nadE
mL1463c
PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING])
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1759309 – 1761351
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1463c_nadE_dna
GGCGATGGACTTCTACAACTCCTACAGCCAGGGTTTTGTCCGAGTCGCTGCGTGCACCCATCACGCTTCCATCGGCGATCCGACGACCAACGCTGCATCGGTTTTGCGGTTGGCCCGCCAGTGTCACGACGACGGAGTTGCCGTGGCCGTCTTCCCAGAGCTGACGTTGTCCGGTTACTCGATCGAGGATATTTTGCTCCAAGACCTTTTGCTCGAGGCTGTCGAGGACACCGTGCTCGATATCGTTGTGGCCTCCGCGGATCTGTTGCCGGTTTTGGTCATTGGTGCCCCGCTGCGCTACCGGCATCGCATCTACAACACCGCAGTGATCATCCACCGCGGTGTGGTACTCGGTGTGGCACCCAAGTCGTACCTGCCCACCTACCGGGAGTTCTACGAGCGTCGTCAACTCGCACCTGGAGACGACGAACACGGCACCATTGGCATCGGTGACTTGCGGGCCCCGTTCGGTCCTGATCTGCTGTTCGCCGCGGCCGACTTGCTCGGCTTGGTGCTGCACGTTGAAATCTGCGAGGACATGTTCGTGCCGGTGCCGCCCAGCGCCGAAGCCGCGTTGGCAGGCGCGACGGTGTTGGCGAACCTGTCGGGCAGCCCGATCACGATCGGCCGCGCCGAAGACCGTCGCCTGCTGGCCCGCTCGGCGTCGTTGCGGTGTCTAGCCGCTTACGTCTATGCCGCTGCGGGGGAGGGTGAGTCCACGACCGACTTGGCTTGGGACGGTCAGACGATGATCTGGGAGAATGGGGTGCTGCTCGCGGAATCCGAGCGTTTCCCCAAGGGGGAGCACCGCTCGGTCGCTGACGTCGACACCGAACTGCTTCGATCCGAGCGATTGCGCATGGGCACCTTCAACGACAACCGTCGCCGTCACCGAGCGTTAGTTGAGCCATTCCGGCGCATTGAGTTTCGGCTCGAGCCGCCGGTCGGCAACATCGGATTGTTGCGGGAGGTTGAGCGTTTTCCTTTTGTCCCAGCCGATCCGCAGCGTTTACAGCAAGATTGCTACGAGGCTTACAATATCCAAGTTTCCGGGCTTGAACAACGGTTGCGTGCGTTGGACTACCCGAAGGTTGTAATCGGAGTTTCTGGCGGGCTAGATTCGACACATGCGCTGATCGTCGCCGCGCGCGCAATGGACCGGGAAGGACGCCCGCGCAGCGACATTCTCGCATTCACGCTGCCCGGGTTCGTGACCGGAGATCGCACCAAAAGCAATGCCACCGAGCTGTGTCGCGCACTGGGTGTTACTTTCACGGAAATAGATATCAGAGACACCGCAACGTTGATGCTGAAAAAAATCGGTCATCCGTTCTCACGCGGCGAGGTTTCCTACGATGTCACTTTCGAGAACGTCCAGGCAGGAGTGCGCACCGATTATCTCTTTCGGCTGGCCAACCAGCATGGTGGCATCGTGCTCGGCACCGGTGACCTGTCAGAGCTGGGGCTGGGTTGGTCGACCTACGGTGTGGGTGATCAAATGTCCCACTATAATATCAATGCTGGTGTTCCAAAGACATTGGTGCAACACCTGATCCGCTGGGTCATTGCCTCGAGTCAATTCGAGGAGCAGGTCGATAAGGTGCTGCAGTCGGTGCTCGACACCGAGATCACTCCGGAACTTATTCCAAGCGATGGTGAAGAAAAACTTCAGAGCACTGAAGCAAAGGTTGGTCCGTTTGCCCTACAAGATTTTTCGTTGTTTCAGGTCTTGCGGTACGGATTTCGTCCATCGAAGATCGCTTTCCTGACCTGGCACGCTTGGAGCGATCCCAATTGCGGCAAGTGGCCACCTGGATTCCCAGAAGATAAACGATTGTCCTACTCACTTAAGGAAATTAGGCATTGGCTGCAGATTTTTGTGCAACGTTTCTATTCGTTCAGTCAGTTCAAAAGATCAGCGCTGCCCAATGGCCCCAAGGTGTCTCATGGAGGAGCGTTATCGCCGCGTGGGGATTGGCGAGCCCCGTCAGATATGTCCGCACGGATCTGGCTCGACGAGATCGAGCGCGAAGTGCCCGAAGA

Protein Sequence 

>ML1463c_NadE_protein
GDGLLQLLQPGFCPSRCVHPSRFHRRSDDQRCIGFAVGPPVSRRRSCRGRLPRADVVRLLDRGYFAPRPFARGCRGHRARYRCGLRGSVAGFGHWCPAALPASHLQHRSDHPPRCGTRCGTQVVPAHLPGVLRASSTRTWRRRTRHHWHR_LAGPVRS_SAVRRGRLARLGAAR_NLRGHVRAGAAQRRSRVGRRDGVGEPVGQPDHDRPRRRPSPAGPLGVVAVSSRLRLCRCGGG_VHDRLGLGRSDDDLGEWGAARGIRAFPQGGAPLGR_RRHRTASIRAIAHGHLQRQPSPSPSVS_AIPAH_VSARAAGRQHRIVAGG_AFSFCPSRSAAFTARLLRGLQYPSFRA_TTVACVGLPEGCNRSFWRARFDTCADRRRARNGPGRTPAQRHSRIHAARVRDRRSHQKQCHRAVSRTGCYFHGNRYQRHRNVDAEKNRSSVLTRRGFLRCHFRERPGRSAHRLSLSAGQPAWWHRARHR_PVRAGAGLVDLRCG_SNVPL_YQCWCSKDIGATPDPLGHCLESIRGAGR_GAAVGARHRDHSGTYSKRW_RKTSEH_SKGWSVCPTRFFVVSGLAVRISSIEDRFPDLARLERSQLRQVATWIPRR_TIVLLT_GN_ALAADFCATFLFVQSVQKISAAQWPQGVSWRSVIAAWGLASPVRYVRTDLARRDRARSARR

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding NadE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

1 shows weak predicted evidence for PPIs

View all pooled AlphaFold results for NadE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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