PPE
mL0539
PPE-family protein
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 654435 – 656051
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0539_PPE_dna
TGACGAACCCATGGATGGCTTTCCCCCCCGAGGTACAGTCGGCGATGCTGAACTTCGGTGCAGGGGTCGGACCCATGTTGAACTCCGCCTCGTACAACTTATGGCTCAGCGCCGAGTACCGCTGGGTTGCATCAGAGGTCGAGGCATTGCTAAGGGAAGTGCGGTCCGGGGGGTGGCAGGGGCAAGCCGTCGAGATGTTTGTGGGCTCGTGTATGCCATTTCTGGCATGGCTGATGAAAGCCGCCGCCGACTACATGGACGTGGCCACTCAACAAGAGGTCGTGGCCGCGGCTTACGCCGCCGCAGTAGAGGCCATGCCGACACAATTCGAGCTGGCCGCCAACCGAGTCGTGCGTGGGGTGTTGATGGCGACCAATTTCTTTGGTGTCAACACTATCCCCATTGCGCTCAACGAGGAAGAGTATGTGCAGATGTGGGTTCGGGCCGCCACTACGATGGCGACCTATTCGGCAATCTCTCAGTCGGCATTAGCCGCGACGCCGCAGGCCACTCCCCCGCCGCTGATCCTGAAATCCAATGTGCTAGTCGATGACGTTGAGAAGGACTCTCGTCATGACGGTCACAGCCATGGCGGTCACGCCAGCGCGATGGATAGGGTGTTTGCAGACATCCTGCGTAACGTCAGCGGAGGCCGCCTAGTTTGGGACCCTCTCAATGGCACCTTGAACGGACTGGACTACGACGACTATGTCTACCCGGGTCAGCCGATCTGGTGGCTTGCTCGAGGCCTTGAGTTTTTTCAGGATGGTGAACAGTTTTGGGAACTGTTGTTTATCAATCCGACAGCGGCTTTTCAGTTCCTCCTTTACATCGTTGTGTTGGATTTGCCGACGCACATAGTCCAACTTGGTACCTGGCTGGCCGAGTATCCGCAGTTGCTGTTGGTTGCTCTCGGTGGTACCATCGCCAACCTGGGAGCGGTAACCGGCTTGGCGGGGCTATCATCTGGCCTGAGTGCCGGTCCGTCTGCTGCGATACCCACCGTTGTACCGGAGTCGGCACCCATCGCGACTGTGCCCGCTATGTTGGCGGGTGCCGGGGTGGCCCCGGCAGTCGTTGCTCCAGGTGCGTCGCCCTCCTCAGCCGCCCCACCAGCGTCGGCGGCCAGCGCCGCCGCGGCCGCCCCGGCGCCGCCGGGTACTGGTTTCGGGGGTTTTTCTCCTTACCTCGTCGACGGTCGCGGTCCAGGCGTTGGGTTCGGCTCCGGACGACAGTCGGCTTACGCCAACAAGGTCTCGGAGTCGGTCTCCGATTCCGCTGTGGCTGAGGCGGCTGCCCAGGCCTCGGCGCGTGAGCAGGCGAGGGCTTGGCGGCGGCGCTCGGCGGCGAAAGAACGTGGCTATCGTGAAGAGGTCATTACGATGAACACGGGTTTCGACGCGGCAATTCCGTCGCCAGTTGACCAGACAGGTTCCCGGGTGTCCGATTGTGGCGCGGGATCCTTCGGGTTTGCTGGAACGGTAAGCAAGGAGGCCGTTGTCGAAGTGGCCGGGTTGACTACGCTGGCTGGTGATGATTTCGGTGGCGGCCCAACGATGCCGATGGTACCGGGTACCTGGGCCCCGGCCAGGGAGTCAAGCGACGAGGGACGGTGAT

Protein Sequence 

>ML0539_PPE_protein
RTHGWLSPPRYSRRC_TSVQGSDPC_TPPRTTYGSAPSTAGLHQRSRHC_GKCGPGGGRGKPSRCLWARVCHFWHG__KPPPTTWTWPLNKRSWPRLTPPQ_RPCRHNSSWPPTESCVGC_WRPISLVSTLSPLRSTRKSMCRCGFGPPLRWRPIRQSLSRH_PRRRRPLPRR_S_NPMC_SMTLRRTLVMTVTAMAVTPARWIGCLQTSCVTSAEAA_FGTLSMAP_TDWTTTTMSTRVSRSGGLLEALSFFRMVNSFGNCCLSIRQRLFSSSFTSLCWICRRT_SNLVPGWPSIRSCCWLLSVVPSPTWER_PAWRGYHLA_VPVRLLRYPPLYRSRHPSRLCPLCWRVPGWPRQSLLQVRRPPQPPHQRRRPAPPRPPRRRRVLVSGVFLLTSSTVAVQALGSAPDDSRLTPTRSRSRSPIPLWLRRLPRPRRVSRRGLGGGARRRKNVAIVKRSLR_TRVSTRQFRRQLTRQVPGCPIVARDPSGLLER_ARRPLSKWPG_LRWLVMISVAAQRCRWYRVPGPRPGSQATRDGD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PPE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

5 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

22 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PPE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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