ileS
mL1195
isoleucyl-tRNA synthetase IleS
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1410788 – 1413967
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1195_ileS_dna
ACTAACAGCGCCTACCCGCGCACTGATCTGGGCGCCGACCAGCGCGGCGGGTCCCCAAATTTTCCTGCGCTGGAAGCCCAGGTCCTCGATTATTGGTCCAACGACGATACTTTTCGGGCCAGCATTGCCCGTTGTGACGACGCCCCCGAGTACGTGTTCTATGACGGACCTCCCTTCGCTAATGGCCTGCCACATTATGGGCATCTGCTCACCGGCTATGTGAAGGACATCGTTCCGCGTTACCGCACCATGTGTGGCTATAAAGTAGAGCGCCGCTTTGGTTGGGACACGCACGGGCTGCCTGCTGAACTCGAAGTCGAGCGGCAGCTGGGTATCACCGACAAATCCCAGATCGACGCCATGGGAATTGCCGCGTTCAACGAAGCATGTCGCAAATCGGTGTTGCGCTACACGGAAGAATGGCAGGCGTATGTAACCCGCCAGGCACGCTGGGTCGACTTCGATAACGATTACAAGACACTCGATCTGTCTTACATGGAGTCTGTGATCTGGGCGTTTAAACAGCTGTGGGACAAGGGTTTGGCTTACGAGAGCTATCGGGTGTTGCCGTACTGCTGGCGCGACGAAACCCCGCTATCCAACCACGAACTGCGGATGGACGACGACGTCTATCAAAGCCGCCAGGATCCGGCGGTCACGCTGGGCTTCAAGGTGCTGGGGGGTGACGATGAGGACCTAGTTGGTGCTTATCTTTTGGTGTGGACGACGACGCCCTGGACTTTACCGTCGAACCTGGCCGTTGCCGTCCATCCGGATGTAACCTATGTCGATGTCAGGGCAGGCGATCGCCGTTTCGTTTTGGCACAGGCGCGTCTGACCGCCTATGCTCGAGAGCTAGGCGACGAACCTGAGGTGCTTGCCACCTATCGTGGCGCCGATCTGCTGGGCAGGCACTATCTGCCGCCGTTCCAGTATTTCTACGAGTCTGCTAGAAATGCATTTCAGGTGCTCCCAGGAGACTTCGTGACTACTGATGACGGCACTGGTATCGTCCATATCGCGCCTGCCTACGGCGAAGATGATATGGCGACCGCCGATAAGGTTGGCATCGTTCCGGTCACGCCGGTTGACTCTAACGGTTGTTTTGACGCCACCGTGCCCGATTACCAGGGGCAACACGTCTTTGAGGCCAACGCCCAGATCATCCGCGATCTGAAGAACCAGAGTGGCTCGGCGGCGGTGAACGGCGCGGTGTTGCTTCGTCACGAAACCTATGAGCACCCATACCCGCATTGCTGGCGATGTCGCAATCCGCTGATCTACCGTGCGGTGTCGTCATGGTTTGTCGCTGTGACGGAATTCCGGGACCGCATGGTGGAACTGAACCAACAGATCACCTGGTATCCTGAGCACGTCAAGGACGGTCAGTTTGGTAAGTGGTTGCAGGGTGCCCGCGATTGGTCTATCTCACGAAACCGCTACTGGGGCACCCCAATCCCAGTGTGGAAATCGGATGATCCCGATTACCCAAGAATCGATGTATACGGCAGCTTGGATGAGCTGGAGCGCGATTTCGGGGTGCGTCCCACGAATCTACATCGCCCCTACATCGACGAGCTCACCCGACCCAACCCTGACGATCCCACCGGCCTTAGCACCATGCGACGGATCCCGGATGTTTTTGATGTGTGGTTCGACTCGGGTTCTATGCCATATGCTCAGGTGCACTACCCGTTTGAAAACGATGACTGGTTCGACGGGTTCGATTCCGCTGATTCTGACAAGCAGGTCGACGCGCACTATCCTGGCGATTTCATCGTCGAGTACATCGGTCAGGCCCGCGGTTGGTTCTACACGCTACATGTGCTGGCCACTGCACTCTTTGATCGTCCGGCATTCAAAACCTGTATAGCGCATGGGGTTGTGCTGGGGTCTAACGGTCAGAAGATGAGCAAGTCGTTGCGCAACTACCCAGACGTTACTGAGATATTTGACCGCGACGGTTCCGATGCCATGCGGTGGTTTTTGATGGCCTCGCCGATCCTGCGTGGCGGCAACCTCATCATAACTGAACCCGGAATCCGCGAAGGCATGCGGCAGGTGCTGCTGCCGTTGTGGAACGCTTACAGTTTTTTGGCCCTTTACGCACCCAAAATCGGTACCTGGCATACGGATGTGTCGCATGTGTTGGACCGTTATATTCTGGCGAAGCTGGCGGTACTGCGTGATGATCTCAGTCAGGCGATGGAGGTCTGTGATATCTCTGGGGCCTGCGAACAGCTTCGCCAATTCACCGAGCCGCTAACGAATTGGTATTTGCGACGGTCGCGTGCGCGGTTCTGGGACGAAGATGTTGATGCTATCGATACCCTGCACACCGTGCTGGAAGTGACCGCCAGGTTGGCTGCACCACTTCTCCCGTTGATCACCGAGATTATTTGGCGCAGTGTCACTGGTGGGCGTTCGGTACACCTGACCGATTGGCCGCAAGCCAACCAGCTACCCGCCGACCCTGACCTGGTTGCTGTGATGGATCAGGTCCGACAAGTGTGTTCCGCAGCGTCATCGCTGCGCAAGGCTAAGAAGCTTCGGGTACGCCTTCCTCTACCGAAACTCGTTGTAGCAGTGTATAATTCACAGAGACTAAAGCCCTACATTGACTTAATCGGCGATGAGCTTAACGTCAAGCAGATAGAACTGACCGATGCTATTGACACCTACGGCCGATTTGAGTTCACCGTCAACGCTCGAGTGGCCGGGCCGCGATTGGGAAGGGATGTGCAGGCTGCCATCAAGGTGGTAAAGGCGGGAGAAGGGGTCGCCAACCCGGATGGCACCCTGACCGCCGGGCCCGTTGTGCTGCAACCTGACGAGTACAGTTCGCGGTTGGTGGCCGCTAACCCGGAATTTACCGCGGAGCTGCCCGACGGGTCCGGTCTTGTTGTGTTGGACGATACGGTGACTCCCGAACTGGAGGCCGAGGGCTGGGCCAAGGATCGGATCCGCGAACTACAGGAGTTGCGTAAGTTGATCGGGCTGGATGTTTCCGATCGTATCCGGGTGTTGATGTCGGTGCCGGCCGAGCGGGCTGACTGGGCGCGCGTCCATCGCGACTTCATCGCTAGGGAAATCCTGGCCACCAGCTTCGAGTTTGGCGAGCCGGCTGATTCGGTGGCTATCGGAGATGGCGTCCGAGTCAGCCTTTTAAAGGTCTAAGTC

