pyrD
mL1293c
Probable dihydroorotate dehydrogenase PyrD
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1543268 – 1544341
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1293c_pyrD_dna
AACTGTGATGTACCGGGTCGTACGCCGGCTGCTGTTCCTGACCCCACCCGAGCGGATACACACACTGGTTTTTGCCATGCTGCGTTGCGTAACCTCCATCGCTGTGCTGCGCCGGTTGCTGCGCTGGGTACTGGGACCGACGGATCCGGTGCTGGCCAGCACGGTTTTTGGGGTCCGCTTCCCCGGACCGCTGGGGCTGGCAGCGGGCTTCGACAAGGACGGCATGGGGCTGCTTGCCTGGGGTGCATTAGGGTTCGGTTATGCTGAAGTCGGAACCGTCACCGCGTACCCACAGCCCGGCAACCCGGCCCCGCGCATGTTCCGGCTGCCCGCCGACCGCGCTCTGCTGAACAGGATGGGGTTCAACAATAACGGCGCCGGAGCGCTGGCTATCCAGCTCGCCCACCACCGCCCCGAAGTGCCTATCGGGGTGAACATCAGCAAGACTAAGGCAACCCCGGCCTCCCATACTGTCGATGACTACCGGGCCAGCGCCCGGCTGGTCGGCCCGCTGGCCTCGTATCTGGTTGTCAATGTCAGCTCCCCGAATACCCCGGGGCTTCGCGACCTACAAGCAGTCGAGTCGCTTCGGGCCATCTTGTTGGGAGTCCTGGCTGAGACCTCAGTACCAGTGCTGGTCAAGATTGCACCCGATATCTCCGATTCCGAGATCGACGACATCACAGACCTAGCCGTCGAACTTAGGCTAGCAGGCATCGTGGCAACCAACACCACAGTATCGCGTGACTGCTTGGTGACACCGGGAATCGATGCGCTGGGGGCAGGTGGCATCTCGGGGCCGCCGGTGGCGCGCCGCGCTGTCGAGGTGTTGCGCCGGCTCTACGGACGGGTCGGTGACCGTCTGGTGCTCATCAGCGTGGGAGGCATCGAAACTGCCGACGACGCATGGGATCGCATCACAGCGGGCGCCTCGCTGCTCCAGGGCTATACCGGATTCATCTACGGCGGGGGATTCTGGCCCAAACACATTCACGACGGCATCGCACGCCGGCTTCATGACGGCGGGTTCGCCTCACTGCGCGACGCGGTCGGGTCGGCGACCGCCAAATCGGA

Protein Sequence 

>ML1293c_PyrD_protein
NCDVPGRTPAAVPDPTRADTHTGFCHAALRNLHRCAAPVAALGTGTDGSGAGQHGFWGPLPRTAGAGSGLRQGRHGAACLGCIRVRLC_SRNRHRVPTARQPGPAHVPAARRPRSAEQDGVQQ_RRRSAGYPARPPPPRSAYRGEHQQD_GNPGLPYCR_LPGQRPAGRPAGLVSGCQCQLPEYPGASRPTSSRVASGHLVGSPG_DLSTSAGQDCTRYLRFRDRRHHRPSRRT_ASRHRGNQHHSIA_LLGDTGNRCAGGRWHLGAAGGAPRCRGVAPALRTGR_PSGAHQRGRHRNCRRRMGSHHSGRLAAPGLYRIHLRRGILAQTHSRRHRTPAS_RRVRLTARRGRVGDRQIG

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PyrD with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

16 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PyrD

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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