 647836
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0533_pyrC_dna
TGAGCGTGTTACTTCGTGGTGTCCGCTTGTATGGCGAGGGTGAACAAGTCGATGTACTGGTTGAGGGCGAGCAGATCGCCAACATTGGTGCTGGTATTGATATTCCCGACACTGCTGATGTGATTGATGCCATCGATCAGGTGCTGCTGCCCGGCCTGGTGGACCTGCACACCCACTTGCGCGAGCCGGGCCGCGAATATGCTGAGGACATCGAAACTGGTTCGGCAGCAGCGGCTCTTGGTGGTTACACTGCGGTTTTCGCGATGCCCAATACCACCCCTGTAGCGGACAGTCCGGTGGTTACCGACCATGTCTGGCGTCGTGGCCAGCAGGTCGGCCTGGTTGATGTGCACCCCGTCGGTGCGGTCACCGTCGGGCTGGCCGGAGCCGAGCTCACCGAGATGGGTATGATGGCTGCCGGTGCCGCACAGGTGCGGATCTTCTCCGACGATGGCAACTGTGTGCATAACCCGTTGGTGATGCGCCGTGCCCTGGAGTACGCCACTGGCCTGGGGGTGCTGATCGCTCAGCACGCCGAGGAACCGAGGCTGACTGTCGGCGCTGTTGCGCACGAGGGACCTACGGCCGCCAGGCTGGGATTGTCGGGATGGCCCAGAGCGGCCGAGGAATCAATTGTTGCCCGCGACGCCCTGTTGGCCCGTGATGCCGGCGCTCGGGTGCACATCTGCCACGCTTCTACCGCAGGAACCGTAGAGATCCTGAAATGGGCTAAAGAGCAAGGTATTTCGATAACTGCCGAGGTAACACCACATCATCTTTTGCTCGATGACAGCAGGTTAGCCAGCTACGACGGGGTGAATCGGGTCAACCCGCCGCTGCGCGAAACCGCCGACGCAGTCGCACTGCGGCAGGCGTTGGCTGATGGGATCATCGATTGTGTGACTACCGACCACGCCCCGCATGCCGATCATGAGAAGTGCGTCGAATTCTCCGCAGCGCGCCCTGGCATGCTGGGCTTGCAGACGGCGCTGTCGGTGGTGGTGCACACGATGGTGGTGCCTGGCCTATTAAGCTGGCGCGATGTCGCGCAGGTGATGAGTGAGAACCCTGCCCGCATCGCCGGGTTGCCCGATCATGGCCGGCCACTGGAGGTGGGTGAACCGGCTAACCTGACGGTGGTGGACCCGGACGTTACCTGGACGGTCACCGGCGACGGCTTGGCCAGCAGGTCAGCCAACACGCCGTACGAGGCGATGACCCTGCCCGCCACTGTGACTGCGACCCTGCTGCGCGGGAAGGTCACCGCCCGGGGTCAGAAGAGTCCGGTATGAA

Protein Sequence 

>ML0533_PyrC_protein
ACYFVVSACMARVNKSMYWLRASRSPTLVLVLIFPTLLM_LMPSIRCCCPAWWTCTPTCASRAANMLRTSKLVRQQRLLVVTLRFSRCPIPPL_RTVRWLPTMSGVVASRSAWLMCTPSVRSPSGWPEPSSPRWV_WLPVPHRCGSSPTMATVCITRW_CAVPWSTPLAWGC_SLSTPRNRG_LSALLRTRDLRPPGWDCRDGPERPRNQLLPATPCWPVMPALGCTSATLLPQEP_RS_NGLKSKVFR_LPR_HHIIFCSMTAG_PATTG_IGSTRRCAKPPTQSHCGRRWLMGSSIV_LPTTPRMPIMRSASNSPQRALACWACRRRCRWWCTRWWCLAY_AGAMSRR__VRTLPASPGCPIMAGHWRWVNRLT_RWWTRTLPGRSPATAWPAGQPTRRTRR_PCPPL_LRPCCAGRSPPGVRRVRYE

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PyrC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

28 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PyrC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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