plsC
mL1245
POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE) (LPAAT)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1484292 – 1486031
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1245_plsC_dna
AGTGCCTTCGACGAGAACGGGACGCCCAAGTCAGGGCCGGAAGTGCGCTTGCCTGGTTCGGTCGCCGAGATCCTTGCCAGTCCTGCTGGTCCCCAGGTAGGGGCGTTTTTCGACTTGGATGGGACGCTGGTTGCCGGCTTTACCGCAGTCATCCTTACGCACGAGCGTCTGCGACGCTGTGATATGGGTGTGGGAGAATTGCTTTCAATGATTCAGGCTGGTCTGAACCATACACTCGGGCGCATCGAGTTCGAGGACCTCATCGGTAAGGTTTCCTCGGCGTTGCGCGGACGGTTATTGACTGACTTGGAGGAGATCGGCGAGCGGCTGTTTGCCCAGCGCATCGAGTCTCGGATCTACCCTGAAATGCGTAAGCTGGTGCAGGCTCACGTGGCTCGCGGTCACACCGTGGTGCTCAGCTCGTCGGCCCTGACGATTCAAGTGGGGCCGGTCGCACGTTTTCTGGGTATTGCCCACATGCTCACCAACAAGTTTGAGATCAACGAAGACGGAATGCTCACTGGTGGCGTGGTTAAACCGATCTTGTGGGGTCCGGGCAAAGCCGCTGCGGTACAACGATTTGCTGCTGAGCATGACATCGACCTCAAGGACAGCTACTTCTACGCTGATGGTGACGAGGACGTCGCGCTGATGTATCTAGTTGGCAATCCACGGCCGACTAACCCTGAAGGAAAAATGGCTGCCGTCGCCAAACGCCGTGGCTGGCCGATCTTGAAATTCAACAGCCGTGGCGGCGTTGGTATCGGAGCGCAGTTGCGAACACTGGTCGGCCTGAGTTCAGTGCTACCACTCGTGGCCGGCGCGGTGGGAATCGGTGTGTTGACTGGTAGCCGTCGGCGGGGTGCCAACTTCTTCACCTCTGTCTTTCCCCCGTTGGTGCTCGCGGCCGCGGGGGTGCATCTCAATGTGATCGGGAACGAGAACCTGACCATGCAGCGTCCCGCCGTGTTCATCTATAACCATCGCAATCAGATTGACCCGCTCATCGCCGGTGCGCTAGTGCGTGGCAATTGGATTGCTGTGGCCAAGAAAGAATTGGCAAAGAATCCGATCATCCGCGCGCTCGGCAAATTAACCGACGGTGTGTTTATTGACCGGGACGATCCGGTCGGCGCGGTAGAGACGTTGCACGCGGTCGAAGACCGGGCCAGGAAGGGACTCTCGATTCTGATGGCCCCAGAAGGTACCCGATTAGATACCACAGAAGTCGGGCCGTTCAAGAAGGGGCCTTTCCGCATCGCGATGGCGGTCGGGATCCCGATTGTTCCGATTGTGTTCCGCAATGCGGAGATCGTCGCCGCTCGAAACTCCAATACGATTAATCCGGGCATGGTCGATGTCGCGGTTTTGCCGGCGATTCCGGTTGATGACTGGACTCTTGATGCGTTATCGGAGCGCATTGCCGAGGTGCGTCAGCTGTATCTGGACATTCTGGCTGACTGGCCGGTCGACGAGCTGCCCAAGGCTGCTCTGTACACCCGGGCAACAAAGGCGACGGTGAAAAAGGCGGAGCCAAAAAAGGGCGGTCGCACTTCGGCCGCCAAGACCACCGCTAAGAAGACAGCGACCAAGGCCACGGCAGCTAAGACTGCTAACACAGCTGTTACCAAAAGCATGTTGACGCCCCCCACGAGGATATCGGACAAAGAGAACCCGAAAGTACCTAAGGTCGTTTCCCAAGACCTCGTCGTGAAACAGCCCAGAGAGCGGTCGTGACTG

Protein Sequence 

>ML1245_PlsC_protein
SAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVAGFTAVILTHERLRRCDMGVGELLSMIQAGLNHTLGRIEFEDLIGKVSSALRGRLLTDLEEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAHMLTNKFEINEDGMLTGGVVKPILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSVFPPLVLAAAGVHLNVIGNENLTMQRPAVFIYNHRNQIDPLIAGALVRGNWIAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILMAPEGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQLYLDILADWPVDELPKAALYTRATKATVKKAEPKKGGRTSAAKTTAKKTATKATAAKTANTAVTKSMLTPPTRISDKENPKVPKVVSQDLVVKQPRERS_L

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PlsC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

4 show intermediate predicted evidence for PPIs

26 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PlsC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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