sigC
mL1448
PROBABLE RNA POLYMERASE SIGMA FACTOR%2C ECF SUBFAMILY%2C SIGC
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1740908 – 1741462
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1448_sigC_dna
TCGCGTCTAGCGGCGACGAGGCCGTTACTGACCTCGCCTTAGCAGCTGCACGCGGGAGCAAACGAGCACTGGAGGCGTTTATCAAAGCCACCCAGCAAGATGTGTGGCGGTTCGTCGCCTACTTGTCGGATGTGGGCAATGCCGACGATTTGACTCAGGAGACGTTCCTGCGAGCAATTGGAGCCATCGAGCGGTTTTCCGGACATTCCAGCGGCCGAACCTGGCTGCTGGCCATTGCGCGCCGGGTGGTCGCCGACCACATCCGCCGGGCCCAAACACGACCCCGCACCACCTTCGACGGCTACCCCGAACGCATGCTCAACGCCGACCGCCACGCCCGCGGATTCGAAGACCTCGTTGAAGTGACAACAATGATCGCCAACCTTGCCACCGAACAACGCGAAGCCCTGTTGCTCACTCAGCTTCTCGGGCTGCCCTACGCCGATGCCGCCGCGGTGTGCGGTTGCCCGGTGGGGACCATTCGATCCCGGGTCGCCCGTGCCCGGGACGCGCTGTTGGCCGACACCGAGCATAACCACCTGACCGGGTAGAAAT

Protein Sequence 

>ML1448_SigC_protein
SRLAATRPLLTSP_QLHAGANEHWRRLSKPPSKMCGGSSPTCRMWAMPTI_LRRRSCEQLEPSSGFPDIPAAEPGCWPLRAGWSPTTSAGPKHDPAPPSTATPNACSTPTATPADSKTSLK_QQ_SPTLPPNNAKPCCSLSFSGCPTPMPPRCAVARWGPFDPGSPVPGTRCWPTPSITT_PGRN

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding SigC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

10 show intermediate predicted evidence for PPIs

72 show weak predicted evidence for PPIs

View all pooled AlphaFold results for SigC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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