hisH
mL1260
Imidazole glycerol phosphate synthase subunit HisH (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH) (ImGP synthase subunit hisH)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1505405 – 1506025
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1260_hisH_dna
AGAAGTAAATCGGTTGTAGTTCTGGATTACGGTTCGGGTAATTTGTGGTCGGTGCAGCGCGCGCTGCAGCGGGTTGGTGCCGCGGTCGAAGTTACGGCTGACTCAGCTGCAGGCGCCGCCGCTGACGGGTTGCTGGTGCCCGGTGTCGGCGCGTTCGAGGCGTGCATGGCAGGTCTGCGGAAAATCGCGGGTGAACGGACCATCGCCGAGCGGATCGTCGCGGGACGGCCGGTATTAGGGGTCTGTGTCGGCATGCAGATTTTGTTCGCCCGCGGTGTCGAATTCGGTGTGGAAACAACAGGCTGTAGGCAGTGGCCGGGCGTTGTGACCCGGCTCGACGCCCCGGTGGTTCCCCATATGGGCTGGAACGTAGTCGATTCCGCTTCTGGAAGTGCGTTGTTCAAGGGCCTAGATGCTGGAGTGCGGTTCTATTTCGTGCATTCTTATGCCGCGCAGCGTTGGGAAGGCTCATCCAAGGCGCTGCTGACATGGGCAACTCACCAAGTACCGTTTTTGGCCGCGGTGGAAGAAGGACCACTGGTTGCCACCCAGTTCCATCCGGAGAAGAGTGGGGACGCTGGAGCAACCTTGCTGAGCAATTGGCTTGGGGAACTTTAAAGG

Protein Sequence 

>ML1260_HisH_protein
RSKSVVVLDYGSGNLWSVQRALQRVGAAVEVTADSAAGAAADGLLVPGVGAFEACMAGLRKIAGERTIAERIVAGRPVLGVCVGMQILFARGVEFGVETTGCRQWPGVVTRLDAPVVPHMGWNVVDSASGSALFKGLDAGVRFYFVHSYAAQRWEGSSKALLTWATHQVPFLAAVEEGPLVATQFHPEKSGDAGATLLSNWLGEL_R

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HisH with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

53 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HisH

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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