aceE
mL1651
Probable pyruvate dehydrogenase E1 component aceE (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 1989171 – 1991981
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1651_aceE_dna
TCGAGTTCGCGCGCCCGGATCTGGCCAAAAACCCTAGCAGCACAAACGAATCCAACAGCGTTCGGGTGATCCGCGAAGGTGTGGCGTCGTATTTGCCCGATATCGACCCCGAGGAGACAGCGGAGTGGCTGGAGTCCTTCGACGAATTGCTGAAGCACTCAGGGCCGTCGCGGGCACGATATCTGATACTACGGCTACTGGAGCGGGCCGGCGAGCAGCGGGTGACGATCCCGGCGTTGACATGGACCGACTACGTCAACACCATCCCGACCGAGCTCGAGCCGTGGTTCCCCGGAGACGAGGACATCGAACGTCGCTACCGCACCTGGATCAGATGGAACGCGGCAATTATGGTGCACCGCGCGCAACGACCGGGTGTGGGCGTCGGTGGTCATATCTCTACCTATGCTTCGTCCGCTGCGCTCTACGAGGTAGGGTTCAACCACTTTTTCCGAGGAAAGTCGCATCCCAGCGGCGGAGATCAGGTATTCATCCAGGGCCACGCGTCCCCCGGAATTTACGCCCGTGCCTTCCTGGAAGGCCGATTGTCCGCAGACCAGCTTGATGGTTTCCGCCAGGAGCACAGTCATCCGGGAGGCGGGTTGCCGTCCTACCCACACCCACGACTGATGCCCGACTTCTGGGAATTCCCCACCGTGTCGATGGGTCTGGGCCCGCTCAATGCCATTTACCAGGCACGGTTCAACCGCTATCTTCATGACCGGGGTATCAAGGATACCTCCGACCAACACGTGTGGTGTTTTTTAGGCGACGGTGAAATGGACGAGCCCGAAAGCCGCGGGCTCGCACATGTCGCGTCCCTCGAAGACCTGGACAATCTGATCTTCGTCATCAACTGCAATCTGCAGCGCCTCGACGGTCCAGTACGTGGTAACGGCAAGATCATCCAGGAGCTGGAGTCATTCTTCCGCGGAGCCGGTTGGAACGTCATCAAGGTAGTGTGGGGCCGTGAATGGGACGCGCTGCTACATGCCGACCGGGACGGCGCCCTGGTCGATCTGATGAACGCCACCCCTGACGGTGATTACCAAACGTACAAAGCCAACGATGGCCGCTTTGTCCGCGACCATTTCTTCGGGCGCGACCCTCGTACCAAGGCTCTGGTGGAACATATGAGCGACCAAGAGATCTGGAACCTCAAGCGCGGCGGTCACGACTACCGTAAAGTTTACGCCTCCTATCGCGCCGCCGTCGACCACAAGGGACAGCCAACAGTGATCTTGGCCAAGACCATCAAGGGTTACGCGCTGGGCAAACATTTCGAGAGCCGCAATGCCACTCACCAGATGAAAAAGCTTACGCTGGAAGATCTTAAGGAGTTTCGTGATACCCAGCGGATTCCGATTTCAGACACCGAATTAGAGGAAAATCCTTACCTACCACCGTATTACCATCCCGGACCCGACTCACCGGAAATCCGTTATCTGCTCGACCGACGCCGCGCCCTCGGGGGTTTTCTGCCCGAGCGCCGGACAAAGTCCGGCGCGCTAACGCTTCCCGGCCGCGACACCTACGCCGCGTTGAAGACCGGATCGGGTCAGCAGGAAGTCGCCACCACCATGGCGATCGTGCGCACATTCAAAGAAGTGTTGCGACACAAGGAAGTCGGCCCACGGATCGTCCCGATCATTCCCGACGAAGCGCGCACGTTCGGCATGGACTCGTGGTTTCCGTCGTTGAAGATCTATAACCACAACGGCCAGCTTTACACCGCCGTCGACGCACAACTGATGCTGGCGTACAAGGAGAGCGAAGTCGGGCAGATCCTGCACGAAGGCATTGACGAGGCCGGGTCGGTGGGCTCATTCATCGCGGCAGGCACATCGTATTCGACGCACAACGAGCCAATGATTCCAATCTACATCTTCTATTCGATGTTCGGGTTCCAACGCACCGGCGACGGCCTGTGGGCCGCGGCCGACCAAATGGCGCGGGGCTTCCTACTCGGGGCCACCGCGGGACGTACCACGCTGACCGGCGAGGGGCTGCAACACGCCGACGGCCACTCGTTGCTGTTAGCGGCCACCAATCCGGCAGTCGTCACGTACGATCCGGCGTTCGCCTACGAAATCGCCTATATCGTCGAAAGCGGGCTGACCCGGATGTTTGGGGAGGACCCGGAAAACGTGTTCTTTTACATCACCGTCTACAACGAACCATACCCACAGCCACCCGAGCCGGAGAACTTCGATCCCGACGGAGTACTGCGCGGCATGTACCGCTACTACACGGCTAAGGAACAACGTTCCAACAAGGCGCACATCTTGGCCTCCGGGGTGTCAATGCCTGCGGCACTGACGGCAGCCGAGATGCTGTCCACCCAGTGGGATGTCGCTGCCGACGTATGGTCGGTGACCAGTTGGGGCGAACTGAACCGCGACGGGATGTCCATCGAAACGGCCCGGCTGCGTTACCCCGACCAACCGACGAGCGTCCCCTACGTGACCCAGGTCTTATCCGAAGCCCGCTCGGATAACGCCGGACCGGTAATCGCCGTATCGGACTGGATGCGCGCGGTGCCCGAACAGATCCGACCATGGGTTCCTGGCACCTACGTCACGCTGGGCACTGACGGGTTCGGTTTTTCCGACACCCGTACAGCCACTCGACGCTATTTCAACACCGATGCCGAATCGCAGGTGGTCGCGGTATTGGAGGCGCTGGCACGTGACGGTGAGATCGACCCGTCGGTGCCGGTCGCGGCCACACGTCAATACCAGATCGACGACGTGCAGGCCGCCCCAGAGCAGACTTCTGATCCGGGACCGGGAGTTCAGAACTGACATAATC

Protein Sequence 

>ML1651_AceE_protein
SSSRARIWPKTLAAQTNPTAFG_SAKVWRRICPISTPRRQRSGWSPSTNC_STQGRRGHDI_YYGYWSGPASSG_RSRR_HGPTTSTPSRPSSSRGSPETRTSNVATAPGSDGTRQLWCTARNDRVWASVVISLPMLRPLRSTR_GSTTFSEESRIPAAEIRYSSRATRPPEFTPVPSWKADCPQTSLMVSARSTVIREAGCRPTHTHD_CPTSGNSPPCRWVWARSMPFTRHGSTAIFMTGVSRIPPTNTCGVF_ATVKWTSPKAAGSHMSRPSKTWTI_SSSSTAICSASTVQYVVTARSSRSWSHSSAEPVGTSSR_CGAVNGTRCYMPTGTAPWSI__TPPLTVITKRTKPTMAALSATISSGATLVPRLWWNI_ATKRSGTSSAAVTTTVKFTPPIAPPSTTRDSQQ_SWPRPSRVTRWANISRAAMPLTR_KSLRWKILRSFVIPSGFRFQTPN_RKILTYHRITIPDPTHRKSVICSTDAAPSGVFCPSAGQSPAR_RFPAATPTPR_RPDRVSRKSPPPWRSCAHSKKCCDTRKSAHGSSRSFPTKRARSAWTRGFRR_RSITTTASFTPPSTHN_CWRTRRAKSGRSCTKALTRPGRWAHSSRQAHRIRRTTSQ_FQSTSSIRCSGSNAPATACGPRPTKWRGASYSGPPRDVPR_PARGCNTPTATRCC_RPPIRQSSRTIRRSPTKSPISSKAG_PGCLGRTRKTCSFTSPSTTNHTHSHPSRRTSIPTEYCAACTATTRLRNNVPTRRTSWPPGCQCLRH_RQPRCCPPSGMSLPTYGR_PVGAN_TATGCPSKRPGCVTPTNRRASPT_PRSYPKPARITPDR_SPYRTGCARCPNRSDHGFLAPTSRWALTGSVFPTPVQPLDAISTPMPNRRWSRYWRRWHVTVRSTRRCRSRPHVNTRSTTCRPPQSRLLIRDREFRTDII

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding AceE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

39 show weak predicted evidence for PPIs

View all pooled AlphaFold results for AceE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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