gpsI
mL0854
BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (POLYNUCLEOTIDE PHOSPHORYLASE) (PNPASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1013842 – 1016163
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0854_gpsI_dna
TCTGTAGCTGAAATCGAAGAGGGCGTGTTCGAGGCAACCGTTACTATCGATAACGGGAGTTTCGGCACCCGCGCCATCCGTTTTGAGACCGGGCGCTTAGCCTTGCAAGCCGCTGGCGCAGTGGTGGCCTACCTGGACGCCGACAATATGCTCTTGTCGGCGACCACCGCCAGCAAGAACCCCAAGGAGCAATTCGACTTCTTCCCGCTTACGGTCGATGTTGAGGAGCGGATGTATGCTGCCGGTAGGATCCCTGGTTCGTTCTTCCGCCGTGAGGGTCGGCCGTCCACCGACGCGATCCTTACCTGCCGGCTCATCGATCGCCCTTTGCGCCCGTCTTTTGTCGACGGCCTGCGCAACGAGATCCAGGTCGTGGTGACGATTCTGAGCGTGGATCCCAACGATCTCTATGATGTGTTGGCCATCAATGCTGCCTCGGCCTCCACTCAGCTGGGCGGTCTACCGTTCTCCGGGCCTATCGGCGGTGTGCGGGTGGCGCTCATCGACGGTACCTGGGTTGCTTTCCCCACTGTAGAGCAGCTCGAGCGGGCCGTGTTCGACATGGTGATTGCCGGCCGGATTGTTGGCACGGATGACGAGGGCAAGCCTGATGTCGCTATCATGATGGTCGAGGCTGAGGCTACCGAAAACGTCATCGAGCTGGTCGAGTGCGGTGCTCAGGCGCCGACGGAAAGCATCGTGGCCCAAGGACTCGAGGTGGCCAAGCCGTTCATTGCTGCGCTGTGTACCGCGCAGCAGGAACTTGCTGACGTTGTGTCTTCTCGCCAAGCCAAACCGCCAGTCGAGTACCCGACGTTCCCCGACTACGGCGACGACGTCTACTACTCGGTGGCTTCGATGGCTACCGATGAGTTGGCCGCGGCCTTGACCATCGGCGCCAAGCTTGAGCGCGATCAACGCACCAACGAGATCAAGACCCAGGTTCTCGAGCGGCTCGCCGGCACCTACGAGGGCCGGGAAAAGGAGTTGGGCGCAGCATTCCGTTCGTTGACCAAGAAACTGGTCCGACAGCGGATCCTCACCAACCATTTCCGTATCGACGGCCGCGGGATCACCGACATTCGCGCGTTGTCGGCCGAAGTTGCGGTGGTTCCGCGGGCGCACGGTAGCGCGCTGTTCGAGCGCGGCGAAACCCAGATCCTTGGCGTGACCACGCTCGACATGGTCAAGATGGCTCAGCAGATCGACTCGCTGGGGCCAGAAACATCCAAGCGGTATATGCACCACTACAACTTCCCGCCGTTCTCCACTGGTGAGACTGGTCGAGTCGGCTCGCCCAAGCGGCGTGAGATCGGGCACGGTGCGCTGGCTGAGCGGGCTCTAGTGCCGGTGCTACCCAGCGTCGAGGAGTTCCCGTACGCCATCCGTCAGGTGTCCGAGGCGCTGGGTTCTAACGGCTCGACCTCGATGGGGTCGGTTTGCGCTTCCACGCTGGCGCTGCTCAACGCCGGCGTGCCGCTCAAGGCGCCGGTGGCTGGCATTGCTATGGGGCTGGTCTCCGACGATGTTGAGTTTGACGGAGGGACTGAGCGTCGTTTTGTCACCTTGACCGACATCCTGGGCGCCGAAGACGCCTTCGGCGACATGGATTTTAAATGCGCCGGTACCAAGGACTTTGTCACCGCGCTGCAGCTCGATACCAAACTTGACGGTATTCCCTCCCAGGTGCTCGCGGGTGCGCTTGCGCAGGCCAAAGACGCCCGGCTGACCATCCTCGAGGTCATGGCTGAGGCCATTGACAGACCCGACGAGATGAGCCCGTATGCGCCGCGGGTCATCACTATCAAGGTTCCAGTGGATAAGATCGGTGAAGTCATCGGCCCCAAGGGCAAGGTCATCAACGCCATTACCGAGGAGACCGGTGCGCAGATTTCTATCGAGGATGACGGTACTGTGTTCGTCGGTGCGACCGATGGCCTGTCGGCGCAGGCCGCGATCAATAAGATTAATGCCATCGCGAACCCGCAGCTGCCGACGGTCGGCGAACGGTTCCTTGGAACTGTCGTAAAGATAACGGAATTCGGCGCTTTCGTGTCGCTGCTGCCTGGGCGTGACGGTTTGGTTCACATCTCCAAGCTTGGCAAGGGTAAGCGCATCGCAAAGGTGGAAGACGTCGTGAACGTCGGTGATAAGTTGCGCGTCGAGATCGCAGATATCGAAAAACGCGGCAAGATCTCATTGGTCTTGGTGGCTGACGACGATTCGGCCACCGTCCCTGCAGCTCCGGCCGATGCTGGGGCTGCTCAGGAGTTCGGTTCGGGTACTGCGCCAGCCGATGCTGCGACGGCCAGTAGCTGACCC

Protein Sequence 

>ML0854_GpsI_protein
SVAEIEEGVFEATVTIDNGSFGTRAIRFETGRLALQAAGAVVAYLDADNMLLSATTASKNPKEQFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVVTILSVDPNDLYDVLAINAASASTQLGGLPFSGPIGGVRVALIDGTWVAFPTVEQLERAVFDMVIAGRIVGTDDEGKPDVAIMMVEAEATENVIELVECGAQAPTESIVAQGLEVAKPFIAALCTAQQELADVVSSRQAKPPVEYPTFPDYGDDVYYSVASMATDELAAALTIGAKLERDQRTNEIKTQVLERLAGTYEGREKELGAAFRSLTKKLVRQRILTNHFRIDGRGITDIRALSAEVAVVPRAHGSALFERGETQILGVTTLDMVKMAQQIDSLGPETSKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSVEEFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDVEFDGGTERRFVTLTDILGAEDAFGDMDFKCAGTKDFVTALQLDTKLDGIPSQVLAGALAQAKDARLTILEVMAEAIDRPDEMSPYAPRVITIKVPVDKIGEVIGPKGKVINAITEETGAQISIEDDGTVFVGATDGLSAQAAINKINAIANPQLPTVGERFLGTVVKITEFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIEKRGKISLVLVADDDSATVPAAPADAGAAQEFGSGTAPADAATASS_P

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding GpsI with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

16 show weak predicted evidence for PPIs

View all pooled AlphaFold results for GpsI

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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