uvrA
mL1392
PROBABLE EXCINUCLEASE ABC (SUBUNIT A - DNA-BINDING ATPase) UVRA
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1668341 – 1671250
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1392_uvrA_dna
CTGACCGCTTGATCGTCAAGGGTGCCCGTGAGCACAACCTGCGAAGCGTCGATCTCGACCTGCCGCGGGATTCATTGATCGTCTTCACCGGGCTGTCCGGATCAGGCAAGTCTTCACTGGCATTCGACACCATCTTCGCCGAGGGCCAGCGCCGCTACGTGGAGTCACTGTCGGCCTACGCGCGCCAATTCCTTGGACAGATGGACAAGCCGGACGTCGACTTCATCGAGGGTCTTTCCCCGGCGGTGTCCATCGACCAGAAGTCGACGAACCGCAACCCGAGGTCGACCGTAGGAACAATCACCGAGGTGTACGATTACCTGCGATTGTTATATGCGCGTGCTGGCACACCGCACTGCCCGATCTGTGGCGAGCAGATCTCCCGTCAGACCCCGCAGCAAATTGTCGATCAGGTGCTGGTGCTGCCGGAGGGCACCCGGTTTTTGGTGCTCGCTCCGGTGGTGCGTACCCGCAAGGGCGAGTTCGCGGACCTGTTCGACAAGCTCAACGCACAGGGCTACAGCCGGGTTCGGGTCGACGATGTAGTGTACCCGTTGAGCGATCCACCGAAGCTTAAAAAACAAGAAAAGCACGACATCGAGGTGGTAGTGGACCGACTCACCGTCAAGATCGCCGCCAAGCAGCGGCTCACCGACTCGGTGGAAACCGCCCTGAACCTAGCTGACGGCATCGTAGTGTTGGAATTTCCCGACGATCACGACGAACGTGGCCACCCGCGCGAACAGTGCTTCTCCGAGAAGTTAGCTTGCCCCAATGGGCACCCCCTGGCCGTTGACGACCTGGAACCACGCTCGTTCTCGTTCAACTCGCCCTACGGCGCCTGTCCCGAATGTGTGGGCTTGGGAATCCGCAAAGAGATCGACTCAGATCTAGTGGTGCCCGACCCGGATCGCACTCTGGCCGAGGGTGCGGTGGCGCCGTGGTCGGCGGGGCGCACCGCGGAGTACTTCACCCGGATGATGGCCGGGCTCGGCGAGAAACTGGGATTCGACGTTGACACGCCATGGCGCAAACTCCCGGCCAAGGCCCGCAAGGCGATTCTTGAAGGTTCCGATCATCAGGTGCATGTGCAGTACCACAACCGGTACGGTCGACCCCGCTCATATTACGTTGATTTTGAGGGCGTGCTGACGTTCTTACAGCGCAAGATGGAGCAGACCGAGTCCGAGCAGATGAAGGAACGCTACGAGGGTTTCATGCGTAATATCCCCTGCCCGGTGTGTCAGGGGACCCGACTCAAGCCAGAGATTCTGGCGGTGACGTTAGCGGCAGGGGAGCGGGGCGCGAAGTCCATTGCCGAGGTCTGCGAGCTGTCCATCGCGGACTGCTCGGCTTTTCTGAACGCGCTTATCCTTGGTGTGCGCGAGCAGGCGATAGCGGGGCAGGTGCTCAAAGAAATCCAGTCGCGACTCGGCTTTTTGCTCGACGTCGGGCTGGAGTACCTCTCGCTGTCTCGGGCGGCAGCCACGCTGTCTGGTGGTGAGGCCCAACGCATTCGGCTAGCTACCCAAATCGGTTCCGGTCTGGTGGGCGTGCTCTACGTCCTTGACGAACCATCCATCGGGCTACACCAGCGCGACAACCGTCGACTCATCGAAACTCTCACGCGGTTAAGGGCGTTGGGGAACACACTGATCGTCGTCGAACATGACGAAGACACCATCGCACACGCTGACTGGGTCGTCGACATCGGCCCGGGCGCCGGTGAGCATGGCGGCCAAATCGTGCACAACGGGACCTACCGTGAACTGCTGGCAAATAAGGATTCGATTACCGGTGCTTACCTGTCGGGTCGGGAAAGCATTGCCACCCCCACACGTCGGCGTTCCGTCGACCGTAAGCGTGAGCTCACCGTCGTCGGGGCCCGCGAGCACAATCTGCGCGGCATCGACGTGTCGTTTCCGCTTGGCGTGTTGACCTCGGTAACCGGTGTGTCGGGCTCCGGCAAGTCAACTTTGGTCAATGATATCCTGGCAGCGGTGCTGGCCAACAGGCTCAACGGCGCTCGGCAAGTTCCGGGTCGCCATACCCGAGTCACCGGCCTAGAACATCTGGACAAGCTGGTGAGGGTGGACCAGTCGCCGATCGGCCGCACGCCGCGATCCAACCCGGCCACCTACACCGGGGTATTTGACAAGATCCGAATCTTGTTCGCGGCTACCACCGAGGCGAAAGTCCGTGGTTACCAACCCGGTAGATTCTCGTTCAACGTTAAGGGCGGTCGCTGCGAGGCGTGCACCGGTGACGGCACCATCAAGATCGAGATGAACTTCTTGCCGGACGTGTATGTACCTTGTGAAGTGTGCCAGGGCGCCCGGTACAACCGAGAAACCCTTGAAGTACACTACAAAGGCAAGGCCATATCCGAAGTGTTGGACATGTCGATCGAGGAAGCGGCGGAGTTCTTTGAGCCGATCATCGGCATTAACCGTTATCTGCGCACGCTGGTCGATGTCGGTCTGGGCTATGTCCGACTGGGTCAGCCCGCGCCGACGTTGTCGGGTGGTGAGGCGCAGCGGGTCAAACTGGCGTCCGAGTTGCAGAAGCGTTCGACCGGGCGCACCATCTACATTCTCGACGAACCCACCACAGGACTGCATTTCGACGATATCCGCAAACTTCTTAACGTCATCAATGGTCTTGTTGACAAAGACAATACGGTGATCGTGATCGAACACAACCTGGACGTGATCAAAACGTCGGACTGGATCGTCGATATGGGTCCCGAGGGTGGCGCTCAAGGTGGAACCGTTGTCGCCGAAGGCACTCCGGAGGATGTCGCAGCGGTTCCGGAAAGCTACACTGGCAAATTTCTCGCCGAAGTCGTTGGCGCAGGGTGCGCGCCTGCACGCACACCACGGCGACGCCGCACAGTCACCGCCTAAGTCC

