PPE
mL1991
PPE-family protein
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2378501 – 2379907
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1991_PPE_dna
TACCTCCGGAGGTGCACTCGGTTCTGTTAAGTGCTGGACAGGGGGCTGAATCATTGCTTGTTGCCGCTACTCAGTGGCAGGAGCTTAGCAAACAATACACTTACGCAGCTGCCGAGCTGACTCGGCTGCTGACTCATGTTCAGGCCACCAGCTGGCGGGGAACCAGCGCCACACGGTTTGTGGCGGCGCATGGTGCCTATCTGGTCTGGCTCGAACAAACTTCAATCAACAACGCAATCACCGCTAAACAGCATGAAATCGCGGCAATCGCTTACAGCAGCGCGCTAGCCGCCATGCCCACGTTGGCAGAACTTACCGCTAACCGCGCAACTCGTGGTTTCTTGATTGCCACCAACTTCTTCGGCATCAATACCATTCCCATTGCCCTCAACGAAGCCGACTACGTTCGGATGTGGGTGCAAGCCGCCGACACTATGGCGACCTACCAGGCCATCAGCGAGGCGGTGACGGCAACAATACTACCTACCCAAGTAGCGCCACCTATCCTTGCGCCGGGCAGCGCAACCCAAAACGTCCTGCAGTCCGTACCGGATTGGATTGTTCAACTACTGACGGACATCTTGGATTTTATCGCAGATCCATACAAATATTTTCTAAGATTTTTCCAACGATTGGGATTCAGACCCGCTATTGCTGTTGTCCTTGCCATTATTGCTTTGCAATTGTACGACTTTCTTTGGTATCCCTATTATGCCTCGTACGGAATGCTCTTGCTTCCCTTTTTCGCGCCGGCATTGAGCGTCCTGGGTACACTGTCCGTGTTGTGGAACGGACAGCTTTCAGCCGGACTGCCTCCCAATCCCGCAGGATCTCACCCAGACAATAACGCTGGCCCACGCATCCACGTTGGAGTCGCGCCACCTGCCTCGGCTACTTCCAGTGGAAACTCATACACGAGCAACTCCGCACCCAGCACATCCGCATCGGCTACGACTGACAACCCCCTATCTTCACCCAGCATCAGATACGCCATACCCGGCTTGTCGCCACCAGAGGTCAGCTCTGGCCCCAAAGCCGGCACAAAGTCACCTGACACTGCCACCAACACGATCGGGATCACTGCCGCGGCAAGAACAAACTCGCCTTCCGCCCGGGCGCACCGTAAACGAGGAAACAAGACCAGAGGTGGCGCACGCGGTTACCGTTACGAATTCGTTGAAGGAACCGCCACCATGGCCGATACTGTCGACGCCCCCGACCACTCCGAACCCACGTCGCACACAATAAGTAACCACAGCGCCGGCCCCATCGGCTTTGCCGGCACCGTGCCGACAACCGCCAGCACTCCCACCGGAATGGCTGCCAGTACAAGCAGTAGCGTCCCACTGCTCCCCACTACCTGGATAACTGGCACCAGCGAAACGGCAGTACACGAATAGAGAAACT

Protein Sequence 

>ML1991_PPE_protein
YLRRCTRFC_VLDRGLNHCLLPLLSGRSLANNTLTQLPS_LGC_LMFRPPAGGEPAPHGLWRRMVPIWSGSNKLQSTTQSPLNSMKSRQSLTAAR_PPCPRWQNLPLTAQLVVS_LPPTSSASIPFPLPSTKPTTFGCGCKPPTLWRPTRPSARR_RQQYYLPK_RHLSLRRAAQPKTSCSPYRIGLFNY_RTSWILSQIHTNIF_DFSNDWDSDPLLLLSLPLLLCNCTTFFGIPIMPRTECSCFPFSRRH_ASWVHCPCCGTDSFQPDCLPIPQDLTQTITLAHASTLESRHLPRLLPVETHTRATPHPAHPHRLRLTTPYLHPASDTPYPACRHQRSALAPKPAQSHLTLPPTRSGSLPRQEQTRLPPGRTVNEETRPEVAHAVTVTNSLKEPPPWPILSTPPTTPNPRRTQ_VTTAPAPSALPAPCRQPPALPPEWLPVQAVASHCSPLPG_LAPAKRQYTNRET

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PPE with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

7 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

24 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PPE

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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