acn
mL1814
PROBABLE IRON-REGULATED ACONITATE HYDRATASE ACN (Citrate hydro-lyase) (Aconitase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2195139 – 2197973
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1814_acn_dna
GTAGCAAAGATTCGGTGAACTCGTTTTCAGCCCGCGACACCCTGAAAATCGGCGACAACAGTTACCAAATCTATCGTCTGGACGCCGTCTCCAATACCAAGAGACTTCCATACAGTCTCAAAGTACTCGCCGAAAACCTACTACGCAACGAAGACGGCAAGAATATCACCAAAGATCACATCGAAGCGATAGCAAACTGGGATAGGCAGGCGGAACCCAGCATCGAAATCCAGTACACGCCGGCCCGTATCGTCATGCAGGACTTCACAGGCGTGCCGTGTATCGTCGACTTGGCCACCATGCGGGAGGCCATCGGGGATCTCGGCGGCAACCCGGAAAAAGTCAACCCACTGGCGCGGGTTGACTTGGTGATTGACCACTCAGTGATCGCCGATCTGTTTGGCCGCGCCGACGCGTTCGAGCGCAATGTTGAAATCGAGTACCAGCGCAACGGCGAGCGTTATCAGTTCCTGCGCTGGGGACAAGGAGCGTTCAACGACTTCAAGGTGGTACCACCGGGCACCGGCATTGTGCACCAGGTAAACATCGAATATCTGGCTAGTGTCGTGATGACTCAGGAGAATACCCAAGGAACAGTAGTGGCATACCCCGACACCTGCGTAGGCACCGACTCGCACACCACGATGGTCAACGGGCTCGGCGTCCTAGGCTGGGGCGTAGGTGGCATCGAAGCTGAGGCCGCCATGTTGGGCCAGCCGGTGTCGATGCTGATCCCGTGGGTGGTCGGCTTCAAGCTGAGTGGTGAGATTCAGCCAGGTGTTACAGCCACCGACGTCGTACTGACTGTCACCGAAATGTTGCGCAGGCACGGTGTTGTTGGCAAGTTCGTCGAGTTCTACGGCGAGGGCGTGGCCGAGGTACCGCTGGCCAATCGCGCCACTCTGGGCAATATGAGCCCTGAATTCGGTTCCACTGCAGCAATTTTTCCGATCGACGAAGAGACGATTAACTACCTGCGGTTCACCGGGCGCACGCCTGAGCAAGTTGCCCTGGTCGAGGGTTACGCCAAAGAGCAAGGCATGTGGCACGACCCCAAGAATGAGCCGACGTTCTCCGAATACCTCGAACTAAACCTCTCCGATGTGGTACCGTCGATCTCCGGACCGAAACGTCCGCAGGACCGAATCTGCTTGGCGCAAGCCAAGTCCACGTTCCGCGCGCAAATTCCTAAGTATGTTGACGGCAGTTCGCTCCACAACCAACATTCGAAGTTGGACGAGGTAGTCGAGGAGACATGCCCAGCCAGCGACCCGGGGAAGCTGTCGTTCACCAACAACGATGAGGTGGTAATGCAATCTGCGGCCGCGCATGCGAACGGCCGAGTAAGCAACCCGGTGCGCATCAAGACGCAAGAACTCGGTGAGTTCGTGCTCGACCACGGCGCGGTGGTGATCGCCGCGATCACATCTTGCACCAACACCTCCAATCCTGAGGTTATGTTGTGTGCGGCGCTGCTGGCCCGCAACGCCGTCGAAAAGGGACTGGCCTCCAAACCATGGGTGAAAACCACGATGGCGCCGGGCTCGCAGGTGGTCAACGACTACTACGACCGGTCCGGTCTGTGGCCGTATTTGGAAAAGCTCGGCTTCTATCTGGTCGGCTACGGCTGCACCACGTGTATTGGCAACTCTGGCCCACTTCCCGAGGAGATTTCGAAAGCGATCAACTACAACAACCTTTCGGTGACCGCTGTGTTGTCGGGCAACCGAAACTTCGAGGGTCGCATCAACCCCGATGTGAAGATGAACTACTTGGCCTCGCCACCACTAGTGATCGCCTACGCACTAGCCGGGACAATGGACTTCGACTTCGAGAGCCAGCCGTTGGACACAGATAAAAACGGCAAGGCCGTCTACTTGAAAGACATCTGGCCCTCGCAAAAAGACGTCACCGACACCATCGCCTCGGCAATCAATCAAGAGATGTTCACCAAGAACTATGCCGACGTTTTCAAGGGCGATGAACGCTGGCGCAACTTGCCAACACCGAGCGGCAATACCTTTGATTGGGAACAGAATTCGACGTATGTGCGCAAACCTCCTTACTTCGAGGGAATGTCCGTAGAGCCCAAGCCAGTGCGTAACATCACCGGCGCTCGAGTGCTAGCGCTGCTGGACGACTCAGTGACCACCGACCACATCTCCCCCGCCAGCACCATCAAGCCGGGTACCCCGGCAGCACAATACCTCGACACCCATGGCGTCGACCGCAAGGACTACAATTCCTTCGGGTCACGTCGCGGCAACCACGAAGTCATGATCCGTGGCACATTTGCCAACATCAGACTGCGCAATATGCTGCTGAACGGCGTTGCGGGCGGGTACACCCGCGACTTCACCAAACCCGGTGCTCCGCAGGCGTTCATCTACGACGCGGCACAAAACTATGCGGCAGAAAACATTCCGTTGGTGGTACTCAGCGGCAAGGAATATGGGTCCGGGTCATCGCGCGACTGGGCGGCCAAGGGCACGTTGCTGTTAGGAGTGCGTGCGGTGATCGCCGAGTCGTTCGAACGCATCCACCGCTCCAACTTGATTGGTATGGGTGTGATCCCGCTACAATTCCCGCAGGGCGAGTCGGCTTCGTCGCTCGGACTGGACGGTACCGAAGTGTTCGAGATCAACGGTATCGATGTGTTCAATAATGGCAAGACACCAAAAACTGTGCATGTCAAAGCCAGCAAGGCTAGCGGAACCACAGTGACGTTCGATGCGTTGGTGCGCATAGACACCCCCGGTGAGGCCGACTACTACCGCAACGGCGGAATTCTGCATTACGTGTTGCGCAACATACTGAAGTCAAACTAATCCAGTA

