aceA
mL1985c
PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2369809 – 2372205
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1985c_aceA_dna
ATGTCGATTGGCAGGCATACCGGCCACGGTCGTCCAGCGATGTAACTCAACTAACCTGGACGATAGACTACACTACTCTCCGTTAGGGGACCGGGCTAAGGAGGAGCGCAATCCCATGGCCATCATGGACACGAACACCGAGGTCCACACACTGTTTACGCAGGAAGTCGCCGCAACGCAGCAATACTTTGACGACCCACGGTTTGCCGGGATTATTCGCCTTTATACAGCCCGCCAGGTCGTAGAACAACGCGGCACCATCCCCACCGATTACACCGTGGCACGAGACGCCGCGACAGCTTTCTACGCTCGCTTGCGCGAGCTATTCGCGGCCGGCAAGAGCGTTACGACGTTCGGCCCCTATTCGCCAGGGCAAGCAGTCAGCCTTAAGCGGATGGGCATCGAGGCGATCTATCTAGGCGGCTGGGCAACCTCAGCTAAGGGTTCCATCACCGAAGATCCCGGTCCTGATCTCGCCAGCTACCCCCTGAGCCAGGTGCCAGATGATGCCGCGGTACTGGTGCGCGCCCTGCTGGCTGCTGACCGCAATCAGCAGTACCTGCGGTTACACATGACTGAACAGCAGCGTGCCGCCACTCCGGCGTATGACTACCGCCCATTCATCATCGCCGACGCCGACACGGGACATGGCGGTGACTCGCACGTACGCAACCTGATCCGCCGATTTGTTGAGATCGGCGTTCCAGGATACCACATCGAGGACCAGCGCCCGGGTACCAAGAAGTGTGGCCATCAGGGCGGGAAGGTTCTAGTGCCTTCGGACGAACAAATCAAGCGCCTCAACGCCGCCCGCTTCCAGCTCGACATTATGCGGGTGCCCGGCATCATCGTCGCGCGTACAGATGCCGAGGCGGCCAACTTGATCGACAGTCGCGCCGATGAGCGAGACCAGCCGTTCTTGCTGGGCGCCACCAATCTGAAGATTCCTTCTTACAAGGCTTGTTTCCTGGCGTTGGTGCGGTGTTTCTACGAGCTGGGAGTTAAGGAACTCCATGGCCATCTCCTCTACGCGTTAGGCGATGGCGAATATGCTGCTGCGAGCGCGTGGCTTGATCGCCAAGGGATTCTGGCCCAGGTCTCCGGTACCGTCAATGCTTGGCAGGAAAACGGAAAGCAATCGATCGACGATCTCTTCGAACAAGTTGAATATCGGTTATTGGCCGCTTGGGAGAAGGACGCCGGGCTGATGACCTACGGCGAAGCCGTGGAAGAAATGCTCCAATTCGGCGAGAGCGAAGGCGAGCTGATCGGCATGAGCCCCGAGGAGTGGCGGCGATTTGTTGGGCGGGCGTCTCTGTACGCTGCACGCGAAAAGGCCAAGGAATTGGGTGTCGACCCCGGTTGGGATTGCGAGCTGGCGAAGACTCCAGAAGGCTACTACCAAATCCGCGGCGGTATTCAGTATGCGATAGCCAAGTCGTTAGCGGCAGCGCCGTTCGCCGACATCCTTTGGATGGAGACCAAGACCGCTGATTTGGCCGACGCCCGGCAGTTCGCCGAGGCGATCCACGCCGAGTTCCCAGAGCAAATGCTGGCTTACAATCTCTCGCCGTCGTTCAACTGGGATACCACCGGTATGAGTGATGAGGAGATGAAGCGCTTTCCCGAAGAGCTTGGGAAAATGGGCTTCGTCTTCAACTTCATTACCTATGGCGGACATCAGATCGACGGCGTCGCTGCCGAGGAGTTCGCCACCGCGCTGCGGCAGGACGGCATGCTGGCGTTGGCTCGGTTGCAACGCAAGATGCGCCTGGTCGAATCGCCCTACCGCACACCGCAGACCCTGGTCGGCGGCCCGCGTAGCGATGCAGCGCTGGCTGCGTCCTCCGGACGTACGGCGACAACCAAGGCCATGGGCAAAGGTTCGACCCAGCACCAGCATCTTGTGCAGACCGAGGTGCCGAAGAAGCTGCTAGAGGAATGGCTGGCATTGTGGAGTGAGCACTACCAGCTTGGCGAGAAACTCCGCGTGCAACTGCGGCCACGCCGCGCCGGCTCGGATGTGCTCGAACTCGGGATCTACGGCAACGGTGACGAGCAGCTGGCCAACGTCATCGTTGATCCGATCAAGGATCGCCGCGGCCGCAGCATCCTTCAAGTGCGCGACCAGAACACCTTCGCCGAAAAGCTTCGCCAGAAGCGACTGATGACCTTGATCCATTTCTGGCTGGTGCACCGCTTCAAGGCTGACACGGTGATTTACGTCACTCCAACCGAGGATAATCTCTATCAGACTTCCAAGATGAAATCTCACGGCATCTTCAGCGAGGTTTATCAGGAGGTGGGCGAGATCATCGTCGCTGAGGTGAACCACCCGCGGCTTGTTGAGCTGCTTACCCCCGATCGCGTCGCGCTGCGGCGGTTGATCACCAAGGA

Protein Sequence 

>ML1985c_AceA_protein
MSIGRHTGHGRPAM_LN_PGR_TTLLSVRGPG_GGAQSHGHHGHEHRGPHTVYAGSRRNAAIL_RPTVCRDYSPLYSPPGRRTTRHHPHRLHRGTRRRDSFLRSLARAIRGRQERYDVRPLFARASSQP_ADGHRGDLSRRLGNLS_GFHHRRSRS_SRQLPPEPGAR_CRGTGARPAGC_PQSAVPAVTHD_TAACRHSGV_LPPIHHRRRRHGTWR_LARTQPDPPIC_DRRSRIPHRGPAPGYQEVWPSGREGSSAFGRTNQAPQRRPLPARHYAGARHHRRAYRCRGGQLDRQSRR_ARPAVLAGRHQSEDSFLQGLFPGVGAVFLRAGS_GTPWPSPLRVRRWRICCCERVA_SPRDSGPGLRYRQCLAGKRKAIDRRSLRTS_ISVIGRLGEGRRADDLRRSRGRNAPIRRERRRADRHEPRGVAAICWAGVSVRCTRKGQGIGCRPRLGLRAGEDSRRLLPNPRRYSVCDSQVVSGSAVRRHPLDGDQDR_FGRRPAVRRGDPRRVPRANAGLQSLAVVQLGYHRYE__GDEALSRRAWENGLRLQLHYLWRTSDRRRRCRGVRHRAAAGRHAGVGSVATQDAPGRIALPHTADPGRRPA_RCSAGCVLRTYGDNQGHGQRFDPAPASCADRGAEEAARGMAGIVE_ALPAWRETPRATAATPRRLGCARTRDLRQR_RAAGQRHR_SDQGSPRPQHPSSARPEHLRRKASPEATDDLDPFLAGAPLQG_HGDLRHSNRG_SLSDFQDEISRHLQRGLSGGGRDHRR_GEPPAAC_AAYPRSRRAAAVDHQG

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding AceA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

3 show weak predicted evidence for PPIs

View all pooled AlphaFold results for AceA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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