metE
mL0961c
PROBABLE5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE METE (methionine synthase%2C vitamin-B12 independent isozyme)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1127780 – 1130062
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0961c_metE_dna
CAAATGGACGAACTCGTGACCACTCAATCATTCACCGCAACCGTAACTGGCTCTCCACGCATTGGCCCGCGCCGCGAACTTAAACGGGCGACCGAAGGCTATTGGGCCAAGCGTACCAGCCGATCAGAACTGGAGTCCGTCGCCTCAACATTGCGCCGCGACATGTGGTCGGACTTAGCCGCCGCCGGCCTGGACTCCGTACCGGTGAACACCTTCTCTTACTACGACCAGATGCTCGACACGGCATTCATGCTCGGCGCGCTGCCTGCCCGGGTAGCACAAGTGTCCGACGACCTAGATCAGTACTTCGCCCTCGCACGCGGCAACAACGACATCAAGCCGCTGGAGATGACTAAGTGGTTCGACACCAACTACCACTACCTGGTTCCTGAAATCGAGCCCGCGACCACCTTCTCACTGAACCCAGGCAAGATACTCGGTGAGCTGAAAGAAGCACTTGAGCAAAGAATTCCGTCCCGACCGGTCATTATCGGTCCGGTCACCTTCCTGTTACTGAGCAAGGGCATCAATGGCGGGGGCGCACCGATACAGCGGCTCGAGGAGCTGGTGGGAATCTACTGCACGCTGCTATCACTGCTCGCCGAGAATGGCGCACGATGGGTACAGTTCGACGAGCCGGCGCTGGTGACTGATCTATCCCCCGATGCACCGGCGTTGGCGGAAGCAGTTTACACTGCACTCGGCTCAGTTAGCAAACGACCCGCCATTTACGTGGCCACTTACTTCGGTAACCCCGGCGCTTCCTTGGCGGGGCTAGCCCGCACGCCCATCGAGGCGATCGGTGTCGACTTCGTTTGTGGTGCCGACACGTCGGTCGCGGCGGTGCCCGAGCTGGCCGGCAAGACTCTGGTGGCTGGCATCGTCGACGGACGCAACATCTGGCGCACTGACCTGGAATCGGCGTTGAGCAAGTTGGCTACTCTGCTGGGTTCAGCAGCCACCGTTGCTGTTTCGACGTCGTGCTCTACGCTGCATGTGCCGTATTCGTTGGAACCAGAAACCGACCTGGACGACAATTTGCGCAGCTGGCTGGCGTTCGGTGCGGAAAAGGTGGCCGAAGTCGTTGTGCTGGCACGCGCACTTCGCGACGGGCGCGACGCGGTCGCCGATGAGATCGCGGCGTCCAATGCCGCCGTTGCCTCGCGACGCAGCGACCCGCGGCTGCACAACGGGCAGGTACGCGCGCGTATTGACTCGATTGTCGCTTCCGGTACGCACCGCGGTGACGCAGCGCAGCGCCGCACCAGCCAGGACGCGCGCCTACACTTACCGCCGCTGCCGACCACGACGATCGGCTCCTACCCGCAGACCTCAGCGATCCGCAAAGCGCGAGCGGCACTGCAGGACGCTGAGATCGACGAGGCCGAGTACATCAGCAGGATGAAAAAAGAAGTCGCCGACGCCATCAAACTGCAGGAGCAACTCGGGCTAGATGTACTGGTCCATGGCGAGCCGGAGCGCAACGACATGGTACAGTATTTCGCTGAGCAACTGGGCGGCTTCTTCGCCACGCAGAACGGTTGGGTGCAGTCCTACGGCAGCCGTTGTGTACGTCCGCCGATCCTCTACGGTGACGTGTCCCGGCCTCACCCGATGACAATCGAGTGGATCACCTACGCGCAGTCCCTAACTGACAAGCCAGTTAAGGGCATGTTGACCGGACCGGTCACGATCTTAGCCTGGTCGTTTGTTCGTGACGACCAGCCGCTGGCCGATACCGCGAACCAAGTAGCACTGGCGATTCGCGATGAGACCGTAGATCTACAATCCGCCGGTATCGCAATCATCCAGGTTGACGAGCCCGCGCTACGTGAGCTGCTGCCGCTGCGTAGGGCTGATCAAGACGAATACTTATGTTGGGCAGTAAAGGCTTTCCGCCTAGCTACCTCGGGGGTCGCCGACTCGACGCAAATCCACACTCATCTGTGCTACTCCGAGTTCGGCGAAGTGATTGGAGCTATCGCCGACCTGGACGCCGACGTCACATCCATCGAAGCGGCGCGCTCACACATGGAAGTATTGGATGACCTGAACGCAGTCGGCTTCGCTAACAGCATAGGCCCGGGAGTCTACGACATCCACTCGCCGCGGGTACCAAGCACTGACGAGATTGCCAAGTCGCTACGCGCAGCATTAAAAGCCATACCGATGCAACGGCTTTGGGTTAACCCCGACTGCGGGCTGAAGACCCGATCAGTTGACGAGGTGAGCGCGTCGCTGCAGAACATGGTCGCAGCAGCACGCCAGGTGCGGGCAGGGGCC

Protein Sequence 

>ML0961c_MetE_protein
QMDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFALARGNNDIKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELAGKTLVAGIVDGRNIWRTDLESALSKLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDNLRSWLAFGAEKVAEVVVLARALRDGRDAVADEIAASNAAVASRRSDPRLHNGQVRARIDSIVASGTHRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAIIQVDEPALRELLPLRRADQDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVRAGA

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MetE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

43 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MetE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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