uvrC
mL0562
Probable excinuclease ABC (subunit C - nuclease) UvrC (UvrC protein) (Excinuclease ABC subunit C)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 678871 – 680814
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0562_uvrC_dna
TGCCAGATCCCGCGACGTATCGCCCCGCGACCGGATCCATCCCGGTCGAGCCTGGTGTGTACCGATTCCGGGATCCGTACGGGCGCGTCATTTACGTAGGCAAGGCCAAAAGCCTGCGTAGCCGGCTGGCATCGTATTTTGCCGACGTCGCGAACCTGCACCCGCGGACTCGGCAAATGGTGACCATTGCAGCCAAGGTCGAGTGGACAGTGGTCAACACTGAGGTTGAGGCTCTGCAGTTGGAGTACAATTGGATCAAGGAATTCGATCCGCGCTTCAACATCCGCTACCGCGACGACAAGTCCTATCCGGTATTGGCCGTCACCCTGGGTGAGGAGTTTCCTCGACTGATGGTCTATCGCGGTCCCCGGCGCAAGGGCGTGCGCTATTTCGGACCGTACTCGCACGCGTGGGCCATTCGGGAAACGCTGGATCTGCTCACCCGGGTGTTTCCAGCACGAACCTGTTCACCTGGAGTGTTCAAGCGGCACAAGCAAATCGATCGTCCATGCCTACTTGGTTACATTGACAAATGTGCGGCGCCGTGTGTGGGCAGGGTTGGTGCCGAGCAGCATAGTCAAATCGTGGCAGATTTTTGCGACTTCTTGTCCGGCAAGACCGATCGGTATGCCCGTGACTTGGAACGAAAAATGAGCGCAGCTGCAGAGCAACTCGATTTCGAACGAGCAGCCCGGCTTCGTGACGACCTTTTTGCACTCAAGCGGGCTATGGAGAAACAGGCGGTGGTGTTCGGCGATGGTACTGACGCTGACGTAGTGGCATTCGCCTACGACGAACTGGAGGTGGCGGTGCAGGTGTTCCACGTTCGCGGCGGGCGGGTGCGTGGCCAGCGCGGCTGGATTGTTGAAAAGTCCGATGACCCTGGTGATACCGGGGAGGAGCAATTGGTGGAGCAATTCCTGGCACAGTTCTATGGCGAACAGGCGGAGTTAGACTTTGTTGCAGACGAATCCGCTAACCCGGTTCCCCGCGAGGTGTTGGTGCCGTGTTTACCCTCCAACGCCGACGAGTTGGCCAGTTGGCTGTCCGGTCTGCGTGGATCCCGGGTCGCGCTGCGGGTGCCACGGCGCGGCGACAAACGTGCGCTAGCTGAGACGGTGCAGCGAAACGCGAAAGAAGAATTGCAGCAACACAAACTGAAGCGTGCCAGTGACTTTAACTCTAGATCCGCTGCGTTGCAGAATATTCAAGACACACTGGGTTTATCCTATGCACCACTGCGAATTGAATGCGTCGATATAAGCCACGTGCAGGGCACCGACGTGGTGGGCTCTCTGGTCGTATTCGAGGACGGTTTGCCGCGCAAGTCGGACTACCGACACTTCGGGATCCGGAAAGCTGCTGGGAACGGGCGCTCTGATGATGTTGCCTCCATCGCTGAGGTGACTCGACGCCGATTCCTGCAGCATCTTCACGATCAGAACGATACGAATCTGCTTTCTCCGGAAGGAAAATCACACCGATTTGCCTATCCGCCTAATCTGTATGTCGTTGACGGTGGCGCGCCACAAGTCAATGCGGCCAGCACCGTGCTTGAGGAACTCGGTATCATTGATGTGGCTGTGATTGGTCTGGCCAAGCGGCTCGAAGAGGTGTGGGTGCCGTTCGAGCCGTACCCGGTCATCATGCCGCGCAACAGCGAGGCCCTGTTTCTGCTGCAGCGGGTTCGTGATGAGGCACATCGATTTGCCATCACCTACCATCGCAGCAAGCGATCCAAGCGAATGACCGCATCGGCGCTGGATTCGGTGCCGGGGTTGGGAGCGCATCGCCGCAAAGCGCTGGTTACCCACTTCGGATCTATAGCCCGCCTCAAAGATGCCACCGTAGAACAGATCACTGCCGTTCCGGGTATCGGCGTGGCAACGGCTACTGCCGTCCTCGAGGCGCTGCGACCGGATTCATCTGAGGCCTCGGAATGAG

Protein Sequence 

>ML0562_UvrC_protein
CQIPRRIAPRPDPSRSSLVCTDSGIRTGASFT_ARPKACVAGWHRILPTSRTCTRGLGKW_PLQPRSSGQWSTLRLRLCSWSTIGSRNSIRASTSATATTSPIRYWPSPWVRSFLD_WSIAVPGARACAISDRTRTRGPFGKRWICSPGCFQHEPVHLECSSGTSKSIVHAYLVTLTNVRRRVWAGLVPSSIVKSWQIFATSCPARPIGMPVTWNEK_AQLQSNSISNEQPGFVTTFLHSSGLWRNRRWCSAMVLTLT_WHSPTTNWRWRCRCSTFAAGGCVASAAGLLKSPMTLVIPGRSNWWSNSWHSSMANRRS_TLLQTNPLTRFPARCWCRVYPPTPTSWPVGCPVCVDPGSRCGCHGAATNVR_LRRCSETRKKNCSNTN_SVPVTLTLDPLRCRIFKTHWVYPMHHCELNASI_ATCRAPTWWALWSYSRTVCRASRTTDTSGSGKLLGTGALMMLPPSLR_LDADSCSIFTIRTIRICFLRKENHTDLPIRLICMSLTVARHKSMRPAPCLRNSVSLMWL_LVWPSGSKRCGCRSSRTRSSCRATARPCFCCSGFVMRHIDLPSPTIAASDPSE_PHRRWIRCRGWERIAAKRWLPTSDL_PASKMPP_NRSLPFRVSAWQRLLPSSRRCDRIHLRPRNE

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding UvrC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

3 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

53 show weak predicted evidence for PPIs

View all pooled AlphaFold results for UvrC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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