dfrA
mL1518c
DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1832480 – 1832977
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1518c_dfrA_dna
GCGTATGACGGTGGTGGGCCTGATCTGGGCTCAGTCGACGACGGGTGTGATTGGGCGCGACGGCGGCATGCCATGGCGAGTGCCTGAGGATCTGACTCGCTTCAAACAGCTGACGATGGGTCACCCGGTGGTGATGGGCCGACGGACCTGGGATTCGTTGCCGGTTGGGGTTCGCCCGCTGCCAGGCCGCCGAAATATCGTGTTGAGCCGACAAATTGACTTTATGGCTGAGGGAGCGGAGGTGTTCGGTTCTCTCGAAGAGACCATTTCCAATCTCGAGACCGAGCCTGAGATGTGGGTGATTGGCGGTGAGCAGATCTACCGGCTTGCGTTGCCGCTGGCGACCCGTTGCGGGGTCACCGAGGTAGACACCTACCTGCTTCATGAGGACGATGACGTGCTGGCCCCGGTGCTCGACGATACATGGGTGGGTGTGACGGGAGAGTGGCTGGTGAGCTGCTCCGGGCTGCGGTACCGGTTGCACAGCTATCATCGTTC

Protein Sequence 

>ML1518c_DfrA_protein
AYDGGGPDLGSVDDGCDWARRRHAMASA_GSDSLQTADDGSPGGDGPTDLGFVAGWGSPAARPPKYRVEPTN_LYG_GSGGVRFSRRDHFQSRDRA_DVGDWR_ADLPACVAAGDPLRGHRGRHLPAS_GR_RAGPGARRYMGGCDGRVAGELLRAAVPVAQLSSF

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding DfrA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

21 show weak predicted evidence for PPIs

View all pooled AlphaFold results for DfrA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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