leuC
mL1685c
PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2030179 – 2031636
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1685c_leuC_dna
GAGGCGCTTGGAGATGGATAACGAGAGGAAACAAGTGGGTGGCGCCCGCAAACCGCGCACGTTGGCCGAAAAGGTTTGGGACGACCACGTTGTGGTAGCCGGTCAGGGCTACCATCAAGATCGGGGTCCCGATTTGATTTACATCGATCTACATTTGGTGCACGAGGTCACCAGCCCGCAGGCTTTCGATGGCCTGCGCTTGGCCGGCCGGTGGGTGCGGCGCCCCGATTTAACAGTGGCCACCGAGGATCACAACGTGCCCACCGTCGACATCGACAAGCCGATCGCTGACCCGGTGTCGCGCATTCAAGTGGAGACGTTGCGGCGCAACTGCGCCGAATTTGGTGTCCGGTTACACCCGATGGGCGATATCGAGCAGGGCATCGTTCATGTCGTAGGGCCACAGTTAGGCCTCACTCAACCGGGCATGACGATCGTTTGCGGCGACAGTCACACCTCTACCCATGGCGCTTTTGGTGCAATCGCGATGGGCATCGGCACCTCGGAGATCGAGCATGTACTCGCTACCCAAACGCTGCCGTTGCGCCCATTCAAGACAATGGCGGTCACTGTCGATGGGCGGTTGCCCGCCGGCGTCACAGCCAAGGACATCATCCTTGCGTTGATTGCTAAGATTGGCACCGGCGGCGGGCAGGGCTATGTACTCGAATACCGGGGCAGTGTCATCGAATCGATGTCCATGGAAGGACGGATGACGATCTGCAACATGAGCATCGAAGCCGGTGCTCGAGCAGGAATGGTGGCTCCCGACGAGACTACCTACGAGTTCTTACGTGACCGTCCGCACGCACCGACTGGCAAGCAATGGGATGCCGCAGTAGCCTACTGGCAACAGCTGCGCACTGACGACGACGCTGTGTTCGACACCGAGGTCTATCTCGATGCGACCTCGTTGAGCCCGTTTGTCACCTGGGGGACAAACCCCGGTCAAGGAGTGCCGTTGGCCGCATCTGTGCCTGATCCCGAACTGATGATTGACGATGTTGCCCGACAAGCCGCCGAGAAAGCTTTGGCGTACATGGACCTTCGCCCAGGTACACCGATGCGCGATATTGCGGTCGATGCGGTGTTCGTTGGGTCGTGTACCAACGGCCGCATTGAGGATCTGCGGTTGGTGGCCGATGTGTTACGTGGCCACAAGGTGGCCGACGGTGTGCGGATGCTGATCGTCCCCGGCTCGATGCGGGTACGTGCGCAGGCTGAAGCCGAGGGGCTCGGTGAGATTTTTATTACTGCGGGAGCGCAGTGGCGGCAGCCGGGTTGTTCGATGTGTCTGGGCATGAACCCCGATCAGCTTGCGCCCGGGGAGCGGTGCGCTGCGACGTCCAACCGAAACTTCGAAGGACGGCAAGGCAAGGGTGGCCGTACACATTTGGTATCCCCGGCCGTCGCCGCTGCCACCGCGGTTCGCGGCACTTTCTCTGCTCCGGCCGATTT

Protein Sequence 

>ML1685c_LeuC_protein
EALGDG_REETSGWRPQTAHVGRKGLGRPRCGSRSGLPSRSGSRFDLHRSTFGARGHQPAGFRWPALGRPVGAAPRFNSGHRGSQRAHRRHRQADR_PGVAHSSGDVAAQLRRIWCPVTPDGRYRAGHRSCRRATVRPHSTGHDDRLRRQSHLYPWRFWCNRDGHRHLGDRACTRYPNAAVAPIQDNGGHCRWAVARRRHSQGHHPCVDC_DWHRRRAGLCTRIPGQCHRIDVHGRTDDDLQHEHRSRCSSRNGGSRRDYLRVLT_PSARTDWQAMGCRSSLLATAAH_RRRCVRHRGLSRCDLVEPVCHLGDKPRSRSAVGRICA_SRTDD_RCCPTSRRESFGVHGPSPRYTDARYCGRCGVRWVVYQRPH_GSAVGGRCVTWPQGGRRCADADRPRLDAGTCAG_SRGAR_DFYYCGSAVAAAGLFDVSGHEPRSACARGAVRCDVQPKLRRTARQGWPYTFGIPGRRRCHRGSRHFLCSGRF

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding LeuC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

45 show weak predicted evidence for PPIs

View all pooled AlphaFold results for LeuC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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