polA
mL1381c
PROBABLE DNA POLYMERASE I POLA
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1648224 – 1650959
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1381c_polA_dna
AGCCGTGAGTGCAGCAATGACCGCTGAAGTCTGCGAAGACCACACCAAGCCAATGCTGATGCTGCTGGACGGCAATTCGCTGGCATTTCGCGCATTTTACGCACTGCCAACAGAGAATTTCAAGACCCGCGGTGGCCTCACCACCAACGCGGTGTACGGCTTCACCGCCATGCTGATCAACTTGCTGCGTGAGGAGGCTCCAACGCATATCGCTGCGGCGTTCGATGTATCGCGGAAAACGTTTCGCTCCGAGTGCTATGCGGGATACAAGGCTAATCGGTCATCAATCCCCGCTGAGTTCCACGGCCAGATCGACATCACTAAGGAAGTCTTAGGTGCGCTGGGTATCACGGTGTTCGCTGAGGCTGGATTCGAGGCTGACGACCTCATCGCGACGTTGGCTACTCAAGCCGAAAACGAGGGTTACCGTGTGCTGGTGGTCACCGGTGACCGCGACGCACTTCAGCTGGTCAGCAACGACGTGACGGTGCTCTATCCTCGTAAAGGCGTTAGCGAACTCACCCGCTTCACACCAGAGGCTGTTATCGAGAAGTACGGGGTGACGCCGGCGCAGTACCCCGACTTAGCGGCGCTACGTGGCGATCCCAGCGACAATCTGCCCGGTATTCCCGGCGTGGGGGAAAAGACCGCCGCCAAGTGGATCGTCGATTACGGTTCGCTACAAGGGCTGGTCGACAATGTCGAGTCGGTCCGCGGCAAGGTGGGCGAAGCGTTGCGGACGCATCTAGCCAGCGTGGTGCGCAACCGAGAGCTCACAGAGCTTGTCAAAGATGTGCCGTTGGTGCAAACCTCGGACACGCTGCGGCTGCAGCCGTGGGATCGCGACCGAATTCACCGGCTCTTCGACAACCTAGAGTTCCGGGTGTTACGTGACCGGTTGTTTGAGGCTTTGGCCGCCGCTGGAGAGCGTGTACCCGAAGTCGACGAGGGGTTTGACGTCCGCGGCGGTTTGCTGGAGTCCGGCACGGTCGGGCGGTGGCTGGCTAAGCACGCCGATGACGGACGCAGGTCTGGGCTAGCGATCGTCGGTACACATCTGCCGCACGGCGGAGACGCCACTGCGCTAGCTGTAGCCGCCGCCGACGGTAACGGCGGCTACATCGACACCGCGATGTTGACTCCCGACGACGACGACGCGCTGGCGGCTTGGTTGGCCGATCCCGACAACCCCAAAGCGCTGCATGAGGCGAAGCTGGCCATGCATGATCTCGCTGGTCGCGGTTGGACGCTAGGCGGCATCACGTCCGATACCGCGTTGGCGGCCTACTTGGTGAGGCCGGGGCAACGCAGCTTCACTCTTGACGATCTCTCACTCCGTTACCTGCGTCGCGAGCTGCGAGCAGAAACACCTGAGCAGGAACAGTTTTCGTTGCTTGACAACGTCGACGAAGTGGACAAGCAAGCCATCCAGACTCTGATACTGCGGGCCCGGGCGGTGGTAGACCTCGCCGCTGCGTTGGACGCTGAGCTGGATCTCATCGATTCTACCTCACTACTAGGTGAGATGGAGCTGCCGGTCCAACAGGTGCTGGCTGACATGGAGAAAGCGGGTATTGCGGCCGATTTGCGGTTGCTCACCGAGTTGCAGAGCCAATTCGGCGATCAGATCCGAGACGCCGCTGAGGCCGCCTACGCCGTAATCGGCAAGCAGATCAATCTGAGCTCACCCAAGCAACTGCAGGTCGTGTTGTTCGAAGAACTAGGCATGCCGAAGACCAAAAGGACCAAGACCGGCTACACTACTGACGCCGATGCTTTGCAGTCCCTGTTCTGCAAAACGGAGCACCCATTTCTGCAGCATCTGCTCACTCACCGGGACGTCACCCGACTCAAAGTCACCGTCGACGGGTTGCTGAACGCGGTCGCCGCAGATGGCCGGATTCATACCACATTCAACCAGACGATTGCGACGACCGGTCGACTGTCCTCGACAGAACCCAACCTGCAGAACATTCCAATCCGCACCAATGCCGGCCGGCAGATCCGGGACGCTTTCGTCGTTGGTTCGGAAAATAACGGCTACACCGAACTGATGACCGCCGATTACAGCCAAATCGAGATGCGGATCATGGCACACCTATCCCGGGATGAGGGGCTCATCGAGGCCTTCCACACTGGGGAAGACCTGCACTCGTTTGTGGCCTCGCGGGCATTCGGTATACCTATCGAGGATATCACCCCCGAATTGCGGCGCCGGGTCAAGGCGATGTCCTACGGGCTGGCCTACGGGCTAAGCGCATACGGGTTAGCTACGCAGCTGAAAATTTCCACTGAGGAGGCGAAGCTGCAGATGGAGCAATACTTCGCTCGATTCGGCGGGGTGCGCGACTACCTGATGGATGTCGTCGAGCAGGCACGCAAGGATGGATACACCTCGACGGTGTTAGGCCGTCGACGTTACCTGCCCGAGCTAGACAGCAGTAATCGCCAGATACGGGAGGCGGCAGAGCGGGCAGCGCTCAACGCGCCGATCCAGGGCAGTGCGGCCGACATCATTAAGGTGGCAATGATCGCGGTTGACAAGTCGCTCAAACAGGCGAAGCTGGCGTCGCGAATGCTGCTACAGGTACACGATGAATTGCTGTTCGAAGTCGCGATCGGTGAGCGCGAGCAGATCGAGGCCATGGTGCGCGAGCAGATGGGCAGTGCCTACCCCTTGGACGTGCCGCTGGAAGTAAGTGTTGGCTTTGGCCGCTCGTGGGGTGCTGCTGCGCA

