hisA
mL1261
PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDE ISOMERASE HISA (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1506035 – 1506772
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1261_hisA_dna
ATGTCGCTGATACTTTTACCGGCTGTCGACGTGGTCGAGGGGCGCGCCGTGCGCCTGGTTCAAGGAAAGGCCGGTAGCGAAAACGATTACGGTTCAGCATTGGACGCCGCGTTGTGCTGGCAACGCGACGGCGCCGACTGGATTCACCTAGTGGATCTGGACGCAGCGTTTGGTCGCGGTTCCAACCGCGAACTGCTTTCTGAGATGGTGGGCAAGCTTGATGTGCAGGTCGAGCTATCCGGAGGTATTCGTGACGACGACTCTTTGAATGCTGCGCTAGCTACCGGCTGTGCACGGGTCAACCTAGGTACGGCCGCATGTGAGAACCCGCACTGGTGCGCACAGGTGATTGCCGAGCACGGTGACAAGATCGCCGTCGGTTTGGACGTCCAGATCGTCGACGGCCAGCATCGGCTGCGTGGACGCGGCTGGGAAACCGACGGAGGAGACCTGTGGGATGTGTTAGAAAATCTTGATAGACAAGGATGTTCACGGTTCATTGTTACCGATGTCACTAAGGACGGTACGTTGGACGGTCCCAACCTTGACCTGCTGGCAAGTGTCTCCGATCGCACCAACGTCCCGGTGATCGCGTCCGGTGGCGTTTCCAGTCTGGATGACTTGCGTGCTATCGCTAAATTCACCGAGCGCGGGATCGAGGGTGCTATTGTGGGCAAAGCCCTCTATGCCGAACGGTTCACCTTGCCGCAGGCACTGGCCGTGGTGCGGATGTAGCCC

Protein Sequence 

>ML1261_HisA_protein
MSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVELSGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAEHGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLDRQGCSRFIVTDVTKDGTLDGPNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQALAVVRM_P

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HisA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

13 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HisA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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