htrA
mL1078
PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1240775 – 1242376
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1078_htrA_dna
AATACTAGGGTGGACACCGACAACGCGGTAATCCGATATCGGCGCCGTAACAGGCCCTGTCTCGAGCGCTCAGAAGAGGATAATGTGACCTCCGACCAAGGCACCAACAACGACCAAAATCCCGGCCATCACCTGGCGACGCGCCCCGTCGCCAGGCCTCCTGTCGACGCCGCGTCCCGTGAGGCGTTCGGCCGCCCCTGTGGGTTTTCGGGATCCTTTGTAGCTGAATATGTGCGCCCACAGAAATATCGAGACCGCAGCGAATTCAGGCCTGATGATCAACCAGCCGACCCCGTCCTTGCCGAGGCATTCAGCCGGCCATTCGGGAGCGTCGATTCGCTGCAGCGCCATCCTATCGATGCGGGTGCGCTGGCTGCTGAGAAAGATGCCACTCAGCTGGACGAACCCGATGATCCGTGGCGAGACCCTGCGGCTGCGGCTACTCTGGCGAGTCCTGCAGTGGCTTCACCGGTGCCGCACACTGAGTTGGGTCAATGCGGCAAACTCGGTGTGCGCGACGTGCTATTTGGCGGCAGAGTGTCCTACCTTGCCCTGGTCATCTTGGTCTTTATTGCTTTGGCGCTGGGTGCTATCGGCGGTGTGATCGGTCGTAAGACGGCTGAAATCGTCGACGCGTTCACCACGTCGAAAGTGACGTTGGCAACCACTAACAATACTGAAGAGCCGGCCGGTCGTTTCGCCAAGGTGGCGGCGGCGGTAGCTGACTCCGTGGTGACGATTGAGTCGAAGAGTGACCAGGAGGAAATGCAGGGCTCCGGTGTCATCATCGATGGCCGCGGCTACATCGTCACTAACAACCACGTGATTTCCGAAGCGGCCAACAAGCCCAGCCAGTTCAAGACGACCGTGGTGTTCAACGACGGCAAGGACGTGCCCGCCAATCTGGTGGGCCGCGACCCCAAGACCGACCTGGCCGTACTCAAGGTCGATAACGTCGACAACCTGACGGTGGCGCGGCTTGGTGATTCCGGCAAGGTGCGGGTTGGTGATGAGGTTATCGCAGCGGGTGCGCCGCTTGGGCTGCGCAGCACGGTGACCCACGGCATCGTTAGCGCACTGCACCGCCCTGTCCCGTTATCGGGAGAGGGATCTGACACGGACACCGTCATCGATGCCATCCAGACCGACGCATCAATCAACCATGGCAACTCTGGTGGGCCGCTGATCGACATGGATTCCCAGGTGATCGGCATCAATACTGCCGGCAAGTCACTGTCGGACAGCGCCAGTGGGCTGAGCTTTGCGATCCCGGTCGACGAGATGAAATCGGTTGTGCAAACACTGATCAAGGACGGCAAGATCGTGCACCCGACGTTGGGGGTCAGCACCCGGTCGGTGAGCAACGCTATCGCGTCCGGCGCCCAGGTGGCCAATGTGAAGGCAGGAAGCCCCGCGCAAAAGGGCGGAATCCTGGAAAACGACGTCATAGTCAAGGTCGGCAACCGGAAAGTCGCCGACGCCGATGAGTTCATCGTTGCCGTGCGGCAGCTGACCATTGGACAGGACGCCTCAGTAGAGGTGGTCCGCGACGGTCGGCACGTCACGCTGACGGTGAAATCCGACCCCGATAGTAGCTAGTGT

Protein Sequence 

>ML1078_HtrA_protein
NTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAASREAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVPHTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAAVADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDSQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS_C

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HtrA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

4 show intermediate predicted evidence for PPIs

42 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HtrA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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