trpB
mL1272
Probable tryptophan synthase%2C beta subunit TrpB
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1515385 – 1516638
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1272_trpB_dna
ATGCCGAATCTATCCTGTTTTAGCGTGGCCATCTCCGAACCCACTTGCCACGACCCCGATTCGGGTGGGCATTTTGGTGGCCCCGATGGTTATGGTGGTCGCTACGTCCCCGAAGCGCTGATGGCGGTGATCGAGGAGGTCACCGCCGCTTACGAGAAGGAACGCGTTAATCAGGACTTCCTGGACCTGCTGGACAAGTTGCAAGCAAACTACGCTGGCCGGCCGTCGCCGCTATATGAAGCTACTCGGCTTAGCGAATACGCTGGCTCGGTGCGCATCTTTCTCAAGCGGGAAGACTTGAACCACACTGGTTCTCACAAGATCAACAATGTCCTTGGTCAGACATTGCTGGCCCAGCGAATGGGCAAGACGCGAGTGATTGCTGAGACGGGTGCCGGTCAGCATGGAGTGGCCACAGCGACGGCGTGTGCGCTGTTCGGCCTGGATTGTGTGATCTACATGGGTGCCCTTGACACTGCTAGGCAGGCACTCAACGTGGCGCGGATGCGGTTGCTGGGTGCCGAGGTCGTATCGGTCGAGACTGGCTCGCGAACGCTCAAGGACGCCATCAACGACGCGTTCCGGGATTGGGTTACTAATGCAGATAACACTTACTACTGCTTCGGGACTGCTTCGGGACCGCATCCTTTTCCGACTATGGTGCGTGACTTACAGCGCGTCATCGGTCTCGAGACACGTCGGCAAATCCAGTATCAGGCGGGCAGGCTACCGGACGCGGTTACGGCGTGCATCGGCGGAGGGTCCAACGCTATCGGGATCTTCCACGCGTTCCTCGATGATCCGGGTGTACGGCTGGTCGGGTTCGAGGCAGCTGGCGATGGCGTCGAGACTGGCAGGCATGCAGCGACATTGACCGGCGGCTTGCCCGGAGCGTTCCAGGGAACGTTCTCCTACTTGCTGCAGGACGAGGACGGTCAGACCATCGAGTCCCATTCAATCGCAGCAGGTCTGGACTATCCGGGGGTTGGCCCCGAACACGCGTGGCTCAGGGAAACCGGACGCGCCGAATACCAGCCCATTACTGATTCTGAGGCGATAGAGGCGTTTCGTTTACTGTGTCGCACCGAAGGTATTTTACCGGCCCTCGAGTCCGCGCATGCTGTAGCCGGTGCCCTCAAGTTGGCTTCTGAAATAGGCAAGGGTGCGGTCATAGTGGTGAACCTTTCGGGTCGCGGCGATAAGGATATCGAGGCAGCTGCTAAGTGGTTCGGCCTGCTGGGTACCAGATGATGG

Protein Sequence 

>ML1272_TrpB_protein
MPNLSCFSVAISEPTCHDPDSGGHFGGPDGYGGRYVPEALMAVIEEVTAAYEKERVNQDFLDLLDKLQANYAGRPSPLYEATRLSEYAGSVRIFLKREDLNHTGSHKINNVLGQTLLAQRMGKTRVIAETGAGQHGVATATACALFGLDCVIYMGALDTARQALNVARMRLLGAEVVSVETGSRTLKDAINDAFRDWVTNADNTYYCFGTASGPHPFPTMVRDLQRVIGLETRRQIQYQAGRLPDAVTACIGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATLTGGLPGAFQGTFSYLLQDEDGQTIESHSIAAGLDYPGVGPEHAWLRETGRAEYQPITDSEAIEAFRLLCRTEGILPALESAHAVAGALKLASEIGKGAVIVVNLSGRGDKDIEAAAKWFGLLGTR_W

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding TrpB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

2 proteins show strong predicted evidence for PPIs

8 show intermediate predicted evidence for PPIs

46 show weak predicted evidence for PPIs

View all pooled AlphaFold results for TrpB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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