pepN
mL1486
PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1788674 – 1791262
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1486_pepN_dna
CCCTTCCAAACCTCACCCGGGACCAGGCTGTCGAACGCTCCGCCCTGATCACCGTCGACAGCTACCAGATCAACCTCGATCTCACCGACGGCCCCGACAACGCCCCTAGCGACCGCACGTTCCGCTCCATCACCACGGTGGTGTTTGACGCACTAGCCGGCGCCGACACCGTAATCGACATTGCTGCCGATGCCGTGCGCAGTGCCACCCTCAACGACCACGAACTCGACGTCTCCGAATACGACGAATCGACCGGTATCCCGTTACCTGGACTGGCCGATCGCAACGTTGTCGTCGTCGACGCCGACTGCCGCTACTCCAACACCGGCGAGGGCCTACATCGCTTCGTCGACCCCGTAGACGACGAGATCTACTTGTACTCGCAATTCGAAACAGCTGACGCCAAAAGGATGTTCGCCTGCTTCGACCAACCTGACCTCAAGGCCACCTTCGAGGTAGAGGTGACCGCATGCAAGAACTGGAAGGTGATCTCCAATAGCGTGTGCATCAACATCACCGAGGGGACACACACCTTCGCCACCACCCCACGTATGAGCACCTATCTGGTGGCGTTGATCGCCGGGCCATACGCTGCTTGGTACGCCAGTTACCGCGACGAACACGGTGAAATCCCGCTGGGCATCTACTGCCGAGCCTCGCTGGCACAATTCATGGACGCCGAGCGATTATTCACACAGACTAAGAAGGGATTTAATTTTTACCACAAGCACTTTGGCCTACCGTACGCGTTCGGCAAATACGATCAGCTCTTCGTCCCCGAGTTCAATGCCGGAGCAATGGAAAACGCCGGCGCGGTGACGTTCCTCGAGGACTACGTCTTCCGCAGCAAAGTCACCCGTGCTTCCTATGAACGGCGCACCGAGACGGTACTACACGAGATGGCACACATGTGGTTCGGCAATTTGGTCACCATGACCTGGTGGGACGACTTGTGGCTGAACGAGTCTTTCGCAACCTTTGCATCGGTGCTGTGTCAAAGCGAAGCCACCGAATTTACCGAAGCGTGGACGACGTTCGCCACTGTGGAAAAGTCGTGGGCTTACTGCCAGGACCAACTGCCATCCACGCACCCGATCGTCGCCGACATCCCAGACCTGGCTGCAGTCGAGGTAAACTTTGACGGCATCACTTACGCTAAAGGCGCTTCCGTATTGAAGCAGCTCGTTGCGTACGTTGGGTTAGAGCAATTCCTGGCCGGGCTGCGCGACTACTTCCGCAAACACGCATTCGCCAATGCCACTTTTGACGATCTGCTTGTCGCACTGGAAAACGCCTCCGGACGCGACTTGTCACACTGGAGTCAACAGTGGCTGAAAACCACTGGGATCAACATGCTAAGGCCAGATTTCGACGTCGACGCCGATGGCAAATTTACCCGGTTCTCGGTGATGCAAAGCGGCGCCGAACCGGGTGCGGGTGAGACTCGGGTGCACCGGCTGGCGGTCGGAATCTACGATAACTGCGGGGAAGCCGACAAACTGGTGCGGGTGCATCGGGAAGAACTCGACGTCGAGGGTACAGAAACGGAAGTACCTGCACTGGTTGGCATTTCGCAGGGCAAGCTGATTCTTGTCAATGATGACGACCTGACCTACTGCTCACTGCGGCTAGATGCCCAGTCGCTGCAAACCGCGCTACAGAGCATCGCCGACATCGCCGAACCACTGCCACGCACCCTGGTGTGGTCAACAGCCTGGGAAATGACCCGCGAGGCCGAATTGCGTGCCCGCGACTTCGTGGCGCTGGTTTCAGGTGCCTTGCATGCCGAAACCGAGGTCGGGGTGGCACAGCGGCTGCTACTGCAGGCGCAAACGGCGCTGGGCTCATATGCCGATCCAGACTGGGCGCGTGATTACGGCTGGCCGCAGTTCGCCGACCGGATCTTGGAATTGGCGCGCGCCGCAGTATCCGGGTCGGATCACCAGCTCGCTTTCATCAACACGCTGTGCTCATCGGTGCTGTCGCCCCGGCATGTGCAGACATTGGCTGCCCTGCTCAACGATGACCCCACCGAGCTGGGATTGCCTGGCGTGCAGGTCGATACCGATCTGCGCTGGCGCATCGTAACCGCACTCGCCACCGCCGGGACTCTCGATGCCAATGGGCCGCAGACACCATGGATCGACGCCGAGATGCAACGTGACCCGACGGCCGCCGGCAAGCGCCACGGCGCTCAGGCCGCAGCAGCACGGCCGCAGTCCGACATTAAGGACAAGGCGTTCACTACGGTGGTCGAAGATGACACCCTGACTAACGCTGCAGGCCGGGCAATAATCGCGGGCATTGTCGCACCAGGACAAGGTGAGCTACTCAAGCCGTTCACCGCGCGCTACTTCGCCGCGATACCCGGTGTCTGGACACGGCGATCCAGCGAAGTAGCGCAAACGGTGGTGATCGGCCTGTATCCCCACTGGGACATCAGCGACGTGGGTATCGCCGCTGCTGAGGAGTTCCTAACCGCCCCGGAGTCAAAAGTACCACCAGCCTTGCGCCGGCTGGTGCTGGAGGGCCAGGCTGCGGTGAAGCGCGCACTACGCGCTCGCATGTTCGACAGTGCTGACTAAATCG

