trpA
mL1273
Probable tryptophan synthase%2C alpha subunit TrpA
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1516635 – 1517447
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1273_trpA_dna
ATGGTTCTGGAACAGAGCGAAACAAGTAGGCTTGGGCCGGTTTTCGATTCGTGTCGTGCGGACAATCGCGCGGCATTGATTGGTTACTTGCCCACCGGTTACCCTGATGTGCCTACTTCGGTGGACGCGATGATAGAACTCGTCGAATCCGGCTGTGACATCATTGAAGTTGGCGTTCCTTATTCGGATCCCGGTATGGACGGTCCAACCATCGCGAGGGCCACCGAGGTTGCGCTTCGTGGAGGAGTACGAGTCCGCGATACTCTAGCCGCGGTCGAGGCGATCAGCCAAGCTGGCGGACGCGCCGTGGTGATGACGTACTGGAATCCTGTGTTGCGCTATGGGGTTTGTGCGTTTGCGCGGGATCTGGAGTCAGCTGGAGGACACGGTCTGGTCACTCCCGACCTTATTCCCGACGAAGCACGCCAATGGATCGCGGCATCCGAGAAGCATCGGTTGGATCGCATTTTTCTAGTGGCTCCATCATCGACGCCGCACCGGTTGGTGACCACGGTCGGGGCATCACGTGGATTTGTTTATGCGGTGTCTGTGATGGGTGTGACCGGGGCGCGTGACGCGGTGTCGCAGGTTGTGCCAGAACTGGTGGCCAGGGTGAAGGCAGTATCTGACATTGCGGTCGGGGTCGGCCTGGGGGTGCGATCACGAGAGCAGGCCGCGCAGATCGGCGGCTACGCCGACGGTGTCATTGTTGGTTCCGCGTTGGTGTCGGCGCTGGGTGACGGTTTGCCTCGATTGCGTGCTCTTGCCGAGGAACTCGCCGCCGGCGTGCGCCAAAGGACGTTCATGTGACGA

Protein Sequence 

>ML1273_TrpA_protein
MVLEQSETSRLGPVFDSCRADNRAALIGYLPTGYPDVPTSVDAMIELVESGCDIIEVGVPYSDPGMDGPTIARATEVALRGGVRVRDTLAAVEAISQAGGRAVVMTYWNPVLRYGVCAFARDLESAGGHGLVTPDLIPDEARQWIAASEKHRLDRIFLVAPSSTPHRLVTTVGASRGFVYAVSVMGVTGARDAVSQVVPELVARVKAVSDIAVGVGLGVRSREQAAQIGGYADGVIVGSALVSALGDGLPRLRALAEELAAGVRQRTFM_R

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding TrpA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

11 show intermediate predicted evidence for PPIs

60 show weak predicted evidence for PPIs

View all pooled AlphaFold results for TrpA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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