hemE
mL1043
PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME (UROPORPHYRINOGEN III DECARBOXYLASE) (URO-D) (UPD)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1208220 – 1209293
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1043_hemE_dna
AGTACCCGTCGCGAGCTTCTCGAATCGCCGTATCTGGCCGCGGTCAGTGGACGCAAACCCTGCCGGGTTCCGGTGTGGTTTATGCGGCAAGCCGGCCGCTCGTTGCCTGAATACCGGGCGCTGCGCGAGCGATACAGCATGTTGGCGGCGTGCTTCGAGCCCGAAGTGGCCTGTGAAATCACTCTGCAGCCGTTACGTCGTTACGACGTTGATGCCGCGATCTTGTTCTCAGACATCGTGGTGCCGCTGTGCGCGGCAGGAATCGATCTGGATATTGTGCCAGATGTCGGTCCAGTGATCGGGGACCCGGTCCGGACTGCCACCGATATCCACGCTATGAAACCCCTTGAACCACAAGCGATTCAGCCTATTTTTCAGGCTATTTCGTTGCTGGTCGCAGCACTGGGTGATGTTCCGCTGATCGGTTTCGCCGGTGCGCCGTTTACGCTGGCGTCCTACCTGGTCGAAGGCGGTCCTAGTCGTAATCATCCCCGCACTAAGGCCATGATGCTGGCCGAACCTGCGAGCTGGCATACGCTGATGGATAAGCTGACCGATCTGACTCTTGGATTTTTGCTTGGTCAAATCGACGCCGGAGTTGATGCCATCCAGGTATTCGACTCGTGGGCGGGAACGCTGTCCCTGTCCGATTACCGCCAGTACGTGTTGCCACATAGCGCCCGGATTTTTGCCACGGTGGCCGAACACGGGGTGCCGATGACGCACTTCGGGGTTGGCACCGCCGACCTGCTGGGTGCGATGTCAGCGGCTGTGCGGTCAGGCGAAAAGCCTGGGCACCAGGCCGTCGTCGGCGTGGATTGGCGAACCTCGTTGACCGATGCTGCTGCCCGAGTGGAACCCTGTACCGCGCTGCAGGGCAACCTCGACCCGGTGGTGCTGTTAGCGGGCTGGCCGGCTGTCGAACGTGTCGCACGGACTGTCGTCGACGACGGGCGCCGTGCCGTCGTGGCCGGCGCGGCTGGCCACGTTTTCAATCTCGGCCATGGAGTGTTGCCGGAGACCGATCCCGGCGTGCTGAGCGAATTAGTATCGTTCATCCACTCGCTATGACAT

Protein Sequence 

>ML1043_HemE_protein
STRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACEITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDPVRTATDIHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGPSRNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQYVLPHSARIFATVAEHGVPMTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVERVARTVVDDGRRAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL_H

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HemE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

16 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HemE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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