ligA
mL1705c
PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2055751 – 2057835
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1705c_ligA_dna
TGCGAGGGTGAGTTCCCCCGAAGCTGACCCTATCGGACCCGAGGTGTTGCAGCAGTGGCGAAAGCTGACCGAAGAGGTGCGTGAACACCAGTTCCGTTACTATGTGCGTGACGCGCCGATCATCTCTGACGCGGAGTTTGATGCTCTGCTGGACAGGCTCACTGTGCTGGAGGAACAGCATCCCGAGCTGTGCACGCCCGATTCACCTACCCAGCTGGTCGGCGGTGCTGGCTTCATGACTGATTTCGTGGCGACCGAGCATCTCGAACGGATGTTCAGCCTCGACAACGCCTTCAGTGGGGATGAACTCAATGCCTGGGTCACTCGCATCCGCGCAGAGATCGGTAATGACGCCCATTATTTGTGTGAGCTCAAGATCGACGGTGTCGCATTGTCGTTGGTCTACCGGGATGGACGCCTGACCCGCGCCACGACTCGGGGCGATGGTCGCACCGGCGAAGACGTCACGCTGAACGCGCGGACCATCGAAGATGTGCCGGAACGGCTGACCGTCAGCGATATTTACCCGCTGCCAGAGGTTCTTGAGGTCCGCGGCGAGGTGTTCTTCCGAGTGGTGGACTTTCAAGCGCTTAACACGAGCCTCGTTGAGGAGGGCAAGAATCCGTTCGCTAACCCACGAAACAGCGCGGCGGGCTCGCTGCGCCAGAAGGATCCGGCGGTCACGGCTCACCGTAAACTGCGAATGATCTGTCATGGACTGGGGCACATCGAAGGCTTTCGTCCCGCTACCCAGCATCAGGCTTACTTAGCTTTACGGGACTGGGGGTTGCCGGTGTCCGAGCATACGACGCTGGTCAACGACATAGCTGGCGTCCAGGGATGCATCGCATACTGGGCCGAACATCGTCACGAGGTGGACCATGAAATCGACGGGATAGTGGTCAAAATCGACGAGGTTACGTTGCAGCGCAGGCTGGGTTCCACCTCGCGAGCTCCACGATGGGCCATCGCTTACAAGTACCTACCCGAGGAGGCGCAGACCAAGCTGCTCGACATCCGGGTGAACGTCGGCCGCACCGGTCGGGTTACGCCATTCGCGTTCATGACGCCCGTGAAAGTTGCCGGGTCGACGGTCGGGCAGGCGACCTTGCACAACCCTTCTGAGGTCAAACGCAAAGGTGTGCTGATCGGTGACACCGTGGTGATCCGCAAGGCCGGCGACGTGATTCCCGAAGTTTTGGGACCTGTGGTTGACTTGCGCGACGGGTCCGAACGTGAATTTGTGATGCCCACAACGTGTCCCGAGTGCGGTACTACGTTAGCGCCAGAAAAGGAAGGCGATGCCGACATCCGTTGCCCCAATGCCAGGAGCTGCCCGGGGCAACTGCGAGAGCGAGTGTTTCACGTCGCTAGCCGCAGCGCTCTGGACATTCAGGGGTTGGGTTACGAGGCCGGTGTGGCGTTGCTGGCTGCGCAAGTGATCACTAGCGAGGGCGACCTGTTCACCCTCACCGAGAAGGCCTTGTTGCGCACCGAGCTTTTCCGCAACAAGGCAGGGGAGTTGTCGGCGAATGGCAAACGGTTGCTAGTCAACGTCGACAAAGCCAAAACTGCACCGCTGTGGCGAGTGCTGGTGGCGTTGTCGATCCGGCATGTCGGGCCGACGGCTGCGCGAGCCTTGGCCACCGAGTTCGGCAGCGTTGACGCAATCTTGGCCGCGTCCCCTGAACAACTGGCCGCTGTCGAGGGTGTAGGGACCACCATCGCGGCCGCGGTTACCGAGTGGTTCACCGTCGACTGGCATCGCGTGATTGTCAATAAGTGGCGGGCTGCCGGGGTGCGGATGGTCGATGAGCGTGACACCAGCGTGCTGCCCACATGCGAAGGGTTGACCATCGTGGTCACTGGTTCTTTAGCAGGGTTTTCCCGTGACGATGCCAAGGAGGCGATCGTGGCGCGCGGAGGCAAGGTCGCTGGTTCGGTATCGAAGAAGATCGCCTACGTGGTCGTAGGCGACTTGCCGGGATACAAATATGACAAGGCGGTCGAGCTCGGGGTGCCGATCCTCAACGAGGACGGGTTTCGCCTGTTGCTTGAGCAGGGACCTCCGGTGCAGCAAGTCGT

Protein Sequence 

>ML1705c_LigA_protein
CEGEFPRS_PYRTRGVAAVAKADRRGA_TPVPLLCA_RADHL_RGV_CSAGQAHCAGGTASRAVHARFTYPAGRRCWLHD_FRGDRASRTDVQPRQRLQWG_TQCLGHSHPRRDR__RPLFV_AQDRRCRIVVGLPGWTPDPRHDSGRWSHRRRRHAERADHRRCAGTADRQRYLPAARGS_GPRRGVLPSGGLSSA_HEPR_GGQESVR_PTKQRGGLAAPEGSGGHGSP_TANDLSWTGAHRRLSSRYPASGLLSFTGLGVAGVRAYDAGQRHSWRPGMHRILGRTSSRGGP_NRRDSGQNRRGYVAAQAGFHLASSTMGHRLQVPTRGGADQAARHPGERRPHRSGYAIRVHDARESCRVDGRAGDLAQPF_GQTQRCADR_HRGDPQGRRRDSRSFGTCG_LARRVRT_ICDAHNVSRVRYYVSARKGRRCRHPLPQCQELPGATARASVSRR_PQRSGHSGVGLRGRCGVAGCASDH_RGRPVHPHREGLVAHRAFPQQGRGVVGEWQTVASQRRQSQNCTAVASAGGVVDPACRADGCASLGHRVRQR_RNLGRVP_TTGRCRGCRDHHRGRGYRVVHRRLASRDCQ_VAGCRGADGR_A_HQRAAHMRRVDHRGHWFFSRVFP_RCQGGDRGARRQGRWFGIEEDRLRGRRRLAGIQI_QGGRARGADPQRGRVSPVA_AGTSGAASR

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding LigA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

18 show weak predicted evidence for PPIs

View all pooled AlphaFold results for LigA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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