Protein Sequence 

>ML1381c_PolA_protein
SRECSNDR_SLRRPHQANADAAGRQFAGISRILRTANREFQDPRWPHHQRGVRLHRHADQLAA_GGSNAYRCGVRCIAENVSLRVLCGIQG_SVINPR_VPRPDRHH_GSLRCAGYHGVR_GWIRG_RPHRDVGYSSRKRGLPCAGGHR_PRRTSAGQQRRDGALSS_RR_RTHPLHTRGCYREVRGDAGAVPRLSGATWRSQRQSARYSRRGGKDRRQVDRRLRFATRAGRQCRVGPRQGGRSVADASSQRGAQPRAHRACQRCAVGANLGHAAAAAVGSRPNSPALRQPRVPGVT_PVV_GFGRRWRACTRSRRGV_RPRRFAGVRHGRAVAG_ARR_RTQVWASDRRYTSAARRRRHCASCSRRRR_RRLHRHRDVDSRRRRRAGGLVGRSRQPQSAA_GEAGHA_SRWSRLDARRHHVRYRVGGLLGEAGATQLHS_RSLTPLPASRAASRNT_AGTVFVA_QRRRSGQASHPDSDTAGPGGGRPRRCVGR_AGSHRFYLTTR_DGAAGPTGAG_HGESGYCGRFAVAHRVAEPIRRSDPRRR_GRLRRNRQADQSELTQATAGRVVRRTRHAEDQKDQDRLHY_RRCFAVPVLQNGAPISAASAHSPGRHPTQSHRRRVAERGRRRWPDSYHIQPDDCDDRSTVLDRTQPAEHSNPHQCRPADPGRFRRWFGK_RLHRTDDRRLQPNRDADHGTPIPG_GAHRGLPHWGRPALVCGLAGIRYTYRGYHPRIAAPGQGDVLRAGLRAKRIRVSYAAENFH_GGEAADGAILRSIRRGARLPDGCRRAGTQGWIHLDGVRPSTLPARARQQ_SPDTGGGRAGSAQRADPGQCGRHH_GGNDRG_QVAQTGEAGVANAATGTR_IAVRSRDR_ARADRGHGARADGQCLPLGRAAGSKCWLWPLVGCCCA

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PolA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

36 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PolA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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