Protein Sequence 

>ML1195_IleS_protein
TNSAYPRTDLGADQRGGSPNFPALEAQVLDYWSNDDTFRASIARCDDAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMCGYKVERRFGWDTHGLPAELEVERQLGITDKSQIDAMGIAAFNEACRKSVLRYTEEWQAYVTRQARWVDFDNDYKTLDLSYMESVIWAFKQLWDKGLAYESYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTLGFKVLGGDDEDLVGAYLLVWTTTPWTLPSNLAVAVHPDVTYVDVRAGDRRFVLAQARLTAYARELGDEPEVLATYRGADLLGRHYLPPFQYFYESARNAFQVLPGDFVTTDDGTGIVHIAPAYGEDDMATADKVGIVPVTPVDSNGCFDATVPDYQGQHVFEANAQIIRDLKNQSGSAAVNGAVLLRHETYEHPYPHCWRCRNPLIYRAVSSWFVAVTEFRDRMVELNQQITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPDYPRIDVYGSLDELERDFGVRPTNLHRPYIDELTRPNPDDPTGLSTMRRIPDVFDVWFDSGSMPYAQVHYPFENDDWFDGFDSADSDKQVDAHYPGDFIVEYIGQARGWFYTLHVLATALFDRPAFKTCIAHGVVLGSNGQKMSKSLRNYPDVTEIFDRDGSDAMRWFLMASPILRGGNLIITEPGIREGMRQVLLPLWNAYSFLALYAPKIGTWHTDVSHVLDRYILAKLAVLRDDLSQAMEVCDISGACEQLRQFTEPLTNWYLRRSRARFWDEDVDAIDTLHTVLEVTARLAAPLLPLITEIIWRSVTGGRSVHLTDWPQANQLPADPDLVAVMDQVRQVCSAASSLRKAKKLRVRLPLPKLVVAVYNSQRLKPYIDLIGDELNVKQIELTDAIDTYGRFEFTVNARVAGPRLGRDVQAAIKVVKAGEGVANPDGTLTAGPVVLQPDEYSSRLVAANPEFTAELPDGSGLVVLDDTVTPELEAEGWAKDRIRELQELRKLIGLDVSDRIRVLMSVPAERADWARVHRDFIAREILATSFEFGEPADSVAIGDGVRVSLLKV_V

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding IleS with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

67 show weak predicted evidence for PPIs

View all pooled AlphaFold results for IleS

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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