rpoB
mL1891c
DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2273276 – 2276812
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1891c_rpoB_dna
GCACGAGGTGCTGGAAGGATGCATCTTGCCAGATTTCGGCCAGAGCAAGACAGACGTTAGTCCTAGCCAGAGTCGCCCCCAAAGTTCGCCCAACAACTCCGTGCCCGGCGCGCCCAACCGAATTTCATTTGCCAAGCTCCGCGAACCGCTTGAGGTTCCGGGGCTACTTGATGTGCAGACTGATTCATTTGAGTGGTTGATCGGATCGCCGTGCTGGCGTGCAGCGGCCGCAAGCCGCGGCGATCTCAAGCCGGTGGGTGGTCTCGAAGAGGTGCTCTACGAGCTGTCGCCGATCGAGGATTTCTCCGGCTCAATGTCATTGTCTTTCTCCGATCCCCGTTTTGACGAAGTCAAGGCGCCCGTCGAAGAGTGCAAAGACAAGGACATGACGTACGCGGCCCCGCTGTTCGTCACGGCCGAGTTCATCAACAACAACACCGGGGAGATCAAGAGCCAGACGGTGTTTATGGGCGACTTCCCTATGATGACTGAGAAGGGAACCTTCATCATCAACGGGACCGAGCGTGTCGTCGTTAGCCAGCTGGTGCGCTCCCCTGGAGTATACTTCGACGAGACGATCGACAAGTCCACAGAAAAGACGCTGCATAGTGTCAAGGTGATTCCCAGCCGCGGTGCCTGGTTGGAATTCGATGTCGATAAACGCGACACCGTCGGTGTCCGCATTGACCGGAAGCGCCGGCAACCCGTCACGGTGCTTCTCAAAGCGCTAGGTTGGACCAGTGAGCAGATCACCGAGCGTTTCGGTTTCTCCGAGATCATGCGCTCGACGCTGGAGAAGGACAACACAGTTGGCACCGACGAGGCGCTGCTAGACATCTATCGTAAGTTGCGCCCAGGTGAGCCGCCGACTAAGGAGTCCGCGCAGACGCTGTTGGAGAACCTGTTCTTCAAGGAGAAACGCTACGACCTGGCCAGGGTTGGTCGTTACAAGGTCAACAAGAAGCTCGGGTTGCACGCCGGTGAGTTGATCACGTCGTCCACGCTGACCGAAGAGGATGTCGTCGCCACCATAGAGTACCTGGTTCGTCTGCATGAGGGTCAGTCGACAATGACTGTCCCAGGTGGGGTAGAAGTGCCAGTGGAAACTGACGATATCGACCACTTCGGCAACCGCCGGCTGCGCACGGTCGGCGAATTGATCCAGAACCAGATCCGGGTCGGTATGTCGCGGATGGAGCGGGTGGTCCGGGAGCGGATGACCACCCAGGACGTCGAGGCGATCACGCCGCAGACGCTGATCAATATCCGTCCGGTGGTCGCCGCTATCAAGGAATTCTTCGGCACCAGCCAGCTGTCGCAGTTCATGGATCAGAACAACCCTCTGTCGGGCCTGACCCACAAGCGCCGGCTGTCGGCGCTGGGCCCGGGTGGTTTGTCGCGTGAGCGTGCCGGGCTAGAGGTCCGTGACGTGCACCCTTCGCACTACGGCCGGATGTGCCCGATCGAGACTCCGGAGGGCCCGAACATAGGTCTGATCGGTTCATTGTCGGTGTACGCGCGGGTCAACCCCTTCGGGTTCATCGAAACACCGTACCGCAAAGTGGTTGACGGTGTGGTCAGCGACGAGATCGAATACTTGACCGCTGACGAGGAAGACCGCCATGTCGTGGCGCAGGCCAACTCGCCGATCGACGAGGCCGGCCGCTTCCTCGAGCCGCGCGTGTTGGTGCGCCGCAAGGCGGGCGAGGTGGAGTACGTGGCCTCGTCCGAGGTGGATTACATGGATGTCTCGCCACGCCAGATGGTGTCGGTGGCCACAGCGATGATTCCGTTCCTTGAGCACGACGACGCCAACCGTGCCCTGATGGGCGCTAACATGCAGCGCCAAGCGGTTCCGTTGGTGCGCAGCGAAGCACCGTTGGTGGGTACCGGTATGGAGTTGCGCGCGGCCATCGACGCTGGCCACGTCGTCGTTGCGGAGAAGTCCGGGGTGATCGAGGAGGTTTCCGCCGACTACATCACCGTGATGGCCGATGACGGCACCCGGCGGACTTATCGGATGCGTAAGTTCGCGCGCTCCAACCACGGCACCTGCGCCAACCAGTCCCCGATCGTGGATGCGGGGGATCGGGTCGAGGCCGGCCAAGTGATTGCTGACGGTCCGTGCACTGAGAACGGCGAGATGGCGTTGGGCAAGAACTTGCTGGTGGCGATCATGCCGTGGGAGGGTCACAACTACGAGGATGCGATCATCCTGTCTAACCGACTGGTCGAAGAGGACGTGCTTACTTCGATTCACATTGAGGAGCATGAGATCGACGCCCGTGACACCAAGCTGGGTGCTGAGGAGATCACCCGGGACATTCCCAACGTCTCCGATGAGGTGCTAGCCGACTTGGACGAGCGGGGCATCGTGCGGATTGGCGCGGAGGTTCGTGACGGTGATATCCTGGTTGGCAAGGTCACCCCGAAGGGGGAAACTGAGCTGACACCGGAAGAGCGGTTGCTGCGGGCGATCTTCGGCGAAAAGGCCCGCGAGGTCCGTGACACGTCGCTGAAGGTGCCACACGGCGAATCCGGCAAGGTGATCGGCATTCGGGTGTTCTCCCATGAGGATGACGACGAGCTGCCCGCCGGCGTCAACGAGCTGGTCCGTGTCTACGTAGCCCAGAAGCGCAAGATCTCTGACGGTGACAAGCTGGCTGGGCGGCACGGCAACAAGGGCGTGATCGGCAAGATCCTGCCTGCCGAGGATATGCCGTTTCTGCCAGACGGCACCCCGGTGGACATCATCCTCAACACTCACGGGGTGCCGCGGCGGATGAACGTCGGTCAGATCTTGGAAACCCACCTTGGGTGGGTAGCCAAGTCCGGCTGGAAGATCGACGTGGCCGGCGGTATACCGGATTGGGCGGTCAACTTGCCTGAGGAGTTGTTGCACGCTGCGCCCAACCAGATCGTGTCGACCCCGGTGTTCGACGGCGCCAAGGAAGAGGAACTACAGGGCCTGTTGTCCTCCACGTTGCCCAACCGCGACGGCGATGTGATGGTGGGCGGCGACGGCAAGGCGGTGCTCTTCGATGGGCGCAGCGGTGAGCCGTTCCCTTATCCGGTGACGGTTGGCTACATGTACATCATGAAGCTGCACCACTTGGTGGACGACAAGATCCACGCCCGCTCCACCGGCCCGTACTCGATGATTACCCAGCAGCCGTTGGGTGGTAAGGCACAGTTCGGTGGCCAGCGATTCGGTGAGATGGAGTGCTGGGCCATGCAGGCCTACGGTGCGGCCTACACGCTGCAGGAGCTGTTGACCATCAAGTCCGACGACACCGTCGGTCGGGTCAAGGTTTACGAGGCTATCGTTAAGGGTGAGAACATCCCCGAGCCGGGCATCCCCGAGTCGTTCAAGGTGCTGCTCAAGGAGTTACAGTCGCTGTGTCTCAACGTCGAGGTGCTGTCGTCCGACGGTGCGGCGATCGAGTTGCGCGAAGGTGAGGATGAGGACCTCGAGCGGGCTGCGGCCAACCTCGGTATCAACTTGTCCCGCAACGAATCGGCGTCCATAGAAGATCT

