trpE
mL1269
Probable anthranilate synthase component I TrpE (GLUTAMINE AMIDOTRANSFERASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1512142 – 1513731
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1269_trpE_dna
CACGCCCACCTCGCCGCCACCACGTCACGTGAGGACTTTCGCCAGCTAGCTGTCGATCATCGGGTGGTTCCAGTGACCCGCAAAGTCTTGGCCGATAGCGAAACGCCGCTATCGGCATACCGGAAGCTCGCCGCCAATCGTCCGAGCACCTTCCTGCTAGAGTCGGCCGAGAACGGCAGATCCTGGTCGCAGTGGTCGTTCATTGGCGTGGGTGCCCCATCGGCTTTGACAATTCGTGACGGCGAAGCGGTGTGGCTGGGCACTGTACCGCAGGACGCGCCCACTGGCGGTGACCCCCTGCATGTCCTGCAGGCCACGCTCGAGCTACTTGCCACCGCGGCAATGCCCGGGTTGCCACCGCTATCGAGTGGTATGGTGGGCTTCTTCGCCTACGACATGGTGCGGCGCCTGGAGCGCCTGCCTGAACTGGCCTTAAATGATTTGCAGTTGCCCGATATGCTGCTGCTGTTGGCCACCGATGTAGCGGCCGTTGACCACCACGAGGGCACGATCACCCTGATTGCCAACGCTGTGAACTGGAACGGTACCGATGAGCGGGTAGATCAGGCCTACGACGATGCGATCGCGCGCTTGGACGTAATGACCGCAGCACTGGGCCAGCCGCTGCCATCGACCATTGCCACGTTCAGCCGGCCCGACCCTCGGCGCCGAGCGCAATGCACCATCGAGGAATACGGTGCGATCGTCGACCACCTCGTCGACCAGATCGCGGCCGGTGAGGCCTTTCAAGTGGTGCCCTCGCAGCGCTTCGAGGTGGATACCGATGTCGATCCGATCGATGTCTATCGCATGCTGCGGGTCACCAACCCTAGCCCTTACATGTATCTGCTGCATGTGCCTAATAGCGATGGAGCAACTGGCTTTTCGATCGTTGGATCCAGCCCGGAGGCGTTGGTGACCGTCAAGGACGGTCGGGTGACGACGCATCCGATCGCTGGAACTCGCTGGCGAGGCCAGACCGAAGAAGAGGATCAGCTACTGGAAAAAGAGTTGCTCGCCGACGAGAAGGAACGAGCAGAGCACTTAATGCTTGTCGATCTCGGTCGCAACGACCTTGGTCGGGTCTGTACGCCAGGCACCGTACGTGTCGAGGATTACAGCCACGTTGAACGTTACAGTCACGTAATGCACATGGTGTCTACGGTGACCGGGCTGCTCGGTGAAGGCCGCACCGCCCTGGACGCGGTGACCGCCTGCTTCCCTGCCGGCACGCTGTCGGGTGCCCCGAAGGTGCGGTCCATGGAGCTAATCGAGGAAGTGGAGAAGACGCGCCGCGGCCTTTATGGTGGCGTGGTCGGTTACCTCGACTTCGCTGGTAACGCTGACTTCGCGATAGCAATCCGTACAGCGCTGATGCGTGACGGCATCGCGTATGTCCAAGCCGGCGGTGGGGTAGTGGCCGACTCCAACGGGCCCTACGAATACATCGAGGCGAGTAACAAGGCTCGAGCGGTGTTGAACGCGATCGCCGCCGCCGAGACGTTGACCTCTTTGGACTTCGGTGTTGCCCTCGCCCCTGGCCGCGTGGCGGCCAGGGGCGAGGCGGGCAATCAAGGGAGGCTGTGATGG

Protein Sequence 

>ML1269_TrpE_protein
HAHLAATTSREDFRQLAVDHRVVPVTRKVLADSETPLSAYRKLAANRPSTFLLESAENGRSWSQWSFIGVGAPSALTIRDGEAVWLGTVPQDAPTGGDPLHVLQATLELLATAAMPGLPPLSSGMVGFFAYDMVRRLERLPELALNDLQLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDQAYDDAIARLDVMTAALGQPLPSTIATFSRPDPRRRAQCTIEEYGAIVDHLVDQIAAGEAFQVVPSQRFEVDTDVDPIDVYRMLRVTNPSPYMYLLHVPNSDGATGFSIVGSSPEALVTVKDGRVTTHPIAGTRWRGQTEEEDQLLEKELLADEKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHVERYSHVMHMVSTVTGLLGEGRTALDAVTACFPAGTLSGAPKVRSMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRDGIAYVQAGGGVVADSNGPYEYIEASNKARAVLNAIAAAETLTSLDFGVALAPGRVAARGEAGNQGRL_W

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding TrpE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

6 show intermediate predicted evidence for PPIs

53 show weak predicted evidence for PPIs

View all pooled AlphaFold results for TrpE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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