sdhA
mL0697c
Probable succinate dehydrogenase (flavoprotein subunit) SdhA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 834667 – 836421
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0697c_sdhA_dna
TTTGATCCAGCAACACCGATACGACGTGGTGATCGTCGGCGCAGGCGGTGCCGGAATGCGGGCAGCCGTAGAAGCCGGCCCCCGAGTGCGAACCGCGGTCTTGACGAAACTTTATCCGACCCGCAGCCACACCGGTGCCGCCCAAGGGGGCATGTGCGCGGCGCTGGCTAACGTCGAAGATGACAACTGGGAATGGCACGCCTTCGACACCGTCAAGGGTGGCGACTACCTTGCGGACCAGGACGCAGTGGAGATTATGTGCAAGGAAGCTATCGACGCGGTGCTCGACCTAGAGAAGATGGGGATGCCATTCAATCGTACCCCCGAAGGCCGCATCGATCAGCGCCGCTTCGGCGGTCACACTCGCGACCACGGCAAAGCGCCGGTCCGCAGGGCCTGCTACGCGGCCGACCGCACCGGCCACATGATCCTGCAGACGCTCTACCAGAACTGCGTCAAGCACGACGTGGAGTTCTTCAACGAGTTCTACGCACTCGACTTGGTCCTGACCCAAACCCCGAGCGGCCCAGTTACCACCGGGGTAGTGGCCTACGAGTTGGCGACCGGCGATATTCACGTCTTCCACACCAAGGCCGTCGTGATCGCGACCGGCGGTTCGGGCCGAATGTACAAGACCACCTCCAATGCGCACACGCTGACAGGAGACGGCATCGGGATTGTGTTCCGTAAGGGACTTCCTTTGGAGGACATGGAGTTTCATCAGTTTCACCCGACAGGCCTGGCAGGGCTGGGCATCCTAATATCCGAGGCGGTGCGCGGCGAAGGCGGACGGCTGCTCAACGGCGAGAACGAACGGTTCATGGAGCACTATGCCCCGACAATCGTCGACCTGGCTCCGCGTGACATCGTGGCCCGCTCAATGGTGCTCGAGGTCCTGGAGGGCCGCGGCGCTGGCCCGCATAAGGACTACGTCTACATCGATGTCCGTCACCTCGGCGAGGAGGTGCTAGAATCCAAACTTCCCGATATCACCGAATTCTCCCGCACCTATTTGGGTGTGGACCCGGTCCACGAGCTGGTCCCAGTCTATCCGACCTGCCATTACGTGATGGGCGGGATCCCGACCACCGTGACCGGGCAGGTGCTGCGGGACAATACCTCGACCGTCCCCGGCCTGTACGCGGCCGGCGAATGCGCATGTGTGTCCGTGCACGGCGCCAACCGGCTGGGCACCAACTCGCTGCTAGACATCAACGTCTTCGGTCGCCGGTCCGGCATCGCAGCGGCCAGTTATGCTTCAGCCAACGACTTCGTCGATATGCCACCGAACCCAGCGGAGATGGTCATCAGCTGGGTAGCTAACATCTTATCCGAGCACGGCAACGAGCGCGTCGCCGATATTCGTGGCGCGCTACAACAGACGATGGACAACAATGCGGCGGTGTTTCGTACCGAAGAAACACTCAAGCAAGCGCTCACCGATATTCATTCGCTCAAGGAGCGATACTCCCGAATAACCGTGCACGACAAGGGAAAAAGTTTCAACAGCGACTTGTTGGAAGCCATCGAGCTGGGCTTTTTGCTGGAACTGGCTGAAGTCACGGTGGTTGGCGCGCTGAACCGCAAGGAATCCCGTGGCGGGCATGCCCGCGAAGACTATCCGCACCGGGATGACACCAACTACATGCGCCACACCATGGCGTACAAGCAAGGCACCGATCTGCTCAGCGATATCGCGCTGGATTTCAAACCCGTCGTGCAGACTCGCTACGAGCCCCAAGAACGGAAGTACTG

Protein Sequence 

>ML0697c_SdhA_protein
FDPATPIRRGDRRRRRCRNAGSRRSRPPSANRGLDETLSDPQPHRCRPRGHVRGAG_RRR_QLGMARLRHRQGWRLPCGPGRSGDYVQGSYRRGARPREDGDAIQSYPRRPHRSAPLRRSHSRPRQSAGPQGLLRGRPHRPHDPADALPELRQARRGVLQRVLRTRLGPDPNPERPSYHRGSGLRVGDRRYSRLPHQGRRDRDRRFGPNVQDHLQCAHADRRRHRDCVP_GTSFGGHGVSSVSPDRPGRAGHPNIRGGARRRRTAAQRRERTVHGALCPDNRRPGSA_HRGPLNGARGPGGPRRWPA_GLRLHRCPSPRRGGARIQTSRYHRILPHLFGCGPGPRAGPSLSDLPLRDGRDPDHRDRAGAAGQYLDRPRPVRGRRMRMCVRARRQPAGHQLAARHQRLRSPVRHRSGQLCFSQRLRRYATEPSGDGHQLGS_HLIRARQRARRRYSWRATTDDGQQCGGVSYRRNTQASAHRYSFAQGAILPNNRARQGKKFQQRLVGSHRAGLFAGTG_SHGGWRAEPQGIPWRACPRRLSAPG_HQLHAPHHGVQARHRSAQRYRAGFQTRRADSLRAPRTEVL

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding SdhA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

13 show intermediate predicted evidence for PPIs

67 show weak predicted evidence for PPIs

View all pooled AlphaFold results for SdhA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

You do not have permission to view notes.