rpoC
mL1890c
DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT).
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2269277 – 2273227
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1890c_rpoC_dna
GAGTTACGTGCTAGACGTCAACTTCTTCGATGAACTCCGCATTGGCCTGGCTACCGCGGAGGACATTCGTCAATGGTCTTACGGCGAGGTTAAGAAGCCAGAGACCATCAACTATCGTACGCTCAAACCTGAGAAGGATGGCCTGTTCTGTGAGAAGATCTTCGGACCTACTCGCGACTGGGAGTGCTACTGCGGCAAATACAAGCGGGTGCGTTTCAAGGGTATCATCTGTGAGCGTTGTGGCGTCGAGGTGACTCGCGCCAAGGTGCGTCGTGAGCGGATGGGCCATATCGAGCTGGCCGCACCTGTCACGCACATCTGGTACTTCAAAGGTGTACCGTCGCGCCTGGGCTATCTGCTCGACCTGGCCCCGAAGGACCTTGAGAAGATTATCTACTTCGCCGCGTACGTGATCACCACGGTCGATGAGGAGATGCGGCACAACGAGCTGTCGACGCTCGAGGCTGAAATGATGGTGGAGCGCAAGTCTGTTGAGGATCAGCGCGATGCCGACCTGGAAGCTCGTGCTCAGAAATTAGAGGCCGACTTGGCTGCGCTGGAGGCTGAGGGTGCCAAGGCAGACGCCAGGCGTAAGTTCCGGGATGGCGGTGAGCGCGAGATGCGCCAGCTCCGTGAGCGTGCGCAGCGTGAGCTGGATCGTTTAGAAGATATCTGGAGCACCTTTACCAAGCTGGCTCCCAAGCAGCTGATCGTTGACGAAAATCTCTATCGTGAATTGGTCGACCGTTATGGCGAATACTTCACTGGCGCCATGGGTGCGGAGTCTATTCAGAAGTTGATGCAGGACTTTGACATCGAGGCCGAGGCTGAGTCGCTGCGTGAAGTGATTCGAAACGGTAAGGGGCAAAAGAAGCTTCGGGCGCTAAAGCGACTGAAGGTAGTCGCTGCCTTCCAACAGTCAGGCAACTCGCCAATGGGCATGGTGCTCGACGCTGTCCCGGTCATACCGCCGGAACTGCGCCCGATGGTGCAGCTCGACGGTGGCCGGTTTGCCACGTCCGACTTGAACGACCTGTACCGCCGGGTGATCAACCGTAACAACCGGCTGAAAAGGTTAATCGATCTGGGTGCGCCCGATATCATTGTCAACAACGAGAAGCGGATGCTGCAGGAGTCTGTGGACGCGCTGTTCGACAATGGACGCCGGGGAAGACCTGTTACGGGGCCGGGCAACCGTCCACTGAAGTCGCTGTCTGATCTGCTCAAGGGCAAGCAAGGCCGGTTTCGGCAGAACCTGCTTGGTAAGCGTGTTGATTACTCGGGCCGTAGCGTCATCGTGGTCGGCCCGCAGCTCAAGTTGCACCAGTGTGGATTGCCCAAGCTGATGGCGCTGGAGCTGTTCAAGCCGTTCGTGATGAAGCGGTTGGTTGATCTCAATCACGCGCAAAACATCAAGAGCGCCAAGCGAATGGTGGAGCGGCAGCGGCCTCAGGTGTGGGATGTGCTCGAAGAGGTCATCGCGGAGCATCCGGTGCTGCTGAACCGTGCGCCCACCCTGCACCGACTGGGTATCCAAGCTTTCGAGCCGATGCTTGTGGAAGGCAAGGCTATTCAGCTGCATCCGTTGGTGTGTGAGGCGTTCAACGCCGACTTCGACGGTGATCAGATGGCGGTGCATCTGCCTCTGAGTGCCGAAGCGCAGGCCGAGGCCCGCATTCTGATGCTGTCGAGTAACAACATCTTGTCACCCGCCTCCGGCCGCCCACTGGCTATGCCGCGACTGGACATGGTGACTGGACTATATTACCTTACCACCGCGGTCGACGGCGACACTGGCGCCTACCGGCCGGCAGCCGAGGATCGTCCAGAGTCGGGTGTGTACTCTTCTCCGGCCGAAGCGATTATGGCGGCCGACCGCGGGGTGCTTTCGGTGCGGGCTAAGATCAAAGTCCAGTTAACTCAGGTGCGTCCGCCGGCCGACATCGAGGCTAGATGGTTCGGCGCCAATGGTTGGCGTCCAGGAGATCCGTGGATAGCCGATACCACGCTGGGTCGGGTGATGTTCAACGAACTACTGCCGCTGGGCTATCCGTTTGTTAACAAGCAGATGCATAAGAAAGTGCAGGCCGCTATCATCAACGACTTAGCCGAGCGCTACCCGATGATAGTCGTCGCGCAGACTGTCGACAAGCTCAAGGACGCCGGTTTCTACTGGGCGACCCGCAGCGGCGTTACGGTCTCGATGGCTGACGTGTTGGTTCCGCCGCGTAAGAAGGAGATCCTCGACCACTACGAGGAGCGTGCCGACAAAGTCGAAAAGCAGTTCCAACGTGGCGCTTTGAACCACGACGAACGCAATGAGGCGCTGGTGGAGATCTGGAAAGAAGCCACCGACGAGGTCGGTCAGGCGCTGCGGGACCACTACCCGGTCGACAACCCGATCATCACAATCGTTGATTCCGGTGCCACGGGTAACTTCACCCAAACCCGGGCGCTGGCCGGCATGAAGGGTTTGGTGACCAACCCTAAGGGTGAGTTCATTCCGCGCCCGGTCAAGTCATCGTTCCGCGAGGGTCTGACTGTGTTGGAGTACTTCATCAACACCCATGGTGCTCGAAAGGGCTTGGCTGACACCGCGTTGCGTACCGCCGACTCGGGGTACCTGACCCGTCGTCTGGTGGACGTGTCGCAAGACGTCATCGTCCGCGAACACGACTGCCAGACTGAGCGCGGCATTGTCGTTGAGCTGGCCGTGCGTGTGCCCGATGGCAGCCTGATCCGCGAGCTGTACATCGAAACGTCGGCATACGCAAGGACTTTGGGCGCCAACGCGGTCGACGAAGCTGGCAACGTGATCGTCGCGCGTGGTGAGGACCTGGGTGACCCGGAGATCGATGCCTTGCTGGCGGCGGGCATCACGCAGGTCAAGGTGCGCTCAGTGCTGACCTGTACCACCGGCACCGGTGTATGCGCTACATGCTACGGGCGTTCGATGGCTACCGGCAAGCTGGTCGACATCGGTGAGGCCGTCGGTATTGTCGCGGCCCAGTCCATCGGTGAGCCCGGCACGCAGCTGACCATGCGTACCTTCCACCAAGGCGGTGTCGGTGAGGACATCACCGGTGGTTTGCCTCGGGTTCAGGAGCTGTTCGAGGCCCGGGTGCCGCGTGGCAAGGCGCCGATTGCCGACGTTACTGGGCGAGTCCGTCTCGAGGACGGTGAACGCTTCTACAAGATCACTATTGTTCCCGACGACGGTGGAGAAGAAGTCGTCTACGATAAGCTTTCCAAGCGCCAACGGCTGCGGGTGTTCAAGCACGCAGACGGTTCCGAGCGAGTGCTTTCCGACGGTGACTACGTCGAGGTGGGTCAGCAGTTGATGGAAGGTTCCGCTGACCCGCACGAGGTGCTGCGCGTGCAAGGCCCTCGCGAGGTGCAGATCCATCTGGTGCGCGAGGTTCAAGAGGTGTACCGTGCGCAGGGTGTGTCGATCCACGACAAGCACATCGAGGTGATCGTTCGCCAGATGCTGCGCCGGGTCACCATCATCGACTCGGGTTCGACGGAATTCCTGCCCGGCTCGTTGATCGACCGTGCGGAGTTCGAGTCGGAGAATCGTCGGGTGGTGGCCGAGAGTGGCGAGCCCGCTGCCGGCCGTCCGGTGCTGATGGGTATCACCAAGGCGTCGTTGGCCACCGACTCGTGGTTGTCTGCGGCGTCGTTCCAGGAGACGACGCGGGTGTTGACCGATGCGGCGATCAACTGCCGCAGCGATAAGCTCAACGGTCTTAAGGAGAACGTGATCATCGGAAAGTTGATCCCGGCCGGTACCGGTATTAACCGGTACCGCAACATCCAGGTGCAGCCCACCGAGGAGGCCCGCGCCTCGGCGTACACGATTCCATCCTACGAGGATCAGTACTACAGTCCGGACTTCGGCCAGGCCACCGGTGCTGCCGTTCCACTGGACGACTACGGCTACAGCGACTA

