carB
mL0536
Probable carbamoyl-phosphate synthase large subunit CarB (Carbamoyl-phosphate synthetase ammonia chain)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 649609 – 652998
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0536_carB_dna
TGCGCCCAGAAAGGGGGACGCTAGTGCCGCGGCGGACTGATCTCAACCATGTACTGGTGATCGGCTCGGGGCCGATTGTCATCGGGCAGGCCTGCGAGTTCGACTATGCTGGCACCCAGGCATGTCGAGTGCTGCGGGCCGAGGGCTTGCAAGTGAGTCTGGTCAACTCTAACCCGGCCACCATCATGACCGATCCGGAGTTCGCCGACCACACCTATGTCGAGCCGATTACGCCGGCCTTCGTGGAGCGGGTGATTGTTCAGCAGGCCGAGCGTGGCAACAGGATTGACGCTTTGCTAGCCACCTTAGGTGGGCAGACCGCGCTCAACACAGCGGTAGCGCTGTACGAAAACGGAGTGTTGGAGCGCTATGGCGTCGAGCTCATCGGTGCTGATTTCGAGGCTATCCAGCGTGGTGAGGACCGGCAGCGATTCAAAGATCTCGTCGCTAAGGTTGGTGGTGAATCCGCTCGCAGTAAAGTGTGTTTCACCATGGATGAGGTGCGTGAAACAGTCGAGGATCTTGGCCTTCCGGTGGTGGTGCGGCCAAGTTTCACGATGGGCGGATTGGGTTCGGGCATGGCTCACTCCGACGAGGAGGTTGGCCGGATGGCCGGCGCCGGGCTGGTAGCTTCACCTAGTGCCAACGTGCTGATCGAGGAATCGGTCTATGGTTGGAAGGAATTCGAACTCGAGCTAATGCGCGATGGACACGACAGCGTCGTGGTGGTGTGCTCGATCGAGAACGTTGACCCGATGGGTGTGCACACTGGTGATTCGGTCACCGTAGCACCCGCCATGACTCTGACCGACTGGGAATATCAACGTATGCGGGATCTGGGCATCGCGATCCTGCGCGAGGTCGGCGTGGACACCGGTGGCTGCAACATCCAATTTGCGATCAACCCCCATGACGGCCGGCTTATCGTCATCGAGATGAACCCACGGGTATCTCGGTCCAGTGCGTTGGCGTCCAAGGCCACCGGTTTCCCGATCGCCAAGATCGCAGTCAAGCTGGCTGTCGGCTACACGCTAGACGAGATCCTCAACGACATCACTAAAGAAACGCCGGCTTGCTTTGAGCCGGCATTGGATTACGTCGTGGTTAAGGCGCCGCGGTTCGCGTTCGAGAAATTCCCCGGCGCTGATCCCACACTAACTACTACGATGAAATCCGTCGGAGAAGCAATGTCGTTGGGCCGCAACTTTGTTGAGGCACTCGGTAAGGTGATGCGATCGTTAGAAACCGGCCGCTTCGGTTTCTGGACGGCACCCGACCCGCAGGGTGACGTCGACCAGGTGCTTCTCCGGCTGAAGACCCCGACCGAAGGCCGACTCTATGACGTCGAACTGGCGTTGCGGCTGGGTGCTTCGACTGAAAAGGTGGCACAGGTTTCCGGCATCGATCCCTGGTTCGTAGCGCAGATCGGTGAGCTGGTGAAGCTACGCGACGAGCTGGTCGCTGCCCCGGTCCTTGACGCCGAGTTGCTGCGGCGCGCTAAGCACAACGGGCTATCGGATCGACAGATTACTGCGTTACGCCCAGAATTACTGGGGGAAGACGGAGTTCGGTCGCTGCGTAAACGGCTGGGCATTCATCCGGTGTATAAGACGGTCGACACATGCGCTGCGGAGTTCGAGGCCAAAACTCCTTACCACTACAGCAGCTACGAACTAGATCCTGCCGCTGAAACGGAGGTGGTCCCGCAAACAGAGAAACCCAAGGTGCTGATCCTAGGGTCCGGCCCCAACCGCATTGGCCAGGGAATCGAATTCGACTACAGTTGTGTTCATGCAGCAATTACGTTATCGCATAATGGTTTTGAGACAGTTATGGTTAATTGCAACCCGGAGACGGTGTCCACCGACTACGACACTGCCGACCGGTTATACTTCGAGCCGCTGACGTTCGAAGATGTCCTTGAGGTGTTCTATGCCGAAGAGCAGTCTGCGGCGGGCGGTGCCGGGGTAGCCGGCGTCATTGTGCAACTCGGCGGCCAGACCCCGCTCGGGCTTGCACAACGGCTCGCCGATGCCGGGGTTCCTATCGTGGGCACTTCGCCGGAGGCCATTGATCTTGCCGAAGATCGCGGAGCGTTCGGAGACGTGCTGACAGCCGCCGGGCTGCCGGCGCCAAAATATGGAACTGCAACAACTTTCGCTCAAGCACGCCGTATCGCTGCTGAGATTGGCTATCCGGTTTTAGTGAGGCCCTCGTATGTGCTGGGCGGTCGCGGTATGGAGATCGTCTACGACGAGGAGACACTGAAGGATTACATCACGCGTGCTACCGCGCTGTCACACGAGCATCCGGTGCTGGTGGACCGCTTTCTCGAGGATGCGGTTGAGATCGACGTCGACGCACTGTGCGACGGCACCGAGGTGTACATCGGCGGAGTCATGGAGCACATAGAGGAAGCCGGTATCCACTCCGGTGATTCGGCTTGCGCGCTTCCCCCAGTAACATTGGGTCGCAGTGACCTAGAGAAGGTGCGTCAGGCGACCGAAGCCATCGCACGCGGGATTGGCGTGGTGGGACTACTCAATGTACAATATGCTCTCAAAGAAGACGTGCTCTACGTACTGGAAGCCAACCCGCGCGCGAGCCGAACGGTGCCGTTCGTTTCCAAGGCTACTGCAATCCCGCTTGCCAAGGCTTGTGCCCGGATCATGTTGGGTTCCAGTATTTCCCAGCTTCGTTTCGAAGGGATGCTGGCGGCTTCTGGTGACGGCGGCAACGTGGCGTCGCACGCCCCGATCGCGGTCAAAGAAGCTGTGTTGCCGTTTAACCGGCTCCGGCGGGCCGACGGAGCCGCTATCGATTCCTTGCTCGGTCCGGAGATGAAATCGACCGGTGAGGTCATGGGGATCGACCACGATTTTGGCAGAGCATTCGCCAAGAGCCAGACCGCTGCGTATGGCTCGTTGCCGACTCAAGGTACGGTGTTCGTGTCGGTGGCTAACCGGGATAAGCGGTTACTGGTGTTCCCCGTCAAGCGGCTGGCTGATCTTGGATTTCATGTTATAGCCACCGAGGGAACTGCGGAGATGTTGCGTCGCAAAGGAATTCCTTGCGATGAGGTGCGCAAGCATTTCGAGCCGCCGAAAGCGGGCCGCCCCGCGTTGTCCGCGGTCGATGCGATTCGGGCCGGTGACGTGGATATGGTGATCAACACGCCCTACGGCAACTCCGGCCCGCGTATCGACGGTTATGAGATCCGCTCGGCCGCAGTCTCGGTCAATATTCCTTGCGTCACGACGGTGCAGGGTGCTTCCGCCGCGGTGCAGGGCATCGAAGCGGGGATCCGAGGTGACATCGGCGTACGGTCGCTGCAAGAACTGCACAGTGCCATTGGTGCGGGGATCGCGGCTGATAATGAGGTCCAATGAC