Protein Sequence 

>ML1814_Acn_protein
VAKIR_TRFQPATP_KSATTVTKSIVWTPSPIPRDFHTVSKYSPKTYYATKTARISPKITSKR_QTGIGRRNPASKSSTRRPVSSCRTSQACRVSSTWPPCGRPSGISAATRKKSTHWRGLTW_LTTQ_SPICLAAPTRSSAMLKSSTSATASVISSCAGDKERSTTSRWYHRAPALCTR_TSNIWLVS__LRRIPKEQ_WHTPTPA_APTRTPRWSTGSAS_AGA_VASKLRPPCWASRCRC_SRGWSASS_VVRFSQVLQPPTSY_LSPKCCAGTVLLASSSSSTARAWPRYRWPIAPLWAI_ALNSVPLQQFFRSTKRRLTTCGSPGARLSKLPWSRVTPKSKACGTTPRMSRRSPNTSN_TSPMWYRRSPDRNVRRTESAWRKPSPRSARKFLSMLTAVRSTTNIRSWTR_SRRHAQPATRGSCRSPTTMRW_CNLRPRMRTAE_ATRCASRRKNSVSSCSTTARW_SPRSHLAPTPPILRLCCVRRCWPATPSKRDWPPNHG_KPRWRRARRWSTTTTTGPVCGRIWKSSASIWSATAAPRVLATLAHFPRRFRKRSTTTTFR_PLCCRATETSRVASTPM_R_TTWPRHH__SPTH_PGQWTSTSRASRWTQIKTARPST_KTSGPRKKTSPTPSPRQSIKRCSPRTMPTFSRAMNAGATCQHRAAIPLIGNRIRRMCANLLTSRECP_SPSQCVTSPALEC_RCWTTQ_PPTTSPPPAPSSRVPRQHNTSTPMASTARTTIPSGHVAATTKS_SVAHLPTSDCAICC_TALRAGTPATSPNPVLRRRSSTTRHKTMRQKTFRWWYSAARNMGPGHRATGRPRARCC_ECVR_SPSRSNASTAPT_LVWV_SRYNSRRASRLRRSDWTVPKCSRSTVSMCSIMARHQKLCMSKPARLAEPQ_RSMRWCA_TPPVRPTTTATAEFCITCCATY_SQTNPV

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding Acn with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

36 show weak predicted evidence for PPIs

View all pooled AlphaFold results for Acn

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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