manB
mL0753
Probable D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-ALPHA-D-HEPTOSE-1-PHOSPHATE GUANYLYLTRANSFERASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 895478 – 896554
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0753_manB_dna
TGGCAACCTTGCAAGTCGATGCGGTGGTCCTGGTCGGCGGCAAGGGCACCCGGCTGCGGCCGCTGACCTTGTCTGCGCCCAAGCCCATGCTGCCCACCGCCGGGTTGCCGTTTCTTACTCATCTGCTGTCGCGGATCGCTGCGGCGGGCATTGAGCACGTGATTCTGAGTACCTCATATCGGGACGCAGTGTTTGAGGCGGAGTTCGGCGATGGGTCCAAGCTGGGCCTGCAAATCGACTACGTGATTGAGGAGTCTCCGCTGGGAACTGGAGGTGGTATCGCCAACGTCATCGATCAGCTGCGTCACGACACCGTCATGGTGTTCAACGGCGATGTGTTGTCCGGTGTTGACCTCGGGCAGTTGCTGGGATTCCAACGAACCAACTTCGCTGACGTCACTTTGCACCTGGTGCGAGTGGGTGACCCACGGGCTTTCGGTTGTGTGTCCACCGAAGATGGTCGAGTTACCGCCTTTCTGGAGAAAACGCAAGATCCGCCTACCGACCAGATTAACGCCGGCTGTTACGTCTTCGAGCGCAATGTTATCGACCGGATTCCTCGAGGCCGTGAGGTATCGGTTGAACGCGAGGTGTTCCCGACCCTACTCTCCGACGCCGACGTTAAGGTCTGTGGTTACGTTGATGCCACGTATTGGCGGGACATGGGTACCCCAGAAGACTTTGTTCGCGGGTCGGCGGATCTGGTGCGCGGCATTGCCCCATCACCGGCCTTGGGCGGCCACCGCGGCGAGCACTTAGTGCATGACGGTGCGGCGGTGTCTCCTGGTGCGGTGCTGATCGGCGGCACGGTTGTTGGGCGTGGTGCTGAGATCGGCCCCGGTGTCCGGTTAGACGGAGCGGTGATTTTTGACGGGGCCAAGGTTGAGGCCGGCAGTGTGATCGAGCGCTCGATCCTCGGCTTCGGTGTCCGCATTGGGCCGCGGGCACTGATACGCGACGGTGTAATTGGAGACGGCGCTGATATCGGTGCGCGTTGTGAGTTGTTGCGTGGTGCTCGAGTGTGGCCCGGTGTTTCGATTCCCGACGGCGGGATTCGTTACTCCTCCGATGTCTAGC

Protein Sequence 

>ML0753_ManB_protein
WQPCKSMRWSWSAARAPGCGR_PCLRPSPCCPPPGCRFLLICCRGSLRRALST_F_VPHIGTQCLRRSSAMGPSWACKSTT_LRSLRWELEVVSPTSSISCVTTPSWCSTAMCCPVLTSGSCWDSNEPTSLTSLCTWCEWVTHGLSVVCPPKMVELPPFWRKRKIRLPTRLTPAVTSSSAMLSTGFLEAVRYRLNARCSRPYSPTPTLRSVVTLMPRIGGTWVPQKTLFAGRRIWCAALPHHRPWAATAAST_CMTVRRCLLVRC_SAARLLGVVLRSAPVSG_TER_FLTGPRLRPAV_SSARSSASVSALGRGH_YATV_LETALISVRVVSCCVVLECGPVFRFPTAGFVTPPMSS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding ManB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

23 show weak predicted evidence for PPIs

View all pooled AlphaFold results for ManB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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