iscS
mL1708c
PROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) (NITROGENASE METALLOCLUSTERS BIOSYNTHESIS PROTEIN NIFS)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2060896 – 2062128
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1708c_iscS_dna
GGCGCTCTTGATCCGGCAGGCTCCGATCGCCGGTATCCTAAAGTGCGTCATGGCCTACCTGGATCACGCCGCTACTACCCCGATGCACCCCGCCGCCATCGAGGCGATGACGACCGCGCTAGGCACTGTCGGCAACGCGTCGTCGCTGCACACCAGTGGGCGAGTGGCGCGGCGGCGGATTGAGGAATCCCGCGAGCTGATCGCCGACAAACTTGCTGCGCGCCCGTCCGAGGTGATTTTCACTGCAGGTGGCACCGAGAGCGACAACTTGGCCGTCAAAGGCATCTATTGGGCGCGCCGTGACGCGCAGCCGTGCCACCGACGCATCGTTACAACCGAGGTGGAACACCACGCCGTGTTGGACTCGGTGAACTGGCTGGTCGAACACGAAGGTGCGGAGGTGACGTGGTTGCCCACCGCTGCCGACGGCTCGGTATCGGCGTTCGGGCTGCGGGAGGCGCTGCAGCAACACAACGACGTCGCACTCGTATCGGTGATGTGGGCCAATAACGAAGTCGGCACAGTCATGCCAGTCGTCGAACTCGCCGCCGTCGCTGCCGAGTTCGGTGTTCCGATGCACAGTGATGCGATACAAGCGGTGGGTCAGCTGCCGGTAAAGTTCGGTGTCAGCGGGCTGTCGGCGATGAGTGTGGCCGCGCATAAATTTGGTGGCCCGCCTGGTGTGGGCGCGTTGCTGCTGCGCCGGGACATCAGCTGTGTTCCGTTGTTGCATGGTGGTGGGCAGGAGCGCGATATTCGTTCCGGCACTCCCGGTGTCGCCAGCGTTGTTGGGATGGCAGCGGCGGCACAGATCGCGGTGGACGGATTGGAGATCAACAGTATCCGGCTGCAGGTGTTGCGTGACCGCTTGATCGAGGGTGTGCTGGCGACGATTGACGACGTTGCACTCAACGGTGCCCGCGATCGGATGCGGCTTCCAGGTAACGCGCACTTCATCTTCCGTGGTTGCGAAGGTGATGTGCTATTGATGCTGTTGGATGCCAACGGAATCGAATGCTCGACTGGATCGGCCTGCACCTCCGGTGTTCCGCAGCCGTCGCACGTTCTGATAGCGATGGGCGCCGACCCGGCTAGTGCGCGCGGATCGCTTCGTCTTTCTTTGGGGCACAATAGTGTTGAGGTCGACGTTGAAGAGGTGCTGCGGGTGCTGCCGGGGGCGGTGGATCGCGCCCGCCGAGCATCGCTGGCAGCGGCAGGGGCCGGGGGTGTTGG

Protein Sequence 

>ML1708c_IscS_protein
GALDPAGSDRRYPKVRHGLPGSRRYYPDAPRRHRGDDDRARHCRQRVVAAHQWASGAAAD_GIPRADRRQTCCAPVRGDFHCRWHRERQLGRQRHLLGAP_RAAVPPTHRYNRGGTPRRVGLGELAGRTRRCGGDVVAHRCRRLGIGVRAAGGAAATQRRRTRIGDVGQ_RSRHSHASRRTRRRRCRVRCSDAQ_CDTSGGSAAGKVRCQRAVGDECGRA_IWWPAWCGRVAAAPGHQLCSVVAWWWAGARYSFRHSRCRQRCWDGSGGTDRGGRIGDQQYPAAGVA_PLDRGCAGDD_RRCTQRCPRSDAASR_RALHLPWLRR_CAIDAVGCQRNRMLDWIGLHLRCSAAVARSDSDGRRPG_CARIASSFFGAQ_C_GRR_RGAAGAAGGGGSRPPSIAGSGRGRGCW

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding IscS with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

21 show weak predicted evidence for PPIs

View all pooled AlphaFold results for IscS

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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