carA
mL0535
Probable carbamoyl-phosphate synthase small chain CarA (Carbamoyl- phosphate synthetase glutamine chain). SUBUNIT: COMPOSED OF TWO CHAINS%3B THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA%2C WHICH IS USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE. Belongs to the CarA family.
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 648423 – 649550
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0535_carA_dna
TGAGCAAAGCCCTACTGGTTCTCGAAGACGGCCGCGTCTTCACCGGCATGCCGTTTGGTGCGATTGGCCAAACGTTGGGTGAAGCCGTGTTTTCCACCGGCATGTCCGGCTACCAGGAGACGTTGACCGATCCCAGTTATCACCGTCAGATCGTGGTGGCCACCGCCCCGCAGATCGGCAACACCGGCTGGAACGACCAGGACGGTGAGAGTCGCGACGATAGAATCTGGGTCGCGGGTTACGCGGTGCGTGACCCGTCTCCGTGCGCCTCGAACTGGCGCGCCACCGGCACGCTGGAAGACGAGCTGGTCCGCCAGCGTATTGTTGGGATCGCCGGTATCGACACTCGGGCGGTAGTGCGTCATCTGCGCAGATACGGTTCGATGAAGGCGGGTGTGTTTTCTGGCAAGGCAATGATCGAGCCCCTAAATATCGAGGCGCTAGTACAACATGTGCGCACCCAGCAGTCGATGCTGGGTGCTGATCTTGTTGGCGAAGCCAGCACACTGGATGCATATGTTGTTGAACCCAAAGGGAAGGAACGCTTTACGGTGGCAGCGCTTGACCTCGGGATCAAGACCAACACGCCGCGCAACTTCGCTCGGCGTGGGATTCGCAGCTATGTGCTGCCGGCGTCGGCGACGTTCAACCAAATTGCCGACATCAAACCGCATGGCCTGTTTTTGTCCAATGGCCCTGGTGACCCGGCTACCGCCGACCACGTCGTTGCGCTCACTCGAGAGGTGCTGAACGCCGGAATTCCTTTGTTCGGTATCTGTTTCGGCAACCAGATCTTGGGCCGGGCGCTAGGACTGTCGACCTACAAGATGGTCTTCGGCCACCGCGGTATCAATATACCGGTCATCGACCACGCCACCGGACGGGTCGCGGTGACCGCGCAAAACCATGGTTTCGCACTGGAAGGGGAGGCAGGCCAGTCCTTCGACACACCTTTTGGCTCAGCGGTGGTCAGTCACACCTGTGCCAACGATGGGGTGGTGGAAGGTGTCAAACTCGCTGACGGGCGTGCATTTTCGGTGCAATATCACCCGGAGGCGGCCGCCGGCCCGCACGATGCCGAGTACCTATTCGATAGTTTTGTCGAACTCATGGCAGCCCAGCGATGAC

Protein Sequence 

>ML0535_CarA_protein
AKPYWFSKTAASSPACRLVRLAKRWVKPCFPPACPATRRR_PIPVITVRSWWPPPRRSATPAGTTRTVRVATIESGSRVTRCVTRLRAPRTGAPPARWKTSWSASVLLGSPVSTLGR_CVICADTVR_RRVCFLARQ_SSP_ISRR_YNMCAPSSRCWVLILLAKPAHWMHMLLNPKGRNALRWQRLTSGSRPTRRATSLGVGFAAMCCRRRRRSTKLPTSNRMACFCPMALVTRLPPTTSLRSLERC_TPEFLCSVSVSATRSWAGR_DCRPTRWSSATAVSIYRSSTTPPDGSR_PRKTMVSHWKGRQASPSTHLLAQRWSVTPVPTMGWWKVSNSLTGVHFRCNITRRRPPARTMPSTYSIVLSNSWQPSDD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding CarA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

6 proteins show strong predicted evidence for PPIs

25 show intermediate predicted evidence for PPIs

98 show weak predicted evidence for PPIs

View all pooled AlphaFold results for CarA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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