Protein Sequence 

>ML0536_CarB_protein
CAQKGGR_CRGGLISTMYW_SARGRLSSGRPASSTMLAPRHVECCGPRACK_VWSTLTRPPS_PIRSSPTTPMSSRLRRPSWSG_LFSRPSVATGLTLC_PP_VGRPRSTQR_RCTKTECWSAMASSSSVLISRLSSVVRTGSDSKISSLRLVVNPLAVKCVSPWMRCVKQSRILAFRWWCGQVSRWADWVRAWLTPTRRLAGWPAPGW_LHLVPTC_SRNRSMVGRNSNSS_CAMDTTASWWCARSRTLTRWVCTLVIRSP_HPP_L_PTGNINVCGIWASRSCARSAWTPVAATSNLRSTPMTAGLSSSR_THGYLGPVRWRPRPPVSRSPRSQSSWLSATR_TRSSTTSLKKRRLALSRHWITSWLRRRGSRSRNSPALIPH_LLR_NPSEKQCRWAATLLRHSVR_CDR_KPAASVSGRHPTRRVTSTRCFSG_RPRPKADSMTSNWRCGWVLRLKRWHRFPASIPGS_RRSVSW_SYATSWSLPRSLTPSCCGALSTTGYRIDRLLRYAQNYWGKTEFGRCVNGWAFIRCIRRSTHALRSSRPKLLTTTAATN_ILPLKRRWSRKQRNPRC_S_GPAPTALARESNSTTVVFMQQLRYRIMVLRQLWLIATRRRCPPTTTLPTGYTSSR_RSKMSLRCSMPKSSLRRAVPG_PASLCNSAARPRSGLHNGSPMPGFLSWALRRRPLILPKIAERSETC_QPPGCRRQNMELQQLSLKHAVSLLRLAIRF__GPRMCWAVAVWRSSTTRRH_RITSRVLPRCHTSIRCWWTAFSRMRLRSTSTHCATAPRCTSAESWST_RKPVSTPVIRLARFPQ_HWVAVT_RRCVRRPKPSHAGLAWWDYSMYNMLSKKTCSTYWKPTRARAERCRSFPRLLQSRLPRLVPGSCWVPVFPSFVSKGCWRLLVTAATWRRTPRSRSKKLCCRLTGSGGPTEPLSIPCSVRR_NRPVRSWGSTTILAEHSPRARPLRMARCRLKVRCSCRWLTGISGYWCSPSSGWLILDFML_PPRELRRCCVAKEFLAMRCASISSRRKRAAPRCPRSMRFGPVTWIW_STRPTATPARVSTVMRSARPQSRSIFLASRRCRVLPPRCRASKRGSEVTSAYGRCKNCTVPLVRGSRLIMRSND

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding CarB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

3 proteins show strong predicted evidence for PPIs

19 show intermediate predicted evidence for PPIs

81 show weak predicted evidence for PPIs

View all pooled AlphaFold results for CarB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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