hemZ
mL1805c
FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2185785 – 2186795
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1805c_hemZ_dna
AACGGCAATGCTTTTCGATGCAGCTCTACTTTTGTCCTTCGGCGGTCCGGACGGACCCGAGCAGGTGCGGCCGTTTCTGGAGAACGTCACTCGGGGATGCAACGTGCCACCCGAACGCCTTGATGAAGTTACCAAGCATTACCTGCATTTCGGTGGAGTGTCGCCAATCAATGGGATCAACCTCGCCCTGGTCAATGAGCTGCAAGTGGAACTGGACCTGCCCGTCTATTTCGGCAACCGTAACTGGGAACCCTACATAGAGGATTCCGTTGTGACCATGCGAGACGATGGTATTCGTTGTGCTGCTGTGTTCATCACGTCGGCGTGGAGTGGCTATTCCAGTTGCACGCGATATGTTGAAGCCATTGCCCGTGCTCGTCGGCGAGCTGGTACGGGCGCGCCCAATCTGGTTAAATTGCGGCCCTACTTCGATCATCCGCTTTTCGTCGAGATGTTCGTCGATGCCATCACGGCTGCTGCCGCCAGCTTGCCCGCTGCGCTGCGCAGCGAAGCGCGGCTAGTGTTCACCGCGCATTCGGTTCCGGTGGCTACTGACCGACGCTGCGGTCCTGCGCTCTATAGCCGCCAAGTCGGTTATGCTGCAAGGCTCGTCGCGGCCGGTGCTGGATACGCCGACTACGACCTGACCTGGCAGTCTCGGTCGGGGCCGCCGTATGTTCCGTGGTTAGCGCCCGATGTTGGCGATCAACTCATGACGCTGGCGTCCGCCGGCACCAAAGCCGTCATCGTCTGTCCAATCGGGTTTGTCGCTGACCATATTGAGGTGGTGTGGGATCTAGATCACGAATTGCGATCTCAAGCAGACGCGGCGGGCGTCGCGTTCGCCCGGGCCGCTACACCTAACGCCGATCGGCGGTTCGCCCGGCTGGCCGCAAGTTTGATCGACGAACTCACGCACGACCGCGTGCCCGTTCGGGTGAATGGCTCCGATCCGGTGCCGGGTTGCCTGGCCAGCATCAATGGCGTGCCGTGCGATCTACCGCACTGTGT

Protein Sequence 

>ML1805c_HemZ_protein
NGNAFRCSSTFVLRRSGRTRAGAAVSGERHSGMQRATRTP__SYQALPAFRWSVANQWDQPRPGQ_AASGTGPARLFRQP_LGTLHRGFRCDHARRWYSLCCCVHHVGVEWLFQLHAIC_SHCPCSSASWYGRAQSG_IAALLRSSAFRRDVRRCHHGCCRQLARCAAQRSAASVHRAFGSGGY_PTLRSCAL_PPSRLCCKARRGRCWIRRLRPDLAVSVGAAVCSVVSARCWRSTHDAGVRRHQSRHRLSNRVCR_PY_GGVGSRSRIAISSRRGGRRVRPGRYT_RRSAVRPAGRKFDRRTHARPRARSGEWLRSGAGLPGQHQWRAVRSTALC

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HemZ with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

20 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HemZ

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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