Protein Sequence 

>ML1486_PepN_protein
PFQTSPGTRLSNAPP_SPSTATRSTSISPTAPTTPLATARSAPSPRWCLTH_PAPTP_STLLPMPCAVPPSTTTNSTSPNTTNRPVSRYLDWPIATLSSSTPTAATPTPARAYIASSTP_TTRSTCTRNSKQLTPKGCSPASTNLTSRPPSR_R_PHARTGR_SPIACASTSPRGHTPSPPPHV_APIWWR_SPGHTLLGTPVTATNTVKSRWASTAEPRWHNSWTPSDYSHRLRRDLIFTTSTLAYRTRSANTISSSSPSSMPEQWKTPAR_RSSRTTSSAAKSPVLPMNGAPRRYYTRWHTCGSAIWSP_PGGTTCG_TSLSQPLHRCCVKAKPPNLPKRGRRSPLWKSRGLTARTNCHPRTRSSPTSQTWLQSR_TLTASLTLKALPY_SSSLRTLG_SNSWPGCATTSANTHSPMPLLTICLSHWKTPPDATCHTGVNSG_KPLGSTC_GQISTSTPMANLPGSR_CKAAPNRVRVRLGCTGWRSESTITAGKPTNWCGCIGKNSTSRVQKRKYLHWLAFRRAS_FLSMMTT_PTAHCG_MPSRCKPRYRASPTSPNHCHAPWCGQQPGK_PARPNCVPATSWRWFQVPCMPKPRSGWHSGCYCRRKRRWAHMPIQTGRVITAGRSSPTGSWNWRAPQYPGRITSSLSSTRCAHRCCRPGMCRHWLPCSTMTPPSWDCLACRSIPICAGAS_PHSPPPGLSMPMGRRHHGSTPRCNVTRRPPASATALRPQQHGRSPTLRTRRSLRWSKMTP_LTLQAGQ_SRALSHQDKVSYSSRSPRATSPRYPVSGHGDPAK_RKRW_SACIPTGTSATWVSPLLRSS_PPRSQKYHQPCAGWCWRARLR_SAHYALACSTVLTKS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PepN with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

23 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PepN

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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