fum
mL1947
PROBABLE FUMARASE FUM (Fumarate hydratase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2333631 – 2335055
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1947_fum_dna
GGACCCAATTCATGGCCGACAGCGCCGAATACCGCATCGAGCACGACACCATGGGCGAAGTCCGGGTACCGGCAATAGCATTGTGGCGCGCGCAAACCCAGCGCGCGGTGGAGAACTTCCCAATCTCCGGTCGAGGTTTAGAGCGCACCCAAATCCGAGCGTTGGGTCTGCTGAAAGGCGCTTGCGCGCAGGTCAACAAAGACCTGGGATTGTTGGCTTCGGAGAAAGCCAACGCAATCATTGCCGCGGCGGCCACAATCGCCGACGGCTACCACGACGACCAATTCCCGATTGACGTATTCCAAACCGGATCCGGCACCAGCTCCAACATGAACACCAACGAGGTTATCGGCAGCATCGCGGCAGCCAACGGTGTACCGGTGCATCCCAACGACGACGTCAACATGTCGCAATCATCCAACGACACATTCCCGACCGCTACCCACATCGCAGCCACCGAAGCCGCGGTACGCCATCTGATTCCGGCGCTGCAAGAGCTGCACGCCGCACTGGCGACCAAGTCCAGCGAGTGGCACACGGTGGTGAAATCGGGTCGCACGCACTTGATGGACGCCGTTCCGGTAACACTCGGCCAGGAGTTCGGTGGATACGCTCGCCAAATCGAGGCCGGAATCGAGCGCGTACGCGCCACGCTGCCACGGCTTGGTGAACTGGCAATCGGCGGCACCGCAGTAGGCACCGGCCTCAACGCTCCCGATGGCTTCGGCGCTAAGGTGGTCGAGGCACTGATCGCTACCACGGGTCTGACCGAACTACGACCGGCAGCAAACTCATTCGAGGCACAGGCCGCCCGAGACGGGCTTGTAGAGGCATCCGGGGCGCTGCGCACTATCGCGGTGTCACTGACTAAGATTGCCAACGATATTCGGTTGATGGGATCCGGTCCGCTGACCGGCCTGGCGGAGATCCAGCTGCCAGACTTACAGCCGGGTAGCTCGATCATGCCAGGCAAGGTAAATCCGGTTCTTCCGGAGGCGGTTACCCAGGTTGCCGCGCAGGTGATTGGCAATGATGCCGCCGTTGCCTGGGGCGGTGCAAATGGAGCCTTTGAGCTCAACGTCTATATCCCGATGATGGCCCGCAACATCTTGGAGTCGTACCAGCTGCTAACCAACGTGTCCAGGCTGTTTGCGGAGCGTTGTATTAAAGGGCTTTCCGCCAATATCGAGCACCTGCGCGAGCTGGCCGAGTCGTCGCAGTCGATCGTGACACCCTTGAATTCGGCCATCGGATACGAGGAGGCTGCCGCGGTGGTCAAACAAGCACTCAAGGAACGCAAGACCCTCCGTCAGACCGTTATCGACCGCGGCTTGATCGGGGACAAGCTGTCCCTCGAGGAGCTGGACCGCCGACTTGATGTGCTGGCGATGGCAAAAGTCAAGCCAGCGGATTCCTAACCGAATT

Protein Sequence 

>ML1947_Fum_protein
GPNSWPTAPNTASSTTPWAKSGYRQ_HCGARKPSARWRTSQSPVEV_SAPKSERWVC_KALARRSTKTWDCWLRRKPTQSLPRRPQSPTATTTTNSRLTYSKPDPAPAPT_TPTRLSAASRQPTVYRCIPTTTSTCRNHPTTHSRPLPTSQPPKPRYAI_FRRCKSCTPHWRPSPASGTRW_NRVART_WTPFR_HSARSSVDTLAKSRPESSAYAPRCHGLVNWQSAAPQ_APASTLPMASALRWSRH_SLPRV_PNYDRQQTHSRHRPPETGL_RHPGRCALSRCH_LRLPTIFG_WDPVR_PAWRRSSCQTYSRVARSCQAR_IRFFRRRLPRLPRR_LAMMPPLPGAVQMEPLSSTSISR_WPATSWSRTSC_PTCPGCLRSVVLKGFPPISSTCASWPSRRSRS_HP_IRPSDTRRLPRWSNKHSRNARPSVRPLSTAA_SGTSCPSRSWTADLMCWRWQKSSQRIPNRI

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding Fum with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

1 shows weak predicted evidence for PPIs

View all pooled AlphaFold results for Fum

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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