sppA
mL1839c
POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) (SIGNAL PEPTIDE PEPTIDASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2226943 – 2228751
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1839c_sppA_dna
TGCAAGCATGTCCGCCTTTCTGCCCCCTTTTCCTGGTATCGATGACGTGCGTGCCCTGGCCAACCGGGTTAACACGGCCCGTCACCATGGCATACCGAATGGTTGCGTGCTCGAAGTCAATCTGCGGTCGTTGCCGCCGGAAACGACCAGCTTTGACCCCTTCACAATTATCACTAGGGGTGGCCGACCGATGGCCCTGCGCGAGGCTGTCGCCGCGATTCACCGCGCCGCCGCCGACCCCCGGGTCGCCGGTATGATTGCCCGCGTTCAGCTTGGTGCGTCGCCGCCTGCGGCAGTGCAGGAACTGCGCGAAGCCGTCGCCACTTTCAGTGCGGTCAAGCCGTCACTGGCCTGGGCCGAGACTTATCCTGGCACGCTGTCCTACTACCTGGCTTCGGCCTTTGGTGAGGTCTGGATGCAGCCGTCGGGTAGTGTCGGGCTGGTCGGCTTCGCTAGCAATGCCACGTTTCTACGCGACGTGCTGGCCAAGGTAGGGATCGAAGCGCAGTTCGTCGCACGGGGTGAATACAAGTCAGCGGCAAACCTTTTCACCGAAGGCGGCTTCACCGACGCTCACCGCGAGGCGGTCAGCCGAATGCTGGAAAGTCTGCAAGGCCAGGTGTGGCAGGGGATCGCCGAATCACGCAGGATCGATCCCGCAGCGCTCAATCCGTTGGCCGACCGGGCTCCTCTGTTACGCGATGACGCGGTCGCTTCCGGTTTGGTCGACCGTATTGGATTCCGCGACGAAGCTTATGCTCGTATAGCGGAACTTGTTGGTGCTGAAAGTATTACACCAAATTCAAGCGAGCCGCAGGCGAGAACAGAGGCCAACGACGGTCTACCGCGACTGTATTTGTCGCGCTACGCTAGTGCGGGCCGGTCACGGTTGATGCCCCCCATGCCGTTGATTCCCGGACGCCGATCCAAGCCAACGGTTGTCGTGGTCACTCTGGAAGGTCCGATTGTCAACGGGCGCGGTGGACCGCAGTTTCTGCCGTTCGGTATCTCTACCGGCGGTGGTGACACCATTGCGGCGGCGCTCCGCGAGGTCGCTGCCGACGATTCAGTGTCCGCGATTGTGCTGCGGGTGAACAGCCCGGGTGGCTCGGTTACCGCATCTGAAACCATCTGGCGTGAGGTGAAAAGGGCCCGCGATCGCGGCAAGCCGGTAGTGGTTTCCATGGGGGCGGTAGCTGCCTCTGGCGGCTACTACGTCTCGGTGGGCGCTGACGAGATTGTGGCCAATCCCGGTACGATCACCGGTTCGATTGGCGTGATCACCGGGAAGCTGGTGATTCGGGACCTGAAAGGTCGGTTGGGCGTTGGGTCAGATACGGTGCGCACCAACGCCAATGCTGATGCGTGGTCGGCTAACGTGCCGTTCACGCCGGAGCAGCACACCCATCGAGAGGCCGAGGCGGACCTGTGCTATGCTGACTTTCTTGAACGCGTAGCAGAAGGCCGCGGCATGACCACTGATGCAGTGGATGATGTTGCGCGAGGGCGGATTTGGACTGGTGCCGATGCTCTCGAACGCGGTCTGGTCGACGAACTCGGCGGGCTTGTAACCGCGGTGCGCAGAGCCAAGGTCCTAGCCGGTTTGGATGCGGACGTCGATGTCCGCATCGTCAGTTACCCCGGCTCGTCGTTGCTGGACATGGTACGACCCCGTGCGTCGTCGCAACCCGGGGCTGCGTCGTTGCCAGACGCGGTAGCCACGCTGCTAGGACGCTCGGTTGCCGGGATACTCGAACAGGTCGAGCAAGCGTTAAGCGGTGTCAGAGTGCTGTGGTTGGGGGAGTACCG

Protein Sequence 

>ML1839c_SppA_protein
CKHVRLSAPFSWYR_RACPGQPG_HGPSPWHTEWLRARSQSAVVAAGNDQL_PLHNYH_GWPTDGPARGCRRDSPRRRRPPGRRYDCPRSAWCVAACGSAGTARSRRHFQCGQAVTGLGRDLSWHAVLLPGFGLW_GLDAAVG_CRAGRLR_QCHVSTRRAGQGRDRSAVRRTG_IQVSGKPFHRRRLHRRSPRGGQPNAGKSARPGVAGDRRITQDRSRSAQSVGRPGSSVTR_RGRFRFGRPYWIPRRSLCSYSGTCWC_KYYTKFKRAAGENRGQRRSTATVFVALR_CGPVTVDAPHAVDSRTPIQANGCRGHSGRSDCQRARWTAVSAVRYLYRRW_HHCGGAPRGRCRRFSVRDCAAGEQPGWLGYRI_NHLA_GEKGPRSRQAGSGFHGGGSCLWRLLRLGGR_RDCGQSRYDHRFDWRDHREAGDSGPERSVGRWVRYGAHQRQC_CVVG_RAVHAGAAHPSRGRGGPVLC_LS_TRSRRPRHDH_CSG_CCARADLDWCRCSRTRSGRRTRRACNRGAQSQGPSRFGCGRRCPHRQLPRLVVAGHGTTPCVVATRGCVVARRGSHAARTLGCRDTRTGRASVKRCQSAVVGGVP

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding SppA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

6 show weak predicted evidence for PPIs

View all pooled AlphaFold results for SppA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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