Protein Sequence 

>ML1392_UvrA_protein
LTA_SSRVPVSTTCEASISTCRGIH_SSSPGCPDQASLHWHSTPSSPRASAATWSHCRPTRANSLDRWTSRTSTSSRVFPRRCPSTRSRRTATRGRP_EQSPRCTITCDCYMRVLAHRTARSVASRSPVRPRSKLSIRCWCCRRAPGFWCSLRWCVPARASSRTCSTSSTHRATAGFGSTM_CTR_AIHRSLKNKKSTTSRW_WTDSPSRSPPSSGSPTRWKPP_T_LTAS_CWNFPTITTNVATRANSASPRS_LAPMGTPWPLTTWNHARSRSTRPTAPVPNVWAWESAKRSTQI_WCPTRIALWPRVRWRRGRRGAPRSTSPG_WPGSARNWDSTLTRHGANSRPRPARRFLKVPIIRCMCSTTTGTVDPAHITLILRAC_RSYSARWSRPSPSR_RNATRVSCVISPARCVRGPDSSQRFWR_R_RQGSGARSPLPRSASCPSRTARLF_TRLSLVCASRR_RGRCSKKSSRDSAFCSTSGWSTSRCLGRQPRCLVVRPNAFG_LPKSVPVWWACSTSLTNHPSGYTSATTVDSSKLSRG_GRWGTH_SSSNMTKTPSHTLTGSSTSARAPVSMAAKSCTTGPTVNCWQIRIRLPVLTCRVGKALPPPHVGVPSTVSVSSPSSGPASTICAASTCRFRLAC_PR_PVCRAPASQLWSMISWQRCWPTGSTALGKFRVAIPESPA_NIWTSW_GWTSRRSAARRDPTRPPTPGYLTRSESCSRLPPRRKSVVTNPVDSRSTLRAVAARRAPVTAPSRSR_TSCRTCMYLVKCARAPGTTEKPLKYTTKARPYPKCWTCRSRKRRSSLSRSSALTVICARWSMSVWAMSDWVSPRRRCRVVRRSGSNWRPSCRSVRPGAPSTFSTNPPQDCISTISANFLTSSMVLLTKTIR_S_SNTTWT_SKRRTGSSIWVPRVALKVEPLSPKALRRMSQRFRKATLANFSPKSLAQGARLHAHHGDAAQSPPKS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding UvrA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

9 show intermediate predicted evidence for PPIs

64 show weak predicted evidence for PPIs

View all pooled AlphaFold results for UvrA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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