uvrB
mL1387
PROBABLE EXCINUCLEASE ABC (SUBUNIT B - HELICASE) UVRB
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1661669 – 1663765
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1387_uvrB_dna
GCGTCGGTGGCCGCTTCGAGGTGATCAGCCCGCACGAACCGGCTGGTGACCAGCCAGCGGCTATTGATGAGTTGCAGCGACGGATCCTGGCGGGGGAGCGTGACGTAGTGTTACTTGGTGCCACCGGTACCGGAAAGTCAGCAACCACCGCCTGGCTTATCGAACGGTTGCAGCGACCTACTTTGGTGATGGCGCCGAATAAGACGCTGGCAGCTCAACTTGCGAACGAACTGCGTGGGATGTTGCCGCACAACGCGGTCGAGTACTTCGTATCATACTATGATTACTATCAGCCAGAAGCGTACATCGCACAGACCGACACCTATATCGAAAAAGACAGCTCCATCAACGACGACGTGGAGCGGCTGCGGCACTCCGCCACGTCGTCGCTGCTGTCGCGGCGCGATGTGGTAGTGGTGGCTTCGGTGTCATGCATTTACGGCCTAGGTACTCCACAGTCCTACCTGGACCGCTCTGTCGAGCTAGCGGTTAGCAACGAGGTGCCTCGCGACGGCCTATTGCGGCTGCTGGTCGACGTGCAATACACCCGCAATGATCTGTCCTTCACCCGCGGCTCCTTCCGGGTGCGCGGCGACACTGTGGAGATCATTCCGTCCTACGAGGAGCTGGCGGTTCGTATCGAGTTCTTCGGCGACGAGATCGAGGCGTTGTACTACCTACACCCCCTCACCGGCGAGGTGATTCGTCAGGTCGACTCGCTACGGATCTTCCCCGCCACCCACTATGTAGCCGGTCCCGAGCGGATGGCGCAGGCAATCTCAGCCATCGAGGAAGAACTTGCCGAGCGGCTCGCCGAATTCGAACGCCAGGGCAAGCTGCTGGAGGCGCAGCGGCTGCGGATGCGGACCAACTACGACATCGAAATGATGCGGCAGGTCGGGTTCTGCTCAGGTATAGAGAATTACTCCCGCCATATCGACGGCAGGGGGCCGGGCACGCCGCCGGCAACGTTGCTCGATTACTTCCCGGAGGACTTTTTGCTCGTCATCGACGAGTCGCATGTCACCGTCCCGCAAATCGGCGGCATGTACGAAGGTGACATGTCGCGGAAGCGTAACCTCGTCGAATATGGGTTTCGGCTGCCGTCAGCGTGTGACAACCGCCCGCTGACCTGGGAGGAATTCGCCGATCGGATCGGGCAAACGGTGTACCTATCGGCCACCCCGGGACCGTATGAGCTCAGCCAGTCCGGTGGTGAGTTCGTCGAGCAGGTGATCCGACCGACCGGTTTGGTCGACCCGAAAGTGGTAGTCAAGCCAACCAAGGGGCAAATCGACGACCTGATTGGCGAAATCCGCAAACGCGCCAACGCCGACCAACGGGTCTTGGTAACGACGCTGACCAAGAAAATGGCCGAAGACCTCACCGACTACTTGCTAGAGATGGGTATCCGGGTGCGCTACCTGCACTCCGAGGTCGACACCTTGCGGCGGGTAGAACTGCTGCGTCAACTGCGGCTTGGCGACTATGACGTGTTGGTCGGCATTAACCTGTTGCGCGAAGGCCTCGACCTGCCCGAGGTGTCGCTGGTGGCGATCCTGGACGCCGACAAGGAAGGCTTCCTGCGGTCGGCGCGCAGCCTAATCCAGACCATAGGCCGGGCAGCCCGCAACGTCTCCGGTGAAGTACATATGTATGCCGACACGATCACTGATTCGATGACCGAAGCCATCGATGAAACCGAACGGCGACGGGCAAAGCAGATCGCCTACAACAATGCCAATGGTATCGACCCACAGCCGCTGCGCAAGAAGATCGCCGACATCCTCGACCAGGTCTATCGCGAGGCCGACGACACCGACACCGTTCAAGTGGGTGGATCGGGACGTAACGTGTCCCGCGGTCGGCGCGCCCAGAGTGAACCTGTTCGCTCGGTCAGCGTCGGAGTGTTCGAGGGTCGCGACACCGCTGGTATGCCGCGTGCAGAACTGGCTGACCTGATCAAAGATCTTACCGCCCAAATGATGGCCGCCGCAAGTGACTTGCAATTCGAGCTGGCCGCGCGCTTCCGTGACGAGATCGCAGACCTCAAAAAGGAACTGCGTGGGATGGACGCGGCGGGCCTCAAATGAATGT

Protein Sequence 

>ML1387_UvrB_protein
ASVAASR_SARTNRLVTSQRLLMSCSDGSWRGSVT_CYLVPPVPESQQPPPGLSNGCSDLLW_WRRIRRWQLNLRTNCVGCCRTTRSSTSYHTMITISQKRTSHRPTPISKKTAPSTTTWSGCGTPPRRRCCRGAMW_WWLRCHAFTA_VLHSPTWTALSS_RLATRCLATAYCGCWSTCNTPAMICPSPAAPSGCAATLWRSFRPTRSWRFVSSSSATRSRRCTTYTPSPAR_FVRSTRYGSSPPPTM_PVPSGWRRQSQPSRKNLPSGSPNSNARASCWRRSGCGCGPTTTSK_CGRSGSAQV_RITPAISTAGGRARRRQRCSITSRRTFCSSSTSRMSPSRKSAACTKVTCRGSVTSSNMGFGCRQRVTTAR_PGRNSPIGSGKRCTYRPPRDRMSSASPVVSSSSR_SDRPVWSTRKW_SSQPRGKSTT_LAKSANAPTPTNGSW_RR_PRKWPKTSPTTC_RWVSGCATCTPRSTPCGG_NCCVNCGLATMTCWSALTCCAKASTCPRCRWWRSWTPTRKASCGRRAA_SRP_AGQPATSPVKYICMPTRSLIR_PKPSMKPNGDGQSRSPTTMPMVSTHSRCARRSPTSSTRSIARPTTPTPFKWVDRDVTCPAVGAPRVNLFARSASECSRVATPLVCRVQNWLT_SKILPPK_WPPQVTCNSSWPRASVTRSQTSKRNCVGWTRRASNEC

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding UvrB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

10 show intermediate predicted evidence for PPIs

65 show weak predicted evidence for PPIs

View all pooled AlphaFold results for UvrB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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