metH
mL1307
Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase%2C vitamin-B12 dependent isozyme) (MS)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1556855 – 1560475
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1307_metH_dna
GTGTAACTGCCGCTAACCAACATCAGTACGACACCGATCTCCTCGAGACTTTGGCGCAGCGTGTGATGGTGGGTGACGGCGCAATGGGTACTCAGCTCCAGGACGCGGAACTTACGTTAGATGATTTCCGCGGCCTGGAGGGCTGCAACGAGATTCTCAACGAAACGCGTCCTGACGTGCTGGAAACCATCCACCGACGCTACTTCGAGGCAGGTGCGGACCTCGTCGAGACCAACACTTTCGGCTGCAACCTGTCCAACCTTGGTGACTACGACATCGCCGACAAGATCAGGGACTTGTCGCAGCGGGGCACCGTGATTGCGCGACGGGTCGCCGACGAGCTGACCACCCCCGACCACAAGCGATACGTGCTGGGGTCGATGGGACCAGGCACCAAGTTGCCCACCCTGGGCCACACCGAGTACCGGGTCGTTCGAGACGCCTACACCGAGTCGGCGTTAGGCATGCTGGACGGTGGCGCTGACGCCGTACTGGTTGAAACCTGTCAGGACTTGCTGCAGCTCAAGGCTGCGGTGCTGGGCTCGCGGCGCGCGATGACACAGGCCGGTCGGCACATTCCGGTCTTCGTCCACGTGACTGTCGAGACGACCGGAACGATGCTGCTGGGAAGTGAGATCGGCGCTGCACTGGCTGCCGTCGAGCCGCTCGGTGTCGACATGATCGGTTTGAACTGCGCAACGGGCCCCGCTGAGATGAGTGAGCATCTGCGGCACTTGTCCAAGCATGCCCGCATCCCGGTGTCGGTGATGCCCAACGCCGGGCTGCCGGTGCTGGGTGCCAAGGGAGCTGAATACCCGCTGCAGCCCGACGAATTGGCCGAAGCTTTGGCTGGGTTCATCGCTGAATTTGGTCTTTCGTTGGTAGGTGGCTGCTGTGGTACCACCCCGGACCACATCCGGGAAGTGGCCGCAGCGGTAGCCAGATGCAACGACGGGACAGTGCCACGCGGTGAGCGTCATGTGACCTATGAGCCGTCGGTATCGTCGCTGTATACAGCCATTCCATTCGCCCAAAAACCCTCGGTTCTGATGATCGGTGAGCGTACGAATGCCAACGGCTCCAAGGTTTTTCGTGAGGCAATGATCGCCGAGGACTATCAAAAGTGTCTAGATATCGCCAAGGACCAAACCCGTGGCGGCGCACACCTGCTGGATCTGTGTGTCGATTACGTCGGCCGCAACGGTGTGGCCGACATGAAGGCGTTGGCCGGTCGGCTTGCAACGGTGTCGACATTGCCGATCATGCTGGACTCTACCGAAATACCGGTGCTGCAGGCAGGTTTGGAGCACCTGGGCGGGCGCTGCGTGATCAATTCCGTCAACTACGAGGACGGTGACGGTCCCGAGTCACGGTTTGTCAAGACCATGGAGCTGGTCGCCGAGCACGGAGCGGCGGTGGTTGCGCTGACCATCGACGAACAGGGTCAGGCCCGCACCGTTGAGAAGAAGGTCGAAGTCGCGGAGCGGCTTATCAATGACATTACGAGTAACTGGGGCGTTGATAAATCGGCGATTCTCATCGATTGCTTGACTTTTACTATTGCCACTGGCCAGGAGGAGTCACGCAAAGACGGCATTGAGACCATCGACGCGATTCGTGAGCTGAAGAAGCGGCACCCAGCGGTGCAGACTACGCTGGGGTTGTCCAACATCTCCTTCGGTCTCAATCCTTCTGCACGCCAAGTTCTTAACTCTGTTTTTCTACATGAATGTCAGGAAGCAGGACTGGATTCGGCGATTGTGCACGCTTCAAAGATATTGCCCATCAACCGGATACCCGAAGAACAGCGCCAGGCTGCGCTGGATCTAGTGTATGACCGCCGTCGCGAAGGCTACGACCCATTGCAGAAGCTGATGTGGTTATTCAAAGGTGTGTCGTCGCCATCGTCGAAGGAAACACGGGAGGCAGAACTCGCTAAGCTGCCGTTGTTCGACCGGTTAGCACAGCGGATCGTCGACGGCGAGCGCAACGGGTTAGATGTTGATCTCGACGAGGCAATGACCCAGAAACCGCCGTTGGCGATCATCAACGAGAACCTGCTGGACGGCATGAAGACAGTCGGTGAATTGTTCGGCTCTGGGCAGATGCAGCTGCCTTTCGTGTTGCAGTCGGCCGAGGTTATGAAAGCAGCGGTGGCTTATCTAGAACCGCACATGGAGAAATCCGACTGTGACTTCGGTAAGGGGTTAGCCAAAGGACGGATTGTGCTGGCTACCGTCAAAGGAGATGTGCACGATATTGGCAAAAACCTCGTCGATATCATTCTGAGCAACAACGGCTACGAAGTGGTAAACCTCGGCATCAAGCAGCCGATTACCAACATTCTCGAGGTGGCCGAGGACAAAAGCGCCGACGTAGTCGGGATGTCGGGCTTGCTGGTGAAATCGACTGTGATCATGAAGGAAAACCTCGAGGAGATGAACACTCGCGGAGTCGCTGAGAAATTCCCAGTGCTGCTCGGCGGCGCGGCGTTGACCCGCAGCTATGTGGAAAACGACCTGGCCGAAGTCTATGAGGGCGAAGTGCATTACGCACGAGACGCTTTCGAGGGTTTGAAGTTGATGGACACCATTATGAGCGCCAAGCGCGGCGAGGCGCTTGCGCCGGGGAGCCCGGAGTCCTTAGCTGCAGAAGCAGACCGCAATAAGGAAACTGAGCGCAAGGCACGTCATGAGCGGTCCAAACGCATTGCAGTGCAGCGTAAGGCTGCCGAAGAGCCAGTTGAGGTTCCCGAACGCTCCGATGTTCCGAGTGATGTCGAGGTTCCGGCGCCGCCGTTCTGGGGTTCGCGGATCATCAAGGGTCTGGCGGTGGCCGACTATACCGGGTTCCTCGACGAGCGCGCGTTGTTCTTGGGTCAGTGGGGATTACGTGGTGTGCGCGGCGGTGCGGGGCCCTCGTACGAGGATTTGGTGCAGACCGAGGGCCGGCCGCGGTTGCGCTACTGGCTAGACCGATTGTCCACCTACGGCGTCTTGGCGTACGCCGCCGTGGTGTACGGTTACTTCCCGGCGGTGTCCGAAGACAACGATATTGTCGTGCTCGCTGAGCCGAGACCGGACGCCGAGCAGCGGTACCGGTTCACCTTCCCGCGTCAGCAACGCGGTCGGTTCCTGTGCATTGCCGATTTTATTCGATCCCGGGATCTGGCGACCGAGCGGAGTGAGGTGGATGTTTTGCCGTTCCAGCTGGTGACCATGGGTCAACCCATTGCTGACTTCGTTGGCGAGTTGTTCGTGTCCAATTCCTATCGTGATTATCTTGAAGTGCATGGCATCGGTGTGCAGCTAACCGAGGCGCTGGCCGAATACTGGCACCGGCGCATTCGTGAAGAGCTGAAATTCTCCGGAAACCGGACGATGTCGGCTGACGATCCCGAGGCCGTCGAGGACTATTTCAAGCTCGGCTACCGAGGTGCCCGCTTCGCGTTCGGGTATGGAGCATGCCCGGACCTGGAGGACCGGATCAAGATGATGGAGCTGCTTCAACCCGAACGCATCGGTGTAACGATATCTGAAGAGTTGCAGTTACATCCCGAGCAATCGACTGATGCGTTCGTGCTGCACCATCCGGCGGCTAAGTACTTCAACGTCTGAGGGC

