sigA
mL1022c
RNA polymerase sigma factor SigA
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1189188 – 1190912
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1022c_sigA_dna
CCGGTGGAACAGTCCAGGCGCGTGCCACCGTTACAATGGTTATCGGCGGTCGCCCGACCGATAGCGCGAGTACTCACGCTGATATCAACGCCGACATTCGACATAGCAGACACTTTCGGTTATGCATGCCCAAACCCACCGGAAGTGAGTCCGACCGAAGGGGTGTATGTGGTAGCGACCAAGACAAGTCCGGCAACCGGCCAGCCGGTGAAGCGCACCGCCACCAAGACGCCCGCGACCCCCGCCAAGCGATCGACGACTAAGGCCGCAAATGGCTCCGCCCCCACAAAACGAGCCACTAGTACAGCATCTCGGGCCACCAAATCCACGACACCACCTAAAGCCTCCGGGGCAAGCGACGCTGCGAAGAAGGCCCGCACCTCGGTCAAAAGCGTCGATACAAAGGCACCGTCCGCGCAGGACCACACGACTAAAGCCTCGGCAGCCAAAGACACCCTGAACGATCCCGAAGCCACTCTGAACACCCTCGACTCCGACGCCACTGCCGACGACCTCGATGCCGAACCGGACCTCGACGTTGAGCCCAGCGAGGACATCGACATCGACATCGAAGCCGCCGACCTCGGTCTCGACGACCTCGAAGACGACGACGTAGTCACCGACATCGAACCAGGTGAAACCGAGGATGGCGAAGCTACTGCAGCCACCAAGACCGACGAAGCTTCCACCGATGATGACGAAGAGATCGTTGAGCCGACCGAAAAAGACAAGGCCTCCGGCGATTTCGTCTGGGACGAAGATGAATCCGAGGCGTTGCGTCAGGCCCGTAAGGATGCCGAGCTCACCGCATCGGCAGACTCAGTTCGCGCGTACCTCAAACAGATCGGCAAGGTGGCCCTGCTCAACGCCGAGGAAGAGGTTGAGCTGGCGAAGCGGATCGAGGCTGGCCTATACGCCACGCAGCTAATGACCGAGCTGTCTGAGCGGGGCACCAAACTACCCACCGCCCAGCGCCGCGACATGATGTGGATCTGTCGCGACGGCGATCGTGCGAAAAACCATCTGTTGGAAGCCAACCTGCGGCTGGTGGTTTCGCTGGCCAAGCGCTACACCGGCCGCGGGATGGCGTTCCTCGACCTGATACAGGAAGGCAACCTGGGCCTGATCCGGGCAGTCGAGAAGTTCGACTACACCAAGGGGTACAAGTTCTCGACGTACGCGACGTGGTGGATCCGCCAGGCCATCACCCGCGCCATGGCGGACCAAGCCCGCACCATCCGCATCCCGGTCCACATGGTCGAGGTGATCAACAAGCTCGGCCGCATTCAGCGGGAACTACTACAGGATCTGGGCCGCGAGCCCACGCCTGAAGAGCTCGCAAAAGAGATGGACATCACACCTGAGAAGGTGCTCGAGATCCAGCAATACGCTCGTGAACCAATCTCATTAGATCAGACCATCGGCGATGAGGGCGACAGCCAGCTGGGCGACTTCATCGAAGATAGTGAAGCGGTGGTGGCCGTAGACGCGGTGTCGTTTACGTTGCTGCAAGACCAGTTGCAGTCGGTGTTGGAAACACTCTCAGAACGCGAGGCCGGCGTAGTACGGCTTCGCTTCGGCCTCACTGACGGCCAGCCTCGCACCCTCGACGAAATCGGCCAGGTCTACGGCGTAACCCGCGAACGCATCCGTCAGATCGAGTCTAAGACGATGTCGAAGTTACGCCACCCCAGCCGTTCCCAGGTCTTGCGTGACTACCTTGAC

Protein Sequence 

>ML1022c_SigA_protein
PVEQSRRVPPLQWLSAVARPIARVLTLISTPTFDIADTFGYACPNPPEVSPTEGVYVVATKTSPATGQPVKRTATKTPATPAKRSTTKAANGSAPTKRATSTASRATKSTTPPKASGASDAAKKARTSVKSVDTKAPSAQDHTTKASAAKDTLNDPEATLNTLDSDATADDLDAEPDLDVEPSEDIDIDIEAADLGLDDLEDDDVVTDIEPGETEDGEATAATKTDEASTDDDEEIVEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGTKLPTAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding SigA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

7 proteins show strong predicted evidence for PPIs

5 show intermediate predicted evidence for PPIs

32 show weak predicted evidence for PPIs

View all pooled AlphaFold results for SigA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

You do not have permission to view notes.