Protein Sequence 

>ML1890c_RpoC_protein
ELRARRQLLR_TPHWPGYRGGHSSMVLRRG_EARDHQLSYAQT_EGWPVL_EDLRTYSRLGVLLRQIQAGAFQGYHL_ALWRRGDSRQGAS_ADGPYRAGRTCHAHLVLQRCTVAPGLSARPGPEGP_EDYLLRRVRDHHGR_GDAAQRAVDARG_NDGGAQVC_GSARCRPGSSCSEIRGRLGCAGG_GCQGRRQA_VPGWR_ARDAPAP_ACAA_AGSFRRYLEHLYQAGSQAADR_RKSLS_IGRPLWRILHWRHGCGVYSEVDAGL_HRGRG_VAA_SDSKR_GAKEASGAKATEGSRCLPTVRQLANGHGARRCPGHTAGTAPDGAARRWPVCHVRLERPVPPGDQP_QPAEKVNRSGCARYHCQQREADAAGVCGRAVRQWTPGKTCYGAGQPSTEVAV_SAQGQARPVSAEPAW_AC_LLGP_RHRGRPAAQVAPVWIAQADGAGAVQAVRDEAVG_SQSRAKHQERQANGGAAAASGVGCARRGHRGASGAAEPCAHPAPTGYPSFRADACGRQGYSAASVGV_GVQRRLRR_SDGGASASECRSAGRGPHSDAVE_QHLVTRLRPPTGYAATGHGDWTILPYHRGRRRHWRLPAGSRGSSRVGCVLFSGRSDYGGRPRGAFGAG_DQSPVNSGASAGRHRG_MVRRQWLASRRSVDSRYHAGSGDVQRTTAAGLSVC_QADA_ESAGRYHQRLSRALPDDSRRADCRQAQGRRFLLGDPQRRYGLDG_RVGSAA_EGDPRPLRGACRQSRKAVPTWRFEPRRTQ_GAGGDLERSHRRGRSGAAGPLPGRQPDHHNR_FRCHG_LHPNPGAGRHEGFGDQP_G_VHSAPGQVIVPRGSDCVGVLHQHPWCSKGLG_HRVAYRRLGVPDPSSGGRVARRHRPRTRLPD_ARHCR_AGRACARWQPDPRAVHRNVGIRKDFGRQRGRRSWQRDRRAW_GPG_PGDRCLAGGGHHAGQGALSADLYHRHRCMRYMLRAFDGYRQAGRHR_GRRYCRGPVHR_ARHAADHAYLPPRRCR_GHHRWFASGSGAVRGPGAAWQGADCRRYWASPSRGR_TLLQDHYCSRRRWRRSRLR_AFQAPTAAGVQARRRFRASAFRR_LRRGGSAVDGRFR_PARGAARARPSRGADPSGARGSRGVPCAGCVDPRQAHRGDRSPDAAPGHHHRLGFDGIPARLVDRPCGVRVGESSGGGREWRARCRPSGADGYHQGVVGHRLVVVCGVVPGDDAGVDRCGDQLPQR_AQRS_GERDHRKVDPGRYRY_PVPQHPGAAHRGGPRLGVHDSILRGSVLQSGLRPGHRCCRSTGRLRLQRL

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding RpoC with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

12 proteins show strong predicted evidence for PPIs

36 show intermediate predicted evidence for PPIs

120 show weak predicted evidence for PPIs

View all pooled AlphaFold results for RpoC

Use of these data is subject to the AlphaFold Server Output Terms of Use.

You do not have permission to view notes.