Protein Sequence 

>ML1891c_RpoB_protein
ARGAGRMHLARFRPEQDRR_S_PESPPKFAQQLRARRAQPNFICQAPRTA_GSGAT_CAD_FI_VVDRIAVLACSGRKPRRSQAGGWSRRGALRAVADRGFLRLNVIVFLRSPF_RSQGARRRVQRQGHDVRGPAVRHGRVHQQQHRGDQEPDGVYGRLPYDD_EGNLHHQRDRACRR_PAGALPWSILRRDDRQVHRKDAA_CQGDSQPRCLVGIRCR_TRHRRCPH_PEAPATRHGASQSARLDQ_ADHRAFRFLRDHALDAGEGQHSWHRRGAARHLS_VAPR_AAD_GVRADAVGEPVLQGETLRPGQGWSLQGQQEARVARR_VDHVVHADRRGCRRHHRVPGSSA_GSVDNDCPRWGRSASGN_RYRPLRQPPAAHGRRIDPEPDPGRYVADGAGGPGADDHPGRRGDHAADADQYPSGGRRYQGILRHQPAVAVHGSEQPSVGPDPQAPAVGAGPGWFVA_ACRARGP_RAPFALRPDVPDRDSGGPEHRSDRFIVGVRAGQPLRVHRNTVPQSG_RCGQRRDRILDR_RGRPPCRGAGQLADRRGRPLPRAARVGAPQGGRGGVRGLVRGGLHGCLATPDGVGGHSDDSVP_ARRRQPCPDGR_HAAPSGSVGAQRSTVGGYRYGVARGHRRWPRRRCGEVRGDRGGFRRLHHRDGR_RHPADLSDA_VRALQPRHLRQPVPDRGCGGSGRGRPSDC_RSVH_ERRDGVGQELAGGDHAVGGSQLRGCDHPV_PTGRRGRAYFDSH_GA_DRRP_HQAGC_GDHPGHSQRLR_GASRLGRAGHRADWRGGS_R_YPGWQGHPEGGN_ADTGRAVAAGDLRRKGPRGP_HVAEGATRRIRQGDRHSGVLP_G_RRAARRRQRAGPCLRSPEAQDL_R_QAGWAARQQGRDRQDPACRGYAVSARRHPGGHHPQHSRGAAADERRSDLGNPPWVGSQVRLEDRRGRRYTGLGGQLA_GVVARCAQPDRVDPGVRRRQGRGTTGPVVLHVAQPRRRCDGGRRRQGGALRWAQR_AVPLSGDGWLHVHHEAAPLGGRQDPRPLHRPVLDDYPAAVGW_GTVRWPAIR_DGVLGHAGLRCGLHAAGAVDHQVRRHRRSGQGLRGYR_G_EHPRAGHPRVVQGAAQGVTVAVSQRRGAVVRRCGDRVARR_G_GPRAGCGQPRYQLVPQRIGVHRRS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding RpoB with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

12 proteins show strong predicted evidence for PPIs

30 show intermediate predicted evidence for PPIs

139 show weak predicted evidence for PPIs

View all pooled AlphaFold results for RpoB

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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