Protein Sequence 

>ML1307_MetH_protein
V_LPLTNISTTPISSRLWRSV_WWVTAQWVLSSRTRNLR_MISAAWRAATRFSTKRVLTCWKPSTDATSRQVRTSSRPTLSAATCPTLVTTTSPTRSGTCRSGAP_LRDGSPTS_PPPTTSDTCWGRWDQAPSCPPWATPSTGSFETPTPSRR_ACWTVALTPYWLKPVRTCCSSRLRCWARGAR_HRPVGTFRSSST_LSRRPERCCWEVRSALHWLPSSRSVST_SV_TAQRAPLR_VSICGTCPSMPASRCR_CPTPGCRCWVPRELNTRCSPTNWPKLWLGSSLNLVFRW_VAAVVPPRTTSGKWPQR_PDATTGQCHAVSVM_PMSRRYRRCIQPFHSPKNPRF__SVSVRMPTAPRFFVRQ_SPRTIKSV_ISPRTKPVAAHTCWICVSITSAATVWPT_RRWPVGLQRCRHCRSCWTLPKYRCCRQVWSTWAGAA_SIPSTTRTVTVPSHGLSRPWSWSPSTERRWLR_PSTNRVRPAPLRRRSKSRSGLSMTLRVTGALINRRFSSIA_LLLLPLARRSHAKTALRPSTRFVS_RSGTQRCRLRWGCPTSPSVSILLHAKFLTLFFYMNVRKQDWIRRLCTLQRYCPSTGYPKNSARLRWI_CMTAVAKATTHCRS_CGYSKVCRRHRRRKHGRQNSLSCRCSTG_HSGSSTASATG_MLISTRQ_PRNRRWRSSTRTCWTA_RQSVNCSALGRCSCLSCCSRPRL_KQRWLI_NRTWRNPTVTSVRG_PKDGLCWLPSKEMCTILAKTSSISF_ATTATKW_TSASSSRLPTFSRWPRTKAPT_SGCRACW_NRL_S_RKTSRR_TLAESLRNSQCCSAARR_PAAMWKTTWPKSMRAKCITHETLSRV_S_WTPL_APSAARRLRRGARSP_LQKQTAIRKLSARHVMSGPNALQCSVRLPKSQLRFPNAPMFRVMSRFRRRRSGVRGSSRVWRWPTIPGSSTSARCSWVSGDYVVCAAVRGPRTRIWCRPRAGRGCATG_TDCPPTASWRTPPWCTVTSRRCPKTTILSCSLSRDRTPSSGTGSPSRVSNAVGSCALPILFDPGIWRPSGVRWMFCRSSW_PWVNPLLTSLASCSCPIPIVIILKCMASVCS_PRRWPNTGTGAFVKS_NSPETGRCRLTIPRPSRTISSSATEVPASRSGMEHARTWRTGSR_WSCFNPNASV_RYLKSCSYIPSNRLMRSCCTIRRLSTSTSEG

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MetH with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

10 show intermediate predicted evidence for PPIs

51 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MetH

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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