rpoA
mL1957c
PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2344713 – 2345756
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1957c_rpoA_dna
GAACCTGATGCTGATTTCACAACGCCCCACCTTGTCCGAGGACATCCTTACCGACAACCGGTCCCAGTTCGTCATCGAACCGTTGGAGCCGGGATTCGGTTATACCCTGGGCAACTCGCTGCGGCGCACGCTGCTGTCGTCGATTCCCGGAGCGGCCGTTACCAGCATTCGTATCGACGGCGTCTTGCACGAGTTCACCACGGTGCCTGGGGTTAAGGAGGATGTCACTGAGATCATCCTGAACCTCAAGGGTCTGGTGGTGTCCTCGGAGGAGGACGAACCGGTCACGATGTACCTGCGCAAGCAGGGTCCTGGTGAGGTCACTGCCGGTGATATCGTGCCGCCGGCCGGCGTCACCCTGCACAATCCTGGTATGCGCATCGCGACGCTAAACGACAAAGGTAAGATCGAAGCGGAGCTCGTTGTCGAGCGTGGCCGCGGTTACGTGCCGGCGGTGCAAAATCGGGCTTTGGGTGCCGAAATCGGACGCATCCCAGTCGATTCCATCTACTCACCGGTGCTGAAGGTAACATACAAGGTGGATGCCACTCGGGTGGAGCAGCGGACCGACTTCGACAAGCTGATCCTCGACGTGGAGACCAAGAGTTCGATCACCCCTCGCGACGCACTAGCGTCAGCGGGTAAGACGCTGGTCGAGTTGTTCGGTCTGGCACGCGAGCTCAATGTCGAGGCCGAAGGAATTGAGATCGGGCCGTCTCCGGCCGAGGCCGACCACATCGCGTCGTTCGCGCTGCCGATCGACGACCTGGATCTAACCGTGCGGTCCTACAACTGCCTCAAGCGCGAGGGTGTGCACACCGTTGGCGAGCTGGTGTCGCGTACCGAGTCCGACCTGCTCGACATCCGCAACTTTGGGCAGAAGTCCATCGACGAGGTGAAGGTCAAACTGCACCAACTGGGTCTGTCGCTCAAGGACAGCCCGGACAGTTTCGACCCGTCCGAGGTCGCCGGATACGACGTCACCACCGGCACGTGGTCCACCGACGGCGCCTACGACAGCCAGGACTACGCCGAAACCGAACA

Protein Sequence 

>ML1957c_RpoA_protein
EPDADFTTPHLVRGHPYRQPVPVRHRTVGAGIRLYPGQLAAAHAAVVDSRSGRYQHSYRRRLARVHHGAWG_GGCH_DHPEPQGSGGVLGGGRTGHDVPAQAGSW_GHCR_YRAAGRRHPAQSWYAHRDAKRQR_DRSGARCRAWPRLRAGGAKSGFGCRNRTHPSRFHLLTGAEGNIQGGCHSGGAADRLRQADPRRGDQEFDHPSRRTSVSG_DAGRVVRSGTRAQCRGRRN_DRAVSGRGRPHRVVRAADRRPGSNRAVLQLPQARGCAHRWRAGVAYRVRPARHPQLWAEVHRRGEGQTAPTGSVAQGQPGQFRPVRGRRIRRHHRHVVHRRRLRQPGLRRNRT

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding RpoA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

46 show weak predicted evidence for PPIs

View all pooled AlphaFold results for RpoA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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