metK
mL0544
Probable S-adenosylmethionine synthase MetK (MAT) (AdoMet synthetase) (Methionine adenosyltransferase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 659722 – 660933
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0544_metK_dna
TGAGTGAGAAGGGTCGGCTGTTCACTAGCGAGTCGGTGACTGAGGGACATCCCGACAAGATCTGTGATGCGATCAGCGACTCGATCCTTGACGCACTTTTGGCGGAGGATCCTTGCTCACGTGTCGCGGTCGAGACGTTGGTCACCACCGGGCAGGTGCATGTGGTGGGTGAAGTGACGACGTTGGCCAAGACGGCGTTCGCTGATATCAGTAATACGGTCCGCGAACGTATTCTCGATATCGGCTACGACTCGTCGGACAAGGGCTTCGATGGGGCGTCGTGCGGAGTTAACATTGGCATCGGCGCTCAGTCGTCTGACATTGCTCAAGGCGTCAATACCGCCCATGAAGTACGCGTCGAGGGCGCGGCGGATCCGCTGGACGCCCAGGGTGCTGGTGACCAAGGCCTGATGTTCGGTTACGCGATCAATGACACCCCGGAACTGATGCCGCTACCGATTGCACTGGCCCACCGACTGGCGCGAAGGCTGACCGAGGTACGCAAGAACGGCGTGCTGCCCTACCTGCGTTCCGACGGCAAGACCCAGGTCACTATCGCCTACGAGGACAATGTCCCAGTGCGTTTGGACACTGTGGTCATCTCCACTCAGCACGCCGCTGGTGTCGACCTGGATGCCACGCTGGCTCCTGATATCCGGGAGAAGGTGCTCAACACCGTTATTGACGATCTGTCTCATGACACCTTGGATGTATCGTCGGTGCGGGTGCTGGTAAACCCGACCGGCAAGTTCGTGCTAGGTGGGCCGATGGGCGATGCCGGGCTCACCGGTCGCAAGATCATCGTCGACACCTACGGTGGCTGGGCGCGTCACGGCGGCGGCGCCTTCTCTGGCAAGGATCCGTCCAAGGTGGACCGGTCGGCAGCCTACGCGATGCGCTGGGTGGCCAAGAACATCGTCGCTGCCGGGCTGGCGGAGCGAATCGAGGTGCAGGTGGCATACGCCATCGGCAAAGCCGCCCCGGTCGGTTTGTTCGTCGAGACCTTTGGCACTGAGGCGGTCGATCCGGCCAAAATCGAGAAAGCCATCGGCGAGGTGTTCGATCTGCGTCCCGGCGCGATCATCCGCGACCTGCATCTGCTGCGCCCAATTTACGCGCAAACCGCTGCCTATGGGCACTTCGGTCGCACTGACGTCGAACTGCCATGGGAGCAGCTCAACAAAGTCGACGATCTCAAGCGCGCCATCTAGG

Protein Sequence 

>ML0544_MetK_protein
VRRVGCSLASR_LRDIPTRSVMRSATRSLTHFWRRILAHVSRSRRWSPPGRCMWWVK_RRWPRRRSLISVIRSANVFSISATTRRTRASMGRRAELTLASALSRLTLLKASIPPMKYASRARRIRWTPRVLVTKA_CSVTRSMTPRN_CRYRLHWPTDWREG_PRYARTACCPTCVPTARPRSLSPTRTMSQCVWTLWSSPLSTPLVSTWMPRWLLISGRRCSTPLLTICLMTPWMYRRCGCW_TRPASSC_VGRWAMPGSPVARSSSTPTVAGRVTAAAPSLARIRPRWTGRQPTRCAGWPRTSSLPGWRSESRCRWHTPSAKPPRSVCSSRPLALRRSIRPKSRKPSARCSICVPARSSATCICCAQFTRKPLPMGTSVALTSNCHGSSSTKSTISSAPSR

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MetK with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

16 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MetK

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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