folC
mL1471c
PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1768990 – 1770447
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1471c_folC_dna
TGCAATGACCGCAGAGCTGCCTGACTGGGGATCCGGACGTCTTGAAACCAATGTCGCTGCTCTCACACCGGACAAGGTCGCCTCCCTGTTGCAGGTTGAACACCTGCTGGACCAGCGCTGGCCAGAGACCTGTATCGAACCGAGTTTGACTCGGATCAGTGCGTTAATGGATGTTCTCGGCTCACCGCAACTCAGTTATCCGTCGATACACGTCGCTGGCACCAACGGGAAGACCTCGGTGACGAGGATGGTTGACGCGCTGCTAACCGCGCTGCACCAGCGCACTGGCCGCTTTACCAGCCCTCACCTGCAGTCGGTAGTCGAACGCATCGCGATTGACTCAAAACCGATCAGCCCGGCGCAATATGTAGCAACTTACCGTGAGGTTGAACCGTTTGTGCAGATGATCGATGCCCAGTCGCAGTCCTCTGGGGGGCCGGCGCTGAGCAAGTTCGAGGTAGTCACCGCGATGGCGTTCGCCGCGTTCGCGAATGCGCCCGTCGACATCGCGGTGGTTGAGGTGGGCCTCGGTGGGCGATGGGATGCGACCAACGTGATTAATGCATCGGTCGCCGTGATCACCCCGGTCAGCATCGACCACGTCGAGTATCTTGGCAACGACGTTGCAGCGATCGCCCGCGAGAAGGCGGGCATTATCACGAAAGCTCCCGAAGGCGCGCCAGACACCGTCGTGGTAATCGGTCGTCAGGTACCTGCGGCGATGGGGGTGCTGTTGGCTCAATCGGCACATGCCGGCGCTCGAGTCGTCCGTCAGGATTCGGAGTTCGCGGTCTTGGACCGTCAGGTCGCAATCGGTGGTCAGGTGTTGCAGCTGCAGGGGCTTGGTGGAGTTTATAATGACATTTACCTGCCGTTACATGGCGAACACCAGGCGCACAACGCGGTCTTGGTGCTTGCTGCGGTCGAGGCGTTTTATGGTGCCGGGGTGCAGCGCCAGCTCGATGTCGAGGCGGTGCGGTCCGGTTTCGCCGCTGTCATCAGCCCCGGCAGGTTGGAACGCATGCGCAGTGCCCCGACGGTGTTCATCGACGCCGCTCACAATCCCGCCGGAGCGAATGCGTTGGCGCGCACGCTGTCTGACGAATTTAATTTCCGAACCCTGGTCGGGGTGCTCAGCGTGCTGGCAAACAAGGACGTTGATGGCATCCTGGCCGCACTGGAGCTGGTGCTGGATTATATCGTTGTGACTGACAACGGCTCGCCGCGGGCGTTGGATGTTGAGTCGCTGGCGTTGGTGGCGCGGGAGCGGTTCGGCCCCGACCGGGTAATCAGCGCGGCGAACCTGCGTGACGCTATCGACGCAGCGACTGCACTGGTCGACGACGCCGCTGCCAATGAGGAAATCGAAGGGCTCGGAGTCTCCGGCCGTGGGATCGTCATCACCGGCTCGGTGATCACCGCCGGAATCGCACGGACTTTGTTTGGCCGTGACCCACA

Protein Sequence 

>ML1471c_FolC_protein
CNDRRAA_LGIRTS_NQCRCSHTGQGRLPVAG_TPAGPALARDLYRTEFDSDQCVNGCSRLTATQLSVDTRRWHQREDLGDEDG_RAANRAAPAHWPLYQPSPAVGSRTHRD_LKTDQPGAICSNLP_G_TVCADDRCPVAVLWGAGAEQVRGSHRDGVRRVRECARRHRGG_GGPRWAMGCDQRD_CIGRRDHPGQHRPRRVSWQRRCSDRPREGGHYHESSRRRARHRRGNRSSGTCGDGGAVGSIGTCRRSSRPSGFGVRGLGPSGRNRWSGVAAAGAWWSL__HLPAVTWRTPGAQRGLGACCGRGVLWCRGAAPARCRGGAVRFRRCHQPRQVGTHAQCPDGVHRRRSQSRRSECVGAHAV_RI_FPNPGRGAQRAGKQGR_WHPGRTGAGAGLYRCD_QRLAAGVGC_VAGVGGAGAVRPRPGNQRGEPA_RYRRSDCTGRRRRCQ_GNRRARSLRPWDRHHRLGDHRRNRTDFVWP_PT

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding FolC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

12 show intermediate predicted evidence for PPIs

61 show weak predicted evidence for PPIs

View all pooled AlphaFold results for FolC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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