nrdE
mL1734c
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2094331 – 2096412
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1734c_nrdE_dna
CAACGCGATGTTGAATCTGTACGATGCGGACGGCAAGATCCAATTCGACAAGGACGTACTCGCGGCCCGCCAATTCTTCCTGCAGCATGTCAATCAGAACACGGTCTTTTTCCATAACCAGGACGAGAAGCTGGACTATCTGATCCGCGAGAATTACTACGAGCGTGAGGTGCTCGATCAGTACTCGCGTAACTTTGTCAAGTCGCTGCTGGATCGTGCCTACGCCAAGAAGTTTCGGTTCTCAACGTTTCTTGGTGCGTTCAAGTATTATACCTCTTACACGCTGAAGACGTTCGACGGGAAGCGGTATTTAGAGCGCCTCGAAGACCGGGTCTGCATGGTCGCACTCACGTTGGCGGCCGGTGACACCGGCTTGGCCGAGAAGCTCGTCGACGAGATCATCGACGGCCGATTCCAGCCAGCTACCCCAACTTTTTTGAACTCGGGCAAGAAACAACGCGGCGAACCGGTGAGCTGTTTTTTGCTGCGCATTGAGGATAACATGGAGTCGATCGGGCGATCGGTCAACTCCGCGCTACAGCTATCCAAGCGTGGCGGAGGAGTTGCTTTGCTGCTGAGCAACATTCGTGAGCATGGTGCACCGATCAAGAACATCGAACACCAGTCTTCGGGCGTAATTCCGATCATGAAGTTGCTTGAAGATGCGTTCTCGTATGCCAATCAGTTGGGCGCCCGCCAAGGCGCTGGTGCGGTGTACCTGCATGCTCATCACCCTGACATCTACCGCTTCTTGGACACTAAGCGGGAGAATGCCGACGAGAAGATCCGGATCAAGACGCTGAGCCTGGGGGTGATAATTCCCGACATCACCTTTGAGCTGGCTAAGCGTAACGAAGACATGTACCTGTTCTCGTCGTACGACGTCGAGCGGGTTTACGAGGTGCCGTTCGCCGATATTTCGGTGACTGAGAAGTATTATGAGATGCTCGATGACGCACGCATCCGCAAGACCAAGATCAAGGCGCGGGAGTTTTTCCAGAAGCTGGCCGAGCTGCAGTTCGAGTCCGGTTACCCCTATGTCATGTTCGAGGACACGGTGAACCGGGCCAACCCCATTGAAGGTAAGATCACTCACTCGAATCTATGCTCGGAGATCCTGCAGGTGTCCACGCCGTCGTTGTTTAACGACGACTTGTCGTATGCCAAAGTGGGCAAGGACATTTCATGTAACCTGGGATCGCTGAACATTGCCAAGACGATGGACTCACCGGATTTCGCGCAGACGGTTGAGGTGGCGATTCGCGCGTTGACTGCGGTGAGCGACCAGACGCACATCAAGTCGGTGCCCTCGATCGAGCAGGGTAACAATGATTCCCACGCGATCGGGCTGGGGCAGATGAACCTGCATGGCTACTTGTCCCGTGAAGGAATCTTCTACGGTTCCGAAGAGGGAGTCGATTTCACCAACATTTACTTCTATACGGTGTTGTTTCACGTGTTGCTGGCTTCGAACTCTATCGCGATCGAACGAGGTACCTTCTTCAAAGGTTTCGAGCGGTCCAAGTACGCGTCGGGAGAGTTCTTCGACAAATACATCGAGCAGACGTGGGAGCCGAAGACCGATAAAGTGCGTCAGTTATTCGCTGAGGCAGCGATCCGTATTCCGACCCAAAACGACTGGAAGCGGCTGAAGGAGTTGGTGGTCGCACACGGCATCTACAACCAGAACCTGCAGGCGGTGCCGCCGACCGGATCGATCTCCTATATCAACCATTCGACGTCGTCGATCCACCCGATCGTGTCGAAAGTTGAGATCCGTAAGGAAGGAAAAATTGGCCGAGTTTACTATCCGGCGCCCTATATGACCAATGACAATCTGCAGTACTACCAGGACGCTTATGAGATCGGGTACCAGAAGATCATCGACACATACGCGGCGGCCACCCAGCACGTCGACCAAGGGCTCTCACTGACGTTGTTCTTCAAAGACACCGCCACCACCCGGGACGTGAACAAGGCGCAGATTTATGCGTGGCGCAAGGGAATCAAGACGCTGTATTACATTCGGCTGCGGCAGATGGCGCTGGAAGGCACCGAAGTCGAGGGCTGCGTGTCTTGCAC

Protein Sequence 

>ML1734c_NrdE_protein
QRDVESVRCGRQDPIRQGRTRGPPILPAACQSEHGLFP_PGREAGLSDPRELLRA_GARSVLA_LCQVAAGSCLRQEVSVLNVSWCVQVLYLLHAEDVRREAVFRAPRRPGLHGRTHVGGR_HRLGREARRRDHRRPIPASYPNFFELGQETTRRTGELFFAAH_G_HGVDRAIGQLRATAIQAWRRSCFAAEQHS_AWCTDQEHRTPVFGRNSDHEVA_RCVLVCQSVGRPPRRWCGVPACSSP_HLPLLGH_AGECRREDPDQDAEPGGDNSRHHL_AG_A_RRHVPVLVVRRRAGLRGAVRRYFGD_EVL_DAR_RTHPQDQDQGAGVFPEAGRAAVRVRLPLCHVRGHGEPGQPH_R_DHSLESMLGDPAGVHAVVV_RRLVVCQSGQGHFM_PGIAEHCQDDGLTGFRADG_GGDSRVDCGERPDAHQVGALDRAG_Q_FPRDRAGADEPAWLLVP_RNLLRFRRGSRFHQHLLLYGVVSRVAGFELYRDRTRYLLQRFRAVQVRVGRVLRQIHRADVGAEDR_SASVIR_GSDPYSDPKRLEAAEGVGGRTRHLQPEPAGGAADRIDLLYQPFDVVDPPDRVES_DP_GRKNWPSLLSGALYDQ_QSAVLPGRL_DRVPEDHRHIRGGHPARRPRALTDVVLQRHRHHPGREQGADLCVAQGNQDAVLHSAAADGAGRHRSRGLRVLH

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding NrdE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

4 show intermediate predicted evidence for PPIs

30 show weak predicted evidence for PPIs

View all pooled AlphaFold results for NrdE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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