mutB
mL1799c
PROBABLE METHYLMALONYL-CoA MUTASE LARGE SUBUNIT MUTB (MCM)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2177910 – 2180186
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1799c_mutB_dna
AGCCACGATGACTGTGCGTGACGTCGGCGGCCAGCAGGATAGAGAAACTACATTCGTGGTCGGCAGTTTCGCCGATATCCCGCTGCGCAGCGATCGTGTCGTGTGGCCACCCTCCGAAGCTGCGGTCGAAAAGCATGTTTTCTCAGCCGCTTCAGCACACGGGTACACAGTTGATCAACTGCACTGGCATACGCCGGAAGGTATCGACGTCAAACCGGTCTACATCGCTGCCGACCGTGCCGCCGCCGAGGCCGGCGGCTACCCGTTGCATAGCTTCCCCGGTGAGCCGCCTTACCTGCGCGGACCTTATCCGACGATGTATGTCAACCAGCCGTGGACAATCCGTCAATACGCTGGGTTTTCCACCGCCGCAGATTCCAACGCATTTTACCGTCGGAACCTGGCAGCCGGCCAGAAGGGCCTGTCGGTAGCCTTCGACCTGGCTACTCACCGCGGGTACGACTCCGACCATCCTCGTGTCCAGGGTGATGTCGGAATGGCTGGTGTGGCAATCGATTCTATCCTCGACATGCGACAATTGTTCGATGGCATAGACCTCTCAGCGGTTTCGGTATCGATGACGATGAACGGTGCTGTGCTGCCGATCCTGGCGCTGTATGTGGTAGCAGCTGAGGAACAGGGTGTTCCTCCGGAGAAGCTGGCAGGCACTATTCAAAACGATATCCTCAAAGAGTTCATGGTCCGCAACACCTACATCTACCCACCTGAGCCATCGATGCGGATCATATCCGATATATTCGCCTACACCAGCGCCAAGATGCCGAAGTTCAACTCCATCTCGATCTCTGGCTACCATATACAAGAAGCAGGCGCCACAGCGGATTTGGAACTGGCATATACCTTGGCCGATGGTGTCGACTACATCAAGGCGGGCTTGGACGCTGGGCTGGACATTGACACTTTTGCGCCGCGGTTGTCCTTCTTTTGGGGCATCGGGATGAACTTCTTCATGGAAGTTGCCAAACTGCGTGCTGGCCGGCTGTTATGGAGTGAACTGGTCGCCAAATTTGGACCCCAAAGCCCAAAATCCCTATCACTGCGCACCCATTCGCAAACCTCTGGATGGTCGTTGACCGCCCAGGACCCGTTCAACAACGTAGCCCGCACCTGTATCGAGGCGATGGCCGCAACACAGGGCCATACCCAGTCGCTGCACACCAACGCGTTGGACGAGGCGTTGGCGCTGCCAACGGACTTTTCCGCCCGGATCGCCCGCAATACTCAGCTTGTATTGCAACAGGAGTCGGGCACTACGCGGCCGATTGACCCGTGGGGAGGCTCTTACTATGTGGAGTGGCTGACCCATCAACTGGCTGCCCGTGCTCGTACTCATATCGCCGAGGTTGCCGAGCATGGCGGCATGGCTGCGGCTATCAGCGACGGCATCCCCAAGCTGCGCATCGAGGAGGCTGCTGCGCGCACCCAGGCCCGCATCGACTCCGGGCGTCAGCCGGTGGTCGGGGTCAACAAGTACCAAGTCGACCAGGATCACGAGATTGAGGTACTCAAAGTCGAGAACAGTCGGGTGCGTGCTGAACAAGTGGCCAAATTGCAGCAGCTGCGGGCAAACCGGGATCAGTTGGCGGTCGACGCGGCTCTGGCCGAGCTGTCTGGTGCCGCTGGGGCCCACGGCCGTGCCGGAGATAATTTGTTGGCGCTTGCTATCAACGCGGCCCGGGTTCAAGCTACTGTCGGCGAGATCTCCGATGCGCTGGAGAGAGTATATGGGCGTCACCAAGCGAAGATCCGTACCATCACCGGGGTCTACCGTCGGGAAGTGGGAGAAGCTGGGAAGGCCACCGATATCGCAAACGCTACAGAACTAGTCAAAAAATTCGCCGAGGCTGATGGTCGTCGACCCAGGATTCTGGTGGCCAAGATGGGCCAGGACGGCCACGACCGCGGGCAGAAGGTTGTTGCGACGGCATTCGCCGACCTCGGGTTTGACGTCGATGTCGGATCGCTGTTCTCCACGCCCGAAGAGGTCGCCCGCCAGGCTGCCGACAACGATGTGCATGTGATAGGTGTGTCGTCGCTGGCCGCTGGCCACCTGACGCTGGTGCCGGCGCTCCGAGACGCGCTTGCTGACGTGGGCCGGCCTGACATCATGATTGTGGTGGGCGGCGTGATCCCGCCTGATGACTTTGATGAGTTGTATGCTGCCGGGGCTACTGCCATCTTCCCTCCTGGGACGGTGATAGCCTACGCCGCAATTGGCTTGCTGCATAAGCTCGCCGGCCGGCTGGGGTACACTCT

Protein Sequence 

>ML1799c_MutB_protein
SHDDCA_RRRPAG_RNYIRGRQFRRYPAAQRSCRVATLRSCGRKACFLSRFSTRVHS_STALAYAGRYRRQTGLHRCRPCRRRGRRLPVA_LPR_AALPARTLSDDVCQPAVDNPSIRWVFHRRRFQRILPSEPGSRPEGPVGSLRPGYSPRVRLRPSSCPG_CRNGWCGNRFYPRHATIVRWHRPLSGFGIDDDERCCAADPGAVCGSS_GTGCSSGEAGRHYSKRYPQRVHGPQHLHLPT_AIDADHIRYIRLHQRQDAEVQLHLDLWLPYTRSRRHSGFGTGIYLGRWCRLHQGGLGRWAGH_HFCAAVVLLLGHRDELLHGSCQTACWPAVME_TGRQIWTPKPKIPITAHPFANLWMVVDRPGPVQQRSPHLYRGDGRNTGPYPVAAHQRVGRGVGAANGLFRPDRPQYSACIATGVGHYAAD_PVGRLLLCGVADPSTGCPCSYSYRRGCRAWRHGCGYQRRHPQAAHRGGCCAHPGPHRLRASAGGRGQQVPSRPGSRD_GTQSREQSGAC_TSGQIAAAAGKPGSVGGRRGSGRAVWCRWGPRPCRR_FVGACYQRGPGSSYCRRDLRCAGESIWASPSEDPYHHRGLPSGSGRSWEGHRYRKRYRTSQKIRRG_WSSTQDSGGQDGPGRPRPRAEGCCDGIRRPRV_RRCRIAVLHARRGRPPGCRQRCACDRCVVAGRWPPDAGAGAPRRAC_RGPA_HHDCGGRRDPA__L__VVCCRGYCHLPSWDGDSLRRNWLAA_ARRPAGVHS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MutB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

22 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MutB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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