nrp
mL1996
POSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 2383327 – 2387532
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL1996_nrp_dna
CGCCAAACACACGTCGCGTCGATCGTGTTCCCTTGAGTCGATCTCAGCAGAACATTTACAACGGAATGTTGCAGGACAACGATCCCGCTTTGTATTTTATCGGTAAAAGCTATCGATTCCACCAGCTGGAGCTGTCGGTGTTCCTGGCGGCTCTGGAAGCAACGATCCTCAAAAACCCTGGGCAACTTTGCGTTCTTGAGGCGCCCTCGACAGAGGGTGACTATCCGGATCTCGTGCCGAGGCTGCAGTTCGGCGACATCGTGCGCGTGCGGTCCGACGAACAGCCGCAGACAGACAGTCGTGACTACGACCTTATGCACGCCTGGTCTCCTGACATCCTCGCCAAGCCACTCGTGCGGTACACCGTGCGGACCGACAAGAACGGCTTTGTGGCACGTCTCGATGTCTTCACCCATCACATACTGGTTGATGGCGGCGCGATTAGGATCATTGAGGAAAATTTGGCACATCACCTTGACACCGATAATCGACTCGAGATCCCTTGTATCCGACAAGCTCTGGACAAACTTGCAGAAGCACACCGTCGTGAGGCGACCAAGGTGGAGGAATCGCTACAGCGTCTGGCCAATGTCGTGCAACGTGAGCTAGCCGACGAAGTGCGTAACGGTGGGTATGGTCAAGTCTCAAACGACGCCCCCGGGAACGCTGCCCGGGGAGTGCTTCACGAATCAATGATAATCTGCGGTAAGGCATTTGATAATATTATCGCCTTGTCAGAGACTAAACAGGTGCCACTTAACATATTGGTGGCCACGGCGGCAGTAGCAGTGGACGCTAGCCTTAGGCAGAGCACCGAGGGCCTGCTGGTTCACGCTGTGGACAACCGCTTCGGAGATCCCTATCTGGACGTTGCTACATGCCTGGTCAATTCGGTTGCACACTCGATCCGTTTTCCTCCATTTGCGTCGGTGCAAGATGTCGTCCGAACACTTGACCGGTCCTACGTCAAGGCAATTAGACTCCGCTGGCTTCGCGAGGAATATTACCGACGAATATATTTGGCGCTCAACCAGACATCTCACATTGAGGCTTTGACGCTCAATTTCATACGCGAGCCATGCGCGCCCGGCCTTCGCCCTTTCTTGTCGGAAGTACCGACGGTGACGGATATCGGTCCGGTCGAGGGCATGACCGTGGCTTGTGTTCTGAACGAAGACGAGCGCACACTTGATCTGTCGATCTGGAACAGAGTAGATCTGCCCCAGGGAAAGTCATGTACCCGTGTCGCAAAACGAATCGCTGCAGCGTTGGAATTGATGGCAGCGGCGTGGGATCAGCCGATCGCCATGATTGTCAACGAATGGTTTGGGATCAGTTCAGACGGTGCCCTCTGCCTAGGTAATGAAGTTACCCAGACAACGCGACCACTGGCTCCGGCATGGTTTCTGGACCCTGGGGGAAGCGTTCACCTGACTGTTGACAAACGTCGCTACGTCCATCCATGGATTGCCTGGCTGGTAAGGGGCAGCGTCGTGCCAGGTGACGTGCTGGTGTTCACTGACGACAACACGGACAAGACCATCGACCTCTTGATCGCGTGCCATCTTGCGGGCTGCGGCTACAGTGTCTGTGACACTGTAGCCGAGGTTCCCTTGCGGGCGAAGGCGATTACCGACCACGGTGGTGGTGTCTCTGCCCGCGTGATCGATGTGGCTGCTACCCAGCTCGCAGTGACCCCGGATAACGAGCAAAGCAAGCTCGCTGACAAGCTTATTAAGCAAGCAGCACAAGATATTTCACTAGCAGACAAAACCGCGTACATCATGCCGACATCAGGTTCAACCGGGCAGCCCAAACTCGTCCAAGTTTCACACGGGTCGCTTGCGCTCTTTTGTGACGCGGTGAGAAACGCATATGGGTGGGGAGCACACGACACCATACTCCAGTGCGCGCCATTGACATCGGACATCAGTGTCGAGGAGATCTTTGGTGGAGCGATTTGTGGATCGAAGTTGGTCCGATCCACCGCCATGAAAACTGGTGATCTAGCGGAACTCGCACGAGATATCTTCGTGCAGAGGGCAACAGTCATCGACCTACCGACCGCAGTGTGGCATTTGCTGTGCGACCACAGCGACGCGATTGACGAGATCAACCGTTCTTGCCTTCGACAGATCGTCATTGGGGGTGAAGCCGTTCGTCCCTGCGCTGTCGACAAGTGGATTGATTCCGGTGCTTCACAAGGTATTTCACTTATGTCGACCTATGGACCGACAGAGACTACGGTCGTTGTCACGTATTTGCCGATCGTCTGCGCTCCGATGACCGTCGAGAGTGACGCTCGCCTCAGGCTGGGCTGGCCGATAGTGCCCAACACGGTGTTCATCGCCTTCGGCGAACTCGTTATCGTTGGTGATTTGGTCTCTGTTGGCTATCTCGGGATCGATAGCCGCAACTTCGGCACTGTGACCACCACGGACGGTTCGTGCCGTCGCGCGTTTGCTACTGCCGACTGTGTGATCCTCGATGACGAGGGTTTTCCGGTGTTCTCCGGACGCAAAGACGCCGTCGTCAAAATCTCCGGCAAGCGTGTCGACACCGCCGAGTTAATTCGGCGTATCTCCACGGACCCTAACGTCTCCGATGTTGCTGTCGAAGTTTACAACGGTCGTCTCGGAGTGTGGTTCGAGACGAAGCTGACCCGCGAAGGCGTCGACGATGCTGCGGCAGCGACACGGAGCAGGCTAATTCTTGCGAGCTTGGGAGTGTCCTCGTTTTTCGTGGTAGGCGTGCCGTGTATTCCGCGGAAGCCTAACGGGAAAATTGACCGCGACAACCTGCTGGTGATGCCCCAGCTTGTCGACTCTGTACAAAACTATGCCGGGTCGGGTGAGGGGGCAGCCGGTCTCGCGGAAATCTGGAGTCGGCACCTAGGCAGGGCTATCCTCCCGGACTCATCGCTACTCGATGAGGGGATCGGCTCGGTGGATCTCATCAGGATACTTCCCGACACTCGTAGACATCTGGGTCGGCACCTCTCGCTTCTGGATCTAATCAGCGCCGATAACGCCGCCAACCTGACTGCCGCGCAGACAGCCAATGTATGGATGGACGTCGGCACCGCCGCCGAGATAGAACGTGATCTTGCTTCACTGTGCAGGCAACGAAACGCTACGGAGTTCAGCGTCAAACAGACCCGGAATAGCCACCAAAAACAGGCGATCGTCGTGCTGGGCGCGTCGGGAATTTTGGGCACTGGCTTTGCCCAAGCAGTCCTCGATCTAAGACAGTCAGGAGTGTTGTGTCCCGAGGTGGTCTTGGCTACGAGGGCGAGACTCCCCGAAGGCGATCCATGGACAGCGCTGCAAGGCGTTGATGGGGTTCGGATCGAACGTATCTCTTTTGAGAATGGCCCTGGAGAGCTGGAGGCACTAATACGTGACACTGACGCCGGAACCCTGGTGAACGGTGTCGGCAATACCAACATGCTAGTGCCATACCGTGAACTGCGGCTGGCCAACGTAGAGCTGGTTTCCGCGATAGTCGATATATGCGCGAGTTATAGTACCAGGTTGGTACATTTGTCGTCATTCGTCGTCAATGCGGATGTCACTGTGCCTCAGGTCACCGATCCCCGTGAAACGCCTTATCCGTATGCGGCATCCAAGTCACTCGCGGAGCTAGTCGTTGCCGGATCACCATCTGCGCTCGATTTCACCATCGTGCGCCTGCCCCGGGTACTTGGCGAAGACTATCAATTACGCAATTCCTCTGACATTCTACTCTCGATTGTTGATGCCTGTATTGCGTTGCGCGCCTACCCTTCCGCAACAGTGACGGAAGAAGTCACTACCGGCCGAGCCGCGGCGAAGGCGATCTTGGGCGTGGTGTCGGCGTTAGCTAGATCGGGTCAGCTGGGGAGCGGAATTTCCGTGGTACGTGGCGAGGCGGTGGCATACGCGGATTTTCTCAGTGAGTTCGCTAGCGATGAACTCAATATGGCGGAGTGGAAGTATCGACTGGATCAAAGCGACTGGGCGAAGAGAAATCCACGAAGGTGGTCGGTGATCGATGCGTGGTTCACCTTGGGTATGATGTTCGAGATGCGATCCTACGCAGAATATCCGACCATGGCCCTCGGCGTCGAGTCCGTCGCCGAGCTTGCCGCGCCACCAGAGTCGATTCGAGCCCTACTAGCGCACGGATGTTCACAGCCACTGAAATATACTGGCAGATAGCAACTGC

Protein Sequence 

>ML1996_Nrp_protein
RQTHVASIVFP_VDLSRTFTTECCRTTIPLCILSVKAIDSTSWSCRCSWRLWKQRSSKTLGNFAFLRRPRQRVTIRISCRGCSSATSCACGPTNSRRQTVVTTTLCTPGLLTSSPSHSCGTPCGPTRTALWHVSMSSPITYWLMAARLGSLRKIWHITLTPIIDSRSLVSDKLWTNLQKHTVVRRPRWRNRYSVWPMSCNVS_PTKCVTVGMVKSQTTPPGTLPGECFTNQ__SAVRHLIILSPCQRLNRCHLTYWWPRRQ_QWTLALGRAPRACWFTLWTTASEIPIWTLLHAWSIRLHTRSVFLHLRRCKMSSEHLTGPTSRQLDSAGFARNITDEYIWRSTRHLTLRL_RSISYASHARPAFALSCRKYRR_RISVRSRA_PWLVF_TKTSAHLICRSGTE_ICPRESHVPVSQNESLQRWN_WQRRGISRSP_LSTNGLGSVQTVPSA_VMKLPRQRDHWLRHGFWTLGEAFT_LLTNVATSIHGLPGW_GAASCQVTCWCSLTTTRTRPSTS_SRAILRAAATVSVTL_PRFPCGRRRLPTTVVVSLPA_SMWLLPSSQ_PRITSKASSLTSLLSKQHKIFH_QTKPRTSCRHQVQPGSPNSSKFHTGRLRSFVTR_ETHMGGEHTTPYSSARH_HRTSVSRRSLVERFVDRSWSDPPP_KLVI_RNSHEISSCRGQQSSTYRPQCGICCATTATRLTRSTVLAFDRSSLGVKPFVPALSTSGLIPVLHKVFHLCRPMDRQRLRSLSRICRSSALR_PSRVTLASGWAGR_CPTRCSSPSANSLSLVIWSLLAISGSIAATSAL_PPRTVRAVARLLLPTV_SSMTRVFRCSPDAKTPSSKSPASVSTPPS_FGVSPRTLTSPMLLSKFTTVVSECGSRRS_PAKASTMLRQRHGAG_FLRAWECPRFSW_ACRVFRGSLTGKLTATTCW_CPSLSTLYKTMPGRVRGQPVSRKSGVGT_AGLSSRTHRYSMRGSARWISSGYFPTLVDIWVGTSRFWI_SAPITPPT_LPRRQPMYGWTSAPPPR_NVILLHCAGNETLRSSASNRPGIATKNRRSSCWARREFWALALPKQSSI_DSQECCVPRWSWLRGRDSPKAIHGQRCKALMGFGSNVSLLRMALESWRH_YVTLTPEPW_TVSAIPTC_CHTVNCGWPT_SWFPR_SIYARVIVPGWYICRHSSSMRMSLCLRSPIPVKRLIRMRHPSHSRS_SLPDHHLRSISPSCACPGYLAKTINYAIPLTFYSRLLMPVLRCAPTLPQQ_RKKSLPAEPRRRRSWAWCRR_LDRVSWGAEFPWYVARRWHTRIFSVSSLAMNSIWRSGSIDWIKATGRREIHEGGR_SMRGSPWV_CSRCDPTQNIRPWPSASSPSPSLPRHQSRFEPY_RTDVHSH_NILADSNC

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding Nrp with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

4 show intermediate predicted evidence for PPIs

44 show weak predicted evidence for PPIs

View all pooled AlphaFold results for Nrp

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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