ML0593
mL0593
Conserved hypothetical protein
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 718689 – 721298
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0593_ML0593_dna
TGACACGCACGTCAGAGACTACGAAGTCGCCGGCTCCCGAGTTGTTGACCCAGCAGCAGGCAATCGACTCGCTGGGTAAATACGGTTACGGGTGGGCGGATTCCGACGTCGCGGGCGCCAGCGCGCGGCGCGGGCTCTCCGAAGATGTTGTTCGGGACATATCAGCGAAAAAGGATGAGCCGGAATGGATGCTGCAGGCCAGGCTAAAGGCGTTGCGTGTCTTTGAGCGTAAGCCCATGCCGCGCTGGGGTTCCAATCTCGATGGGATCGATTTCGACAACATCAAGTACTTCGTGCGCTCTACCGAGAAGCAGGCCGCCAGCTGGGATGAGCTGCCAGAAGACATCCGCAACACCTACGACCGGCTAGGAATCCCGGACGCGGAAAAGCAGCGTCTCGTTGCCGGCGTAGCGGCGCAATACGAGTCAGAGGTAGTTTACCACCAAATCAGAGCGGACTTGAAGGATCAAGGTGTCGTCTTCCTCGACACAGAAACGGGTTTGCGGGAATACCCTGACATCTTCAAGCAGTACTTAGGCACTGTGATCCCGGCGGGCGATAATAAGTTTTCCGCATTGAATACGGCAGTGTGGAGTGGCGGGTGTCTAACCGCCGATGCTCGTATTAATGTCAAGGGCAAGGGCTTGGTGAGTATTGCCGATGTCCAGCCCGGTGATGAAGTGTTTGGTGTAAATATTGGATGCGAACTCGAGCGTGGCAAAGTGTTGGCTAAGGTGGCAAGCGGCACCAAGCCCGTATACGAGATGCACGTTGCAGGTCGGGCCCTCGAAGCAACCGGAAACCATCAATTCTTAGTGGCAAGGAGAGTCGAGGAGGGTAAGCGCACACGGTGGACGGCCGTTTGGGCACCACTCGAGGAGATTGAGTCGGGTGAGCCGATCGCGGTCGCTCGCGTGTTGCCCGACGATAGCGGAACCATTTTCTTCTCCGAGTCGGAACTGGACATCAAGAACCGAACCCGGCAGTGTCTCTATTTTCCATGCCAGAACAGCGTTGATCTGCTTTGGCTCTTGGGATTGTGGCTAGGTGATGGTCATACCGCTGCACCGCATAAGCACATGCGGCAAGTCGCGTTCTCGGTCCCTGCAGGTGATCCAGTGCATCACACTGCCATCCGGGTGGTGAGTGAACAGTTCGGTGCCAACGTCACAGTGGTGAATTGTGGATTCATCGTGAGTTCCAAGGCTTTCGAGACATGGCTTGCAGAACTTGGATTTTCCGGAGACGAGAAAACCAAGCGGCTGCCTGCCTGGATTTATAGCTTGCCGCATGAGCACCAGCTCGCGCTTATTGGCGGACTGGTCGATGCTGATGGTTGGACCGAGAGCAGTGGTGCCACCATGTCGATCGCGTTTGCCAGCCGGGAGCTGCTCGAAGACGTCAGGCAACTTGCTATCGGTTGCGGGCTATACCCCGACGGGGCGCTCGTTGAGCGAACACGGAGTGCAACCTGCAGGGACGGTCGCATCGTCACGAGCACGAGTTGGCGGTTGCGGATTCAGGGCAGTCTCGACCGAGTAGGTACTCGTACACCTGGCAAGCGAGGGAAACCGGTGAGCAACAAGGGGAGAAGACAGCGGTATGTTGCTGCCGCTGGGCTTAATTTCTCGTCATTGTCCACCGATACCGTCGGCTTCGCACGTTTGAAGAGTAAGACGCTGGTGGGCGAGAAGCCCACCTACGACATCCAGGTTGTGGGTTTGGAGAATTTCGTTGCAAACGGGATCGTGGCGCACAACAGCTTCATTTATGTCCCGCCGGGTGTGCACGTTGATATCCCGCTGCAAGCCTATTTCCGGATCAATACCGAGAACATGGGTCAGTTCGAGCGGACGTTGATCATCGCCGATACGGGCTCGTACGTGCATTACGTTGAGGGTTGTACCGCACCAATCTACAAGTCGGACTCGCTGCACTCCGCGGTGGTCGAAATCATCGTGAAACCGCATGCTCGCGTTCGCTATACGACCATCCAGAACTGGTCGAACAACGTCTACAACTTAGTCACCAAGCGCGCCCGTGTTGAAACGGGTGCCACCATGGAGTGGATCGACGGCAACATCGGGTCTAAGGTCACCATGAAGTACCCGGCGGTTTGGATGACCGGTGAACACGCCAAAGGTGAGGTGTTGTCAGTGGCGTTCGCTGGTGAAGGCCAGCACCAGGATACCGGGGCCAAGATGCTGCACCTGGCGTCGAACACGTCGAGTAATATTGTGTCCAAGTCGGTGGCCCGAGGTGGGGGCCGCACCTCCTACCGTGGTCTGGTGCAGGTTAATAAAGGTGCACACGGGTCGCGCTCCAGCGTAAAATGCGATGCGCTGCTGGTTGATACGATCAGCCGCAGTGACACGTATCCGTACGTCGATATCCGCGAAGACGACGTCACGATGGGCCATGAGGCCACCGTCTCGAAGGTCAGCGAGAACCAGTTGTTCTACTTGATGAGCCGTGGGTTGGCCGAGGATGAGGCAATGGCGATGGTGGTGCGCGGCTTCGTCGAGCCGATAGCCAAGGAGCTACCGATGGAGTACGCGCTGGAACTCAACCGATTGATCGAATTGCAGATGGAGGGTGCGGTCGGATGAC

Protein Sequence 

>ML0593_ML0593_protein
HARQRLRSRRLPSC_PSSRQSTRWVNTVTGGRIPTSRAPARGAGSPKMLFGTYQRKRMSRNGCCRPG_RRCVSLSVSPCRAGVPISMGSISTTSSTSCALPRSRPPAGMSCQKTSATPTTG_ESRTRKSSVSLPA_RRNTSQR_FTTKSERT_RIKVSSSSTQKRVCGNTLTSSSST_AL_SRRAIISFPH_IRQCGVAGV_PPMLVLMSRARAW_VLPMSSPVMKCLV_ILDANSSVAKCWLRWQAAPSPYTRCTLQVGPSKQPETINS_WQGESRRVSAHGGRPFGHHSRRLSRVSRSRSLACCPTIAEPFSSPSRNWTSRTEPGSVSIFHARTALICFGSWDCG_VMVIPLHRISTCGKSRSRSLQVIQCITLPSGW_VNSSVPTSQW_IVDSS_VPRLSRHGLQNLDFPETRKPSGCLPGFIACRMSTSSRLLADWSMLMVGPRAVVPPCRSRLPAGSCSKTSGNLLSVAGYTPTGRSLSEHGVQPAGTVASSRARVGGCGFRAVSTE_VLVHLASEGNR_ATRGEDSGMLLPLGLISRHCPPIPSASHV_RVRRWWARSPPTTSRLWVWRISLQTGSWRTTASFMSRRVCTLISRCKPISGSIPRTWVSSSGR_SSPIRARTCITLRVVPHQSTSRTRCTPRWSKSS_NRMLAFAIRPSRTGRTTSTT_SPSAPVLKRVPPWSGSTATSGLRSP_STRRFG_PVNTPKVRCCQWRSLVKASTRIPGPRCCTWRRTRRVILCPSRWPEVGAAPPTVVWCRLIKVHTGRAPA_NAMRCWLIRSAAVTRIRTSISAKTTSRWAMRPPSRRSARTSCST__AVGWPRMRQWRWWCAASSSR_PRSYRWSTRWNSTD_SNCRWRVRSDD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding ML0593 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

3 proteins show strong predicted evidence for PPIs

5 show intermediate predicted evidence for PPIs

50 show weak predicted evidence for PPIs

View all pooled AlphaFold results for ML0593

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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