pyrG
mL1363
Probable CTP synthase PyrG
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1624156 – 1625928
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1363_pyrG_dna
GTAAGCACCCGCAATCCGCTACCAAGCACCTCTTTGTCAGCGGTGGCGTCGCTTCTTCGCTTGGCAAAGGACTCACCGCGAGCAGCCTCGGGCAACTGTTGACCGCTCGTGGGTTGCACGTGACAATGCAGAAACTCGACCCGTACCTCAATGTTGACCCGGGCACCATGAACCCGTTCCAGCACGGGGAGGTCTTTGTGACCGAGGATGGCGCCGAGACTGACCTCGACGTCGGCCACTACGAGCGGTTCCTGGATCGCGATCTGTCCGGCTCGGCGAATGTCACTACCGGGCAGGTGTATTCGACAGTGATCGCCAAAGAACGGCGTGGCGAATATCTCGGTGACACAGTCCAGGTGATCCCGCACATCACCGACGAGATCAAGCAGCGCATCATGGCGATGGCCCAGCCCGACGGCGGAGACAACCGCCCAGACGTCGTCATTACCGAAATCGGTGGCACCGTGGGTGATATCGAATCGCAGCCCTTTTTGGAGGCGGCACGGCAGGTCCGTCACGACCTTGGCCGGGAGAACGTCTTCTTTCTACATGTGTCGTTGGTGCCTCACCTGGCGCCTTCGGGTGAACTCAAAACCAAGCCTACCCAGCACTCAGTGGCCGCGCTGCGCAGCATCGGTATTACCCCGGATGCCCTGATCCTGCGCTGCGACCGAGATGTTCCCGAATCGTTGAAGAACAAGATTGCGCTGATGTGCGACGTTGATATCGATGGAGTCATCTCCACCCCGGACGCGCCATCGATCTATGACATACCCAAAGTGTTGCATCGTGAGGAACTCGACGCCTTTGTGGTGCGCCGACTCAATCTACCGTTCCGCGACGTGGACTGGACCGAGTGGGACGACTTGCTGCGCCGTGTTCACGAGCCTCACGGGACTGTGCGAATTGCTCTTGTAGGTAAGTACGTTGACTTTTCCGACGCCTATCTGTCAGTCTCCGAAGCGCTACATGCCGGCGGGTTCAAACATTACGCCAAGGTTGAGGTAGTTTGGGTGGCTTCCGACGATTGCGAAACTGCCACGGGCGCTGCAGCGGTGCTGGCCGACGTTCACGGTGTGCTGATCCCTGGTGGGTTCGGTATCCGCGGAATCGAAGGAAAAATCGGCGCCATCCGGTATGCTCGGGCTCGGGGGCTGCCGGTGCTTGGCCTATGCTTGGGTTTGCAATGTATCGTGATCGAGGCCACCCGCTCGGTCGGTCTCGTGCAAGCGAACTCGGCCGAATTCGAACCAGCTACACCAGATCCGGTGATCTCAACGATGGCCGATCAAAAAGAGATCGTGGCCGGCGAAGCGGATTTCGGCGGCACGATGCGGCTGGGGGCCTATCCCGCGGTTTTGCAACCGGCTTCGATCGTGGCCCAAGCGTATGGCACAACGCAGGTGTCCGAGCGACACCGGCACCGCTACGAAGTCAACAACGCCTACCGCGATTGGATCGCCGAAAGTGGGCTGCGGATTTCTGGAACTTCGCCCGACGGTTATCTGGTGGAGTTCGTCGAATATCCGGCCAACATGCATCCATTCGTTGTCGGCACCCAGGCTCACCCTGAACTGAAGAGCCGACCCACCCGGCCGCATCCACTGTTCGTCGCTTTCGTCGGGGCGGCCATCGACTACAAGTCGGCGGAGTTGCTCCCTGTGGAGATACCTGCGGTCCCGGAAATTTCTGAGCACTTGCCCAACAGCAGTAACCAGCATCGAGATGGCGTCGAGCGGTCGTTCCCGGCACCTGCAGCCCGTGGCTGAGCAC

Protein Sequence 

>ML1363_PyrG_protein
VSTRNPLPSTSLSAVASLLRLAKDSPRAASGNC_PLVGCT_QCRNSTRTSMLTRAP_TRSSTGRSL_PRMAPRLTSTSATTSGSWIAICPARRMSLPGRCIRQ_SPKNGVANISVTQSR_SRTSPTRSSSASWRWPSPTAETTAQTSSLPKSVAPWVISNRSPFWRRHGRSVTTLAGRTSSFYMCRWCLTWRLRVNSKPSLPSTQWPRCAASVLPRMP_SCAATEMFPNR_RTRLR_CATLISMESSPPRTRHRSMTYPKCCIVRNSTPLWCADSIYRSATWTGPSGTTCCAVFTSLTGLCELLL_VSTLTFPTPICQSPKRYMPAGSNITPRLR_FGWLPTIAKLPRALQRCWPTFTVC_SLVGSVSAESKEKSAPSGMLGLGGCRCLAYAWVCNVS_SRPPARSVSCKRTRPNSNQLHQIR_SQRWPIKKRSWPAKRISAARCGWGPIPRFCNRLRSWPKRMAQRRCPSDTGTATKSTTPTAIGSPKVGCGFLELRPTVIWWSSSNIRPTCIHSLSAPRLTLN_RADPPGRIHCSSLSSGRPSTTSRRSCSLWRYLRSRKFLSTCPTAVTSIEMASSGRSRHLQPVAEH

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PyrG with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

4 show intermediate predicted evidence for PPIs

34 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PyrG

Use of these data is subject to the AlphaFold Server Output Terms of Use.

You do not have permission to view notes.