folD
mL0674
Probable bifunctional protein fold: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase FolD
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 810693 – 811541
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0674_folD_dna
TGGGTGCAATCACGCTGGACGGCAAGGCCACCCGAGACGAGATCCTGATCGACCTCAAGCAACGCGTGGCCGCATTAACCGAATCCGGTCGCACGCCCGGACTGGGTACCATCCTGGTCGGTGACGACCCCGGATCACATGCCTATGTTCGTGGCAAGCACGCCGACTGTGCGAAGGTGGGCATCACATCGATTCGCCGCGACTTGCCCGTCGACATCACAACGGCCGTGCTGCATGACACCATCGAGGAACTGAATGCCAACCCCGACTGCACCGGCTATATCGTGCAGTTGCCGTTACCCAAGTACCTGGACGAGAACACGGCGCTGGAGCGTGTCGACCCGGCCAAGGATGCCGACGGCCTGCACCCGACGAACCTCGGCCGGCTAGTGCTGTCCACCCCGGCGCCGCTGCCGTGTACCGCGCGTGGCATTTTGCACCTGCTACGGCGTTACGGCGTCGAGATCGCCGGAACACACGTCGTCATCATCGGGCGCGGTGTTACGGTTGGTCGCCCGTTGGGGCTGCTGCTGACACGCCGTTCCGAGAACGCCACGGTGACTTTGTGCCACACAGGAACGCGCAATCTGGCAGCGCTAACCAAGCAGGCTGACATCATTGTAGCCGCCGTCGGTGTTCCACATCTGCTGACCGCGGATATGGTGCGTCCCGGAGCTGTGGTGGTCGACGTCGGTGTCAGCCGGGTCGAGACTAGGCTCGTCGGCGACGTGCATCCGGATGTCTGGGAAGTCGCCGGTCACGTCTCACCGAATCCTGGTGGCGTTGGTCCGCTTACCCGGGTGTTTCTGCTGACCAACGTTGTCGAATTGGCCGAGGGACGGCAGTAAA

Protein Sequence 

>ML0674_FolD_protein
WVQSRWTARPPETRS_STSSNAWPH_PNPVARPDWVPSWSVTTPDHMPMFVASTPTVRRWASHRFAATCPSTSQRPCCMTPSRN_MPTPTAPAISCSCRYPSTWTRTRRWSVSTRPRMPTACTRRTSAG_CCPPRRRCRVPRVAFCTCYGVTASRSPEHTSSSSGAVLRLVARWGCC_HAVPRTPR_LCATQERAIWQR_PSRLTSL_PPSVFHIC_PRIWCVPELWWSTSVSAGSRLGSSATCIRMSGKSPVTSHRILVALVRLPGCFC_PTLSNWPRDGSK

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding FolD with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

10 show weak predicted evidence for PPIs

View all pooled AlphaFold